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We are analyzing https://link.springer.com/article/10.1007/s002510000217.

Title:
An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries | Immunogenetics
Description:
Specificities of three mouse major histocompatibility complex (MHC) class I molecules, Kb, Db, and Ld, were analyzed by positional scanning using combinatorial peptide libraries. The result of the analysis was used to create a scoring program to predict MHC-binding peptides in proteins. The capacity of the scoring was then challenged with a number of peptides by comparing the prediction with the experimental binding. The score and the experimental binding exhibited a linear correlation but with substantial deviations of data points. Statistically, for approximately 80% of randomly chosen peptides, MHC-binding capacity could be predicted within one log concentration of peptides for a half-maximal binding. Known cytotoxic T-lymphocyte epitope peptides could be predicted, with a few exceptions. In addition, frequent findings of MHC-binding peptides with incomplete or no anchor amino acid(s) suggested a substantial bias introduced by natural antigen processing in peptide selection by MHC class I molecules.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
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What CMS is link.springer.com built with?

Custom-built

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Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

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Keywords {🔍}

article, mhc, class, peptides, peptide, access, kyoto, university, privacy, cookies, content, department, japan, data, information, log, publish, search, prediction, processing, journal, research, immunogenetics, positional, scanning, libraries, udaka, wiesmüller, kienle, mhcbinding, binding, open, predictions, discover, sakyo, germany, tokyo, springer, function, optional, analysis, personal, parties, policy, find, track, automated, ibinding, based, cite,

Topics {✒️}

natural antigen processing predict mhc-binding peptides month download article/chapter targeted mhc class mhc-binding peptides related subjects mhc class mhc-binding capacity full article pdf combinatorial peptide libraries article immunogenetics aims privacy choices/manage cookies half-maximal binding karl-heinz wiesmüller randomly chosen peptides experimental binding exhibited european economic area anchor amino acid article udaka conditions privacy policy substantial bias introduced peptide libraries accepting optional cookies günther jung ko okumura check access instant access function journal finder publish article log peptide selection stefan kienle hirokazu tamamura article cite processing experimental binding mhc class information privacy policy personal data screening books a affiliations department optional cookies manage preferences hideo yamagishi peter walden subscription content similar content

Schema {🗺️}

WebPage:
      mainEntity:
         headline:An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries
         description: Specificities of three mouse major histocompatibility complex (MHC) class I molecules, Kb, Db, and Ld, were analyzed by positional scanning using combinatorial peptide libraries. The result of the analysis was used to create a scoring program to predict MHC-binding peptides in proteins. The capacity of the scoring was then challenged with a number of peptides by comparing the prediction with the experimental binding. The score and the experimental binding exhibited a linear correlation but with substantial deviations of data points. Statistically, for approximately 80% of randomly chosen peptides, MHC-binding capacity could be predicted within one log concentration of peptides for a half-maximal binding. Known cytotoxic T-lymphocyte epitope peptides could be predicted, with a few exceptions. In addition, frequent findings of MHC-binding peptides with incomplete or no anchor amino acid(s) suggested a substantial bias introduced by natural antigen processing in peptide selection by MHC class I molecules.
         datePublished:
         dateModified:
         pageStart:816
         pageEnd:828
         sameAs:https://doi.org/10.1007/s002510000217
         keywords:
            MHC class I Peptide Library Prediction
            Immunology
            Human Genetics
            Gene Function
            Cell Biology
            Allergology
         image:
         isPartOf:
            name:Immunogenetics
            issn:
               1432-1211
               0093-7711
            volumeNumber:51
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
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            type:Organization
         author:
               name:Keiko Udaka
               affiliation:
                     name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
                     address:
                        name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
                        type:PostalAddress
                     type:Organization
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               name:Karl-Heinz Wiesmüller
               affiliation:
                     name:Evotec BioSystems GmbH, 22529 Hamburg, Germany
                     address:
                        name:Evotec BioSystems GmbH, 22529 Hamburg, Germany,
                        type:PostalAddress
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               name:Stefan Kienle
               affiliation:
                     name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
                     address:
                        name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
                        type:PostalAddress
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               name:Günther Jung
               affiliation:
                     name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
                     address:
                        name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hirokazu Tamamura
               affiliation:
                     name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
                     address:
                        name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hideo Yamagishi
               affiliation:
                     name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
                     address:
                        name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ko Okumura
               affiliation:
                     name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan
                     address:
                        name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan,
                        type:PostalAddress
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                     address:
                        name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany,
                        type:PostalAddress
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               name:Taku Suto
               affiliation:
                     name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan
                     address:
                        name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Toshisuke Kawasaki
               affiliation:
                     name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
                     address:
                        name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
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ScholarlyArticle:
      headline:An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries
      description: Specificities of three mouse major histocompatibility complex (MHC) class I molecules, Kb, Db, and Ld, were analyzed by positional scanning using combinatorial peptide libraries. The result of the analysis was used to create a scoring program to predict MHC-binding peptides in proteins. The capacity of the scoring was then challenged with a number of peptides by comparing the prediction with the experimental binding. The score and the experimental binding exhibited a linear correlation but with substantial deviations of data points. Statistically, for approximately 80% of randomly chosen peptides, MHC-binding capacity could be predicted within one log concentration of peptides for a half-maximal binding. Known cytotoxic T-lymphocyte epitope peptides could be predicted, with a few exceptions. In addition, frequent findings of MHC-binding peptides with incomplete or no anchor amino acid(s) suggested a substantial bias introduced by natural antigen processing in peptide selection by MHC class I molecules.
      datePublished:
      dateModified:
      pageStart:816
      pageEnd:828
      sameAs:https://doi.org/10.1007/s002510000217
      keywords:
         MHC class I Peptide Library Prediction
         Immunology
         Human Genetics
         Gene Function
         Cell Biology
         Allergology
      image:
      isPartOf:
         name:Immunogenetics
         issn:
            1432-1211
            0093-7711
         volumeNumber:51
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
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            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Keiko Udaka
            affiliation:
                  name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
                  address:
                     name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Karl-Heinz Wiesmüller
            affiliation:
                  name:Evotec BioSystems GmbH, 22529 Hamburg, Germany
                  address:
                     name:Evotec BioSystems GmbH, 22529 Hamburg, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan Kienle
            affiliation:
                  name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
                  address:
                     name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Günther Jung
            affiliation:
                  name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
                  address:
                     name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hirokazu Tamamura
            affiliation:
                  name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
                  address:
                     name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hideo Yamagishi
            affiliation:
                  name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
                  address:
                     name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ko Okumura
            affiliation:
                  name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan
                  address:
                     name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan,
                     type:PostalAddress
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            type:Person
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            affiliation:
                  name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany
                  address:
                     name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Taku Suto
            affiliation:
                  name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan
                  address:
                     name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Toshisuke Kawasaki
            affiliation:
                  name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
                  address:
                     name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
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      name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
      address:
         name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
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      name:Evotec BioSystems GmbH, 22529 Hamburg, Germany
      address:
         name:Evotec BioSystems GmbH, 22529 Hamburg, Germany,
         type:PostalAddress
      name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
      address:
         name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
         type:PostalAddress
      name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
      address:
         name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
         type:PostalAddress
      name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
      address:
         name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
         type:PostalAddress
      name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
      address:
         name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
         type:PostalAddress
      name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan
      address:
         name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan,
         type:PostalAddress
      name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany
      address:
         name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany,
         type:PostalAddress
      name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan
      address:
         name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan,
         type:PostalAddress
      name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
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Person:
      name:Keiko Udaka
      affiliation:
            name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
            address:
               name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
               type:PostalAddress
            type:Organization
      name:Karl-Heinz Wiesmüller
      affiliation:
            name:Evotec BioSystems GmbH, 22529 Hamburg, Germany
            address:
               name:Evotec BioSystems GmbH, 22529 Hamburg, Germany,
               type:PostalAddress
            type:Organization
      name:Stefan Kienle
      affiliation:
            name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
            address:
               name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
               type:PostalAddress
            type:Organization
      name:Günther Jung
      affiliation:
            name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany
            address:
               name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
               type:PostalAddress
            type:Organization
      name:Hirokazu Tamamura
      affiliation:
            name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
            address:
               name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
               type:PostalAddress
            type:Organization
      name:Hideo Yamagishi
      affiliation:
            name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
            address:
               name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
               type:PostalAddress
            type:Organization
      name:Ko Okumura
      affiliation:
            name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan
            address:
               name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan,
               type:PostalAddress
            type:Organization
      name:Peter Walden
      affiliation:
            name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany
            address:
               name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany,
               type:PostalAddress
            type:Organization
      name:Taku Suto
      affiliation:
            name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan
            address:
               name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan,
               type:PostalAddress
            type:Organization
      name:Toshisuke Kawasaki
      affiliation:
            name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan
            address:
               name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
      name:Evotec BioSystems GmbH, 22529 Hamburg, Germany,
      name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
      name:Department of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany,
      name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
      name:Department of Biophysics, Kyoto University, Sakyo, Kyoto, 606-8502, Japan,
      name:Department of Immunology, School of Medicine, Juntendo University, Hongo, Bunkyo, Tokyo, 113, Japan,
      name:Dermatologische Klinik und Poliklinik, Charité, Humboldt Universität zu Berlin, 10117 Berlin, Germany,
      name:Department of Naval Architecture and Oceanic Engineering, Institute of Industrial Sciences, University of Tokyo, Minato, Tokyo, Japan,
      name:Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto, 606-8501, Japan,
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