We are analyzing https://link.springer.com/article/10.1007/s002510050594.

Title:
Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism | Immunogenetics
Description:
Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological relevance, we analyze the frequency at which these supertype alleles are expressed in various ethnicities and discuss the relevance of those observations to vaccine development. Next, the existence of five new supertypes (A1, A24, B27, B58, and B62) is reported. As a result, it is possible to account for the predominance of all known HLA class I with only nine main functional binding specificities. The practical implications of this finding, as well as its relevance to understanding the functional implication of MHC polymorphism in humans, are discussed.
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Keywords {🔍}

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Topics {✒️}

hla supertype-specific epitopes hla-b57 micropolymorphism defines month download article/chapter major hla class article immunogenetics aims privacy choices/manage cookies full article pdf mhc polymorphism related subjects hla class main structural features european economic area polymorphism review published scope submit manuscript biological data demonstrating conditions privacy policy check access instant access b44- supertype alleles accepting optional cookies usa e-mail hla supertypes journal finder publish article log sidney rights article cite november 1999 volume 50 article sette personal data privacy policy supertype alleles books a optional cookies supertypes account manage preferences functional implication subscription content similar content data protection essential cookies cookies skip institution subscribe journal publish hla usage analysis social media varying standards vast preponderance epitope approach vaccines

Schema {🗺️}

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         headline:Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism
         description: Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological relevance, we analyze the frequency at which these supertype alleles are expressed in various ethnicities and discuss the relevance of those observations to vaccine development. Next, the existence of five new supertypes (A1, A24, B27, B58, and B62) is reported. As a result, it is possible to account for the predominance of all known HLA class I with only nine main functional binding specificities. The practical implications of this finding, as well as its relevance to understanding the functional implication of MHC polymorphism in humans, are discussed.
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      headline:Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism
      description: Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological relevance, we analyze the frequency at which these supertype alleles are expressed in various ethnicities and discuss the relevance of those observations to vaccine development. Next, the existence of five new supertypes (A1, A24, B27, B58, and B62) is reported. As a result, it is possible to account for the predominance of all known HLA class I with only nine main functional binding specificities. The practical implications of this finding, as well as its relevance to understanding the functional implication of MHC polymorphism in humans, are discussed.
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         Supertypes
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         MHC
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         Human Genetics
         Gene Function
         Cell Biology
         Allergology
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