We are analyzing https://link.springer.com/article/10.1007/s002230001186.

Title:
Multiple Cellular Phenotypes in an Insertional Mutation in Mouse Affecting Bone Development | Calcified Tissue International
Description:
The 6093 line of transgenic mice exhibits altered bone development as a result of an insertional mutation by the transgene. Female transgenic mice show a marked kyphosis as early as 2 weeks of age. Vertebrae from female mice have lower total bone area and mineral content than age-matched, gender-matched controls, although the bone mineral density is not changed. The femur and tibia exhibit the opposite effect—increased bone area and mineral content. Fluorescent bone label experiments indicated an increased rate of bone mineral deposition in the femur during the early postnatal growth period, and bone marrow from femurs of 6093 females had increased numbers of fibroblast colony-forming units. Transgenic females also are obese and have altered thymocyte development, suggesting that the insertional mutation affects multiple cell populations. We hypothesize that these phenotypes arise as a result of an alteration in the function or developmental potential of a stromal cell or mesenchymal stem cell.
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Keywords {🔍}

bone, article, content, access, oklahoma, usa, privacy, cookies, research, mutation, development, transgenic, cell, information, publish, search, insertional, mouse, mice, mineral, data, area, log, journal, tissue, multiple, phenotypes, february, nadon, doersen, lade, open, discover, springer, function, optional, personal, parties, policy, find, track, calcified, international, cellular, affecting, published, cite, medina, thompson, rohrer,

Topics {✒️}

month download article/chapter mesenchymal stem cell multiple cellular phenotypes bone marrow fibroblast colony-forming units full article pdf altered thymocyte development bone mineral density bone mineral deposition stromal cell privacy choices/manage cookies site related subjects transgenic mouse line check access instant access european economic area genetic mouse model article log scope submit manuscript human 15q11-13 duplication bone mass article cite conditions privacy policy article nadon female mice gender-matched controls accepting optional cookies insertional mutation marked kyphosis main content log journal finder publish phenotypes arise transgenic females privacy policy personal data books a optional cookies manage preferences increased rate increased numbers gimble procter gamble pharmaceuticals mineral content information data protection essential cookies cookies skip oklahoma city institution subscribe

Schema {🗺️}

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         headline:Multiple Cellular Phenotypes in an Insertional Mutation in Mouse Affecting Bone Development
         description: The 6093 line of transgenic mice exhibits altered bone development as a result of an insertional mutation by the transgene. Female transgenic mice show a marked kyphosis as early as 2 weeks of age. Vertebrae from female mice have lower total bone area and mineral content than age-matched, gender-matched controls, although the bone mineral density is not changed. The femur and tibia exhibit the opposite effect—increased bone area and mineral content. Fluorescent bone label experiments indicated an increased rate of bone mineral deposition in the femur during the early postnatal growth period, and bone marrow from femurs of 6093 females had increased numbers of fibroblast colony-forming units. Transgenic females also are obese and have altered thymocyte development, suggesting that the insertional mutation affects multiple cell populations. We hypothesize that these phenotypes arise as a result of an alteration in the function or developmental potential of a stromal cell or mesenchymal stem cell.
         datePublished:2014-02-11T00:00:00Z
         dateModified:2014-02-11T00:00:00Z
         pageStart:449
         pageEnd:454
         sameAs:https://doi.org/10.1007/s002230001186
         keywords:
            Key words: Bone — Transgenic mice — Kyphosis — Mesenchymal stem cell — Stromal cell
            Biochemistry
            general
            Endocrinology
            Orthopedics
            Cell Biology
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      headline:Multiple Cellular Phenotypes in an Insertional Mutation in Mouse Affecting Bone Development
      description: The 6093 line of transgenic mice exhibits altered bone development as a result of an insertional mutation by the transgene. Female transgenic mice show a marked kyphosis as early as 2 weeks of age. Vertebrae from female mice have lower total bone area and mineral content than age-matched, gender-matched controls, although the bone mineral density is not changed. The femur and tibia exhibit the opposite effect—increased bone area and mineral content. Fluorescent bone label experiments indicated an increased rate of bone mineral deposition in the femur during the early postnatal growth period, and bone marrow from femurs of 6093 females had increased numbers of fibroblast colony-forming units. Transgenic females also are obese and have altered thymocyte development, suggesting that the insertional mutation affects multiple cell populations. We hypothesize that these phenotypes arise as a result of an alteration in the function or developmental potential of a stromal cell or mesenchymal stem cell.
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      dateModified:2014-02-11T00:00:00Z
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      pageEnd:454
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         Key words: Bone — Transgenic mice — Kyphosis — Mesenchymal stem cell — Stromal cell
         Biochemistry
         general
         Endocrinology
         Orthopedics
         Cell Biology
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