We are analyzing https://link.springer.com/article/10.1007/s00251-004-0675-0.

Title:
Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken | Immunogenetics
Description:
Antimicrobial peptides (AMPs) are essential components of innate immunity in a range of species from Drosophila to humans and are generally thought to act by disrupting the membrane integrity of microbes. In order to discover novel AMPs in the chicken, we have implemented a bioinformatic approach that involves the clustering of more than 420,000 chicken expressed sequence tags (ESTs). Similarity searching of proteins—predicted to be encoded by these EST clusters—for homology to known AMPs has resulted in the in silico identification of full-length sequences for seven novel gallinacins (Gal-4 to Gal-10), a novel cathelicidin and a novel liver-expressed antimicrobial peptide 2 (LEAP-2) in the chicken. Differential gene expression of these novel genes has been demonstrated across a panel of chicken tissues. An evolutionary analysis of the gallinacin family has detected sites—primarily in the mature AMP—that are under positive selection in these molecules. The functional implications of these results are discussed.
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Keywords {🔍}

google, scholar, pubmed, cas, article, antimicrobial, peptide, chicken, peptides, human, genes, expressed, activity, dublin, protein, ireland, research, lynn, biol, infect, yang, privacy, cookies, content, search, higgs, innate, cathelicidin, access, sci, immun, mol, department, analysis, publish, david, rowan, lloyd, ofarrelly, discover, identification, gene, expression, models, antibiotic, usa, res, gallo, lehrer, genetics,

Topics {✒️}

month download article/chapter mammalian cathelicidin-derived peptides cysteine-rich antimicrobial peptides inducible epithelial β-defensin accurate multiple-sequence alignment peptide antibiotic ll-37/hcap-18 protein-coding dna sequences cathelicidin antimicrobial peptides antimicrobial peptide genes amino acid sites article immunogenetics aims protegrin-related peptides innate defense system full article pdf mammalian β-defensins anti-microbial activity human β-defensin-1 antimicrobial resistance genes human cap18 peptides privacy choices/manage cookies antimicrobial protein gloverin α-defensin precursors differential gene expression broad antimicrobial activity invasive bacterial infection detected sites—primarily cathelin/pro-bactenecin rapid sequence divergence hiv-1 envelope gene blood peptide expressed potent antibiotic activity related subjects codon-substitution models antimicrobial peptides european economic area joanna tierney full-length sequences codon-based model frohm-nilsson low number wins nonsynonymous rate variation bioinformatic discovery authors david lynn conditions privacy policy heterogeneous selection pressure article lynn human squamous epithelia human colon epithelium conejo-garcia jr software system

Schema {🗺️}

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         headline:Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken
         description:Antimicrobial peptides (AMPs) are essential components of innate immunity in a range of species from Drosophila to humans and are generally thought to act by disrupting the membrane integrity of microbes. In order to discover novel AMPs in the chicken, we have implemented a bioinformatic approach that involves the clustering of more than 420,000 chicken expressed sequence tags (ESTs). Similarity searching of proteins—predicted to be encoded by these EST clusters—for homology to known AMPs has resulted in the in silico identification of full-length sequences for seven novel gallinacins (Gal-4 to Gal-10), a novel cathelicidin and a novel liver-expressed antimicrobial peptide 2 (LEAP-2) in the chicken. Differential gene expression of these novel genes has been demonstrated across a panel of chicken tissues. An evolutionary analysis of the gallinacin family has detected sites—primarily in the mature AMP—that are under positive selection in these molecules. The functional implications of these results are discussed.
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      name:Education and Research Centre, St. Vincent’s University Hospital, Dublin, Ireland
      name:Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland
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      name:Department of Genetics, Trinity College Dublin, Dublin, Ireland
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