We are analyzing https://link.springer.com/article/10.1007/s002400000148.

Title:
Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer | Urolithiasis
Description:
Cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase-2 (NOS-2) each have an important role in angiogenesis. The expression of these genes was investigated in human prostate cancer by immunohistochemistry, the expression of COX-1 and COX-2 being confirmed by mRNA analysis. Prostate cancer specimens from 12 patients were compared to control prostates from 13 patients operated on for bladder carcinoma. The intensity of COX-2 and NOS-2 immunostaining was significantly stronger in prostate cancer cells than in the non-malignant glandular epithelium of the control prostates. COX-2 and NOS-2 were clearly also expressed in the lesions of prostatic intraepithelial neoplasia (PIN) in control prostates. COX-2 was detected in the muscle fibres of the hyperplastic stroma of some control prostates. No significant difference was detected in COX-1 expression between control and cancer prostates. These results indicate that the expression of COX-2 and NOS-2 is elevated in prostatic adenocarcinoma and in PIN.
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Keywords {🔍}

article, cox, cancer, prostate, expression, cyclooxygenase, research, turku, privacy, cookies, content, control, prostates, prostatic, access, information, publish, search, urological, nitric, oxide, synthase, nos, university, finland, data, log, journal, human, uotila, valve, martikainen, discover, department, springer, optional, analysis, personal, parties, policy, find, track, increased, cite, pekka, eeva, paula, marja, nevalainen, martti,

Topics {✒️}

prostatic intraepithelial neoplasia nitric oxide synthase-2 human prostate cancer month download article/chapter prostate cancer specimens prostate cancer cells related subjects urological research 29 malignant glandular epithelium privacy choices/manage cookies full article pdf prostatic adenocarcinoma check access instant access european economic area clinic-pathological significances conditions privacy policy cancer prostates accepting optional cookies increased expression article uotila main content log finland e-mail journal finder publish marja nevalainen angiogenesis article log tampere university hospital article cite cyclooxygenase-2 fi tel privacy policy personal data books a paula martikainen information optional cookies manage preferences lesions data protection essential cookies cookies skip subscription content similar content eeva valve institution subscribe journal publish cox-1 expression cox-2 expression usage analysis

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         description: Cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase-2 (NOS-2) each have an important role in angiogenesis. The expression of these genes was investigated in human prostate cancer by immunohistochemistry, the expression of COX-1 and COX-2 being confirmed by mRNA analysis. Prostate cancer specimens from 12 patients were compared to control prostates from 13 patients operated on for bladder carcinoma. The intensity of COX-2 and NOS-2 immunostaining was significantly stronger in prostate cancer cells than in the non-malignant glandular epithelium of the control prostates. COX-2 and NOS-2 were clearly also expressed in the lesions of prostatic intraepithelial neoplasia (PIN) in control prostates. COX-2 was detected in the muscle fibres of the hyperplastic stroma of some control prostates. No significant difference was detected in COX-1 expression between control and cancer prostates. These results indicate that the expression of COX-2 and NOS-2 is elevated in prostatic adenocarcinoma and in PIN.
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            Nephrology
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      headline:Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer
      description: Cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase-2 (NOS-2) each have an important role in angiogenesis. The expression of these genes was investigated in human prostate cancer by immunohistochemistry, the expression of COX-1 and COX-2 being confirmed by mRNA analysis. Prostate cancer specimens from 12 patients were compared to control prostates from 13 patients operated on for bladder carcinoma. The intensity of COX-2 and NOS-2 immunostaining was significantly stronger in prostate cancer cells than in the non-malignant glandular epithelium of the control prostates. COX-2 and NOS-2 were clearly also expressed in the lesions of prostatic intraepithelial neoplasia (PIN) in control prostates. COX-2 was detected in the muscle fibres of the hyperplastic stroma of some control prostates. No significant difference was detected in COX-1 expression between control and cancer prostates. These results indicate that the expression of COX-2 and NOS-2 is elevated in prostatic adenocarcinoma and in PIN.
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         Nitric oxide synthase-2
         Urology
         Nephrology
         Medical Biochemistry
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