We are analyzing https://link.springer.com/article/10.1007/s00253-010-2976-6.

Title:
Biotechnological production of astaxanthin with Phaffia rhodozyma/Xanthophyllomyces dendrorhous | Applied Microbiology and Biotechnology
Description:
The oxygenated β-carotene derivative astaxanthin exhibits outstanding colouring, antioxidative and health-promoting properties and is mainly found in the marine environment. To satisfy the growing demand for this ketocarotenoid in the feed, food and cosmetics industries, there are strong efforts to develop economically viable bioprocesses alternative to the current chemical synthesis. However, up to now, natural astaxanthin from Haematococcus pluvialis, Phaffia rhodozyma or Paracoccus carotinifaciens has not been cost competitive with chemically synthesized astaxanthin, thus only serving niche applications. This review illuminates recent advances made in elucidating astaxanthin biosynthesis in P. rhodozyma. It intensely focuses on strategies to increase astaxanthin titers in the heterobasidiomycetous yeast by genetic engineering of the astaxanthin pathway, random mutagenesis and optimization of fermentation processes. This review emphasizes the potential of P. rhodozyma for the biotechnological production of astaxanthin in comparison to other natural sources such as the microalga H. pluvialis, other fungi and transgenic plants and to chemical synthesis.
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Keywords {🔍}

google, scholar, article, cas, astaxanthin, phaffia, rhodozyma, production, biotechnol, dendrorhous, microbiol, xanthophyllomyces, yeast, appl, carotenoid, carotenoids, biosynthesis, gene, van, patent, engineering, lett, fedbatch, food, johnson, growth, bioeng, sandmann, fermentation, mutant, metabolic, biochem, environ, culture, optimization, kim, international, effect, misawa, haematococcus, pluvialis, biol, medium, cultures, wang, verdoes, ooyen, content, research, synthesis,

Topics {✒️}

org/environment/israel-grows-red-algae month download article/chapter orange gram-negative coccus β-carotene producing mutants low-dose gamma irradiation gas chromatography–mass spectrometry affiliations karl-winnacker-institut cytochrome-p450 hydroxylase involved carotenoid-hyperproducing mutant 2a2n red-pigmented fermenting yeast bifunctional hydroxylase–ketolase protein ß-carotene hydroxylase gene 4′-didehydro-beta-psi-caroten-4 article applied microbiology beta-carotene 3-hydroxylase/4-ketolase carbon-source assimilation pattern cyanobacterium synechocystis sp phytoene synthase gene full article pdf van den berg astaxanthin synthase gene zeaxanthin-producing bacterium privacy choices/manage cookies astaxanthin fermentation bioprocess phaffia rhodozyma/xanthophyllomyces dendrorhous carotenoid hyperproducing mutants european economic area engineering ketocarotenoid biosynthesis carotinoide der süßwasseralgen cytochrome p450 reductase elucidating astaxanthin biosynthesis accelerated astaxanthin biosynthesis paracoccus carotinifaciens sp chao jin alfalfa residual juice saccharomyces cerevisiae jens schrader carotenoid biosynthetic gene astaxanthin biosynthesis pathway van ooyen aj phaffia rhodozyma mutant 1007/s00253-010-2814 astaxanthin-producing strains paracoccus zeaxanthinifaciens sp paracoccus marcusii sp chemically defined medium van dyk ms van gorcom rfm van ooyen ajj du preez jc

Questions {❓}

Martín JF, Gudina E, Barredo JL (2008) Conversion of beta-carotene into astaxanthin: two separate enzymes or a bifunctional hydroxylase–ketolase protein?

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         description:The oxygenated β-carotene derivative astaxanthin exhibits outstanding colouring, antioxidative and health-promoting properties and is mainly found in the marine environment. To satisfy the growing demand for this ketocarotenoid in the feed, food and cosmetics industries, there are strong efforts to develop economically viable bioprocesses alternative to the current chemical synthesis. However, up to now, natural astaxanthin from Haematococcus pluvialis, Phaffia rhodozyma or Paracoccus carotinifaciens has not been cost competitive with chemically synthesized astaxanthin, thus only serving niche applications. This review illuminates recent advances made in elucidating astaxanthin biosynthesis in P. rhodozyma. It intensely focuses on strategies to increase astaxanthin titers in the heterobasidiomycetous yeast by genetic engineering of the astaxanthin pathway, random mutagenesis and optimization of fermentation processes. This review emphasizes the potential of P. rhodozyma for the biotechnological production of astaxanthin in comparison to other natural sources such as the microalga H. pluvialis, other fungi and transgenic plants and to chemical synthesis.
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      description:The oxygenated β-carotene derivative astaxanthin exhibits outstanding colouring, antioxidative and health-promoting properties and is mainly found in the marine environment. To satisfy the growing demand for this ketocarotenoid in the feed, food and cosmetics industries, there are strong efforts to develop economically viable bioprocesses alternative to the current chemical synthesis. However, up to now, natural astaxanthin from Haematococcus pluvialis, Phaffia rhodozyma or Paracoccus carotinifaciens has not been cost competitive with chemically synthesized astaxanthin, thus only serving niche applications. This review illuminates recent advances made in elucidating astaxanthin biosynthesis in P. rhodozyma. It intensely focuses on strategies to increase astaxanthin titers in the heterobasidiomycetous yeast by genetic engineering of the astaxanthin pathway, random mutagenesis and optimization of fermentation processes. This review emphasizes the potential of P. rhodozyma for the biotechnological production of astaxanthin in comparison to other natural sources such as the microalga H. pluvialis, other fungi and transgenic plants and to chemical synthesis.
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