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Title:
Metabolic engineering for the microbial production of carotenoids and related products with a focus on the rare C50 carotenoids | Applied Microbiology and Biotechnology
Description:
Carotenoids, a subfamily of terpenoids, are yellow- to red-colored pigments synthesized by plants, fungi, algae, and bacteria. They are ubiquitous in nature and take over crucial roles in many biological processes as for example photosynthesis, vision, and the quenching of free radicals and singlet oxygen. Due to their color and their potential beneficial effects on human health, carotenoids receive increasing attention. Carotenoids can be classified due to the length of their carbon backbone. Most carotenoids have a C40 backbone, but also C30 and C50 carotenoids are known. All carotenoids are derived from isopentenyl pyrophosphate (IPP) as a common precursor. Pathways leading to IPP as well as metabolic engineering of IPP synthesis and C40 carotenoid production have been reviewed expertly elsewhere. Since C50 carotenoids are synthesized from the C40 carotenoid lycopene, we will summarize common strategies for optimizing lycopene production and we will focus our review on the characteristics, biosynthesis, glycosylation, and overproduction of C50 carotenoids.
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pubmed, google, scholar, cas, carotenoids, central, biotechnol, production, carotenoid, microbiol, appl, biosynthesis, engineering, dois, metabolic, plant, pathway, astaxanthin, environ, coli, corynebacterium, doiaem, article, wendisch, escherichia, glutamicum, microbial, doi, chem, sci, products, pathways, biol, van, biochem, genes, sandmann, gene, bacteria, synthesis, saccharomyces, cerevisiae, bacteriol, ccarotenoids, kim, lee, isoprenoid, functional, bacillus, subtilis,
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headline:Metabolic engineering for the microbial production of carotenoids and related products with a focus on the rare C50 carotenoids
description:Carotenoids, a subfamily of terpenoids, are yellow- to red-colored pigments synthesized by plants, fungi, algae, and bacteria. They are ubiquitous in nature and take over crucial roles in many biological processes as for example photosynthesis, vision, and the quenching of free radicals and singlet oxygen. Due to their color and their potential beneficial effects on human health, carotenoids receive increasing attention. Carotenoids can be classified due to the length of their carbon backbone. Most carotenoids have a C40 backbone, but also C30 and C50 carotenoids are known. All carotenoids are derived from isopentenyl pyrophosphate (IPP) as a common precursor. Pathways leading to IPP as well as metabolic engineering of IPP synthesis and C40 carotenoid production have been reviewed expertly elsewhere. Since C50 carotenoids are synthesized from the C40 carotenoid lycopene, we will summarize common strategies for optimizing lycopene production and we will focus our review on the characteristics, biosynthesis, glycosylation, and overproduction of C50 carotenoids.
datePublished:2014-04-01T00:00:00Z
dateModified:2014-04-01T00:00:00Z
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keywords:
Metabolic engineering of carotenoids
C50 carotenoids
Lycopene elongase
C50 carotenoid cyclase
C50 carotenoid glucosyltransferase
Microbiology
Microbial Genetics and Genomics
Biotechnology
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description:Carotenoids, a subfamily of terpenoids, are yellow- to red-colored pigments synthesized by plants, fungi, algae, and bacteria. They are ubiquitous in nature and take over crucial roles in many biological processes as for example photosynthesis, vision, and the quenching of free radicals and singlet oxygen. Due to their color and their potential beneficial effects on human health, carotenoids receive increasing attention. Carotenoids can be classified due to the length of their carbon backbone. Most carotenoids have a C40 backbone, but also C30 and C50 carotenoids are known. All carotenoids are derived from isopentenyl pyrophosphate (IPP) as a common precursor. Pathways leading to IPP as well as metabolic engineering of IPP synthesis and C40 carotenoid production have been reviewed expertly elsewhere. Since C50 carotenoids are synthesized from the C40 carotenoid lycopene, we will summarize common strategies for optimizing lycopene production and we will focus our review on the characteristics, biosynthesis, glycosylation, and overproduction of C50 carotenoids.
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Metabolic engineering of carotenoids
C50 carotenoids
Lycopene elongase
C50 carotenoid cyclase
C50 carotenoid glucosyltransferase
Microbiology
Microbial Genetics and Genomics
Biotechnology
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