We are analyzing https://link.springer.com/article/10.1007/s00240-020-01202-w.

Title:
Calcium oxalate crystal deposition in the kidney: identification, causes and consequences | Urolithiasis
Description:
Calcium oxalate (CaOx) crystal deposition within the tubules is often a perplexing finding on renal biopsy of both native and transplanted kidneys. Understanding the underlying causes may help diagnosis and future management. The most frequent cause of CaOx crystal deposition within the kidney is hyperoxaluria. When this is seen in native kidney biopsy, primary hyperoxaluria must be considered and investigated further with biochemical and genetic tests. Secondary hyperoxaluria, for example due to enteric hyperoxaluria following bariatric surgery, ingested ethylene glycol or vitamin C overdose may also cause CaOx deposition in native kidneys. CaOx deposition is a frequent finding in renal transplant biopsy, often as a consequence of acute tubular necrosis and is associated with poorer long-term graft outcomes. CaOx crystal deposition in the renal transplant may also be secondary to any of the causes associated with this phenotype in the native kidney. The pathophysiology underlying CaOx deposition is complex but this histological phenotype may indicate serious underlying pathology and should always warrant further investigation.
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Keywords {🔍}

oxalate, article, google, scholar, pubmed, renal, cas, caox, hyperoxaluria, kidney, deposition, crystal, calcium, crystals, nephropathy, primary, acute, graft, biopsy, transplant, type, failure, function, transplanted, secondary, tubular, central, nephrol, kidneys, oxalosis, patients, chronic, httpsdoiorgs, nephrolithiasis, case, int, native, demonstrated, clin, httpsdoiorg, sayer, damage, urinary, stone, research, urolithiasis, disease, cells, transplantation, human,

Topics {✒️}

orlistat-induced oxalate nephropathy article download pdf acute cell‐mediated rejection glycolate reductase/hydroxypyruvate reductase enzyme 4-hydroxy-2-oxoglutarate aldolase induced oxalate nephropathy long-term graft survival gut-inhabiting bacterium oxalobacterformigenes potentially life-changing effects genetic hypercalciuric stone-forming initial post-operative period human 4-hydroxy-2-oxoglutarate aldolase long-term graft failure acute graft dysfunction evan ap shape-dependent cellular toxicity chronic tubular injury acute kidney injury kok dj subsequent epithelial damage combined liver-kidney transplantation chronic kidney disease calcium oxalate deposition privacy choices/manage cookies calcium oxalate urolithiasis acute tubular necrosis �acute tubular necrosis” renal crystal deposition severe disease phenotypes abd el kader fixed particle disease calcium oxalate microdeposition renal damage resulting renal tubular fluid long-term outcomes show bright birefringence calcium oxalate crystals subsequent oxalate nephropathy freel rw crystal deposition differ institutional research committee including dual kidney hydroxyproline concentrations increased intérêt clinique de calcium oxalate crystalluria renal epithelial cells acute oxalate nephropathy stone formers originates nondiabetic stone formers kidney graft biopsies

Questions {❓}

Fioretto P, Barzon I, Mauer M (2014) Is diabetic nephropathy reversible?
Muji A, Moll S, Saudan P (2015) Oxalate nephropathy: a new entity of acute kidney injury in diabetic patients?
Winkens RA, Wielders JP, Degenaar CP, van Hoof JP (1988) Calcium oxalate crystalluria, a curiosity or a diagnostical aid?

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      headline:Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
      description:Calcium oxalate (CaOx) crystal deposition within the tubules is often a perplexing finding on renal biopsy of both native and transplanted kidneys. Understanding the underlying causes may help diagnosis and future management. The most frequent cause of CaOx crystal deposition within the kidney is hyperoxaluria. When this is seen in native kidney biopsy, primary hyperoxaluria must be considered and investigated further with biochemical and genetic tests. Secondary hyperoxaluria, for example due to enteric hyperoxaluria following bariatric surgery, ingested ethylene glycol or vitamin C overdose may also cause CaOx deposition in native kidneys. CaOx deposition is a frequent finding in renal transplant biopsy, often as a consequence of acute tubular necrosis and is associated with poorer long-term graft outcomes. CaOx crystal deposition in the renal transplant may also be secondary to any of the causes associated with this phenotype in the native kidney. The pathophysiology underlying CaOx deposition is complex but this histological phenotype may indicate serious underlying pathology and should always warrant further investigation.
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