LINK . SPRINGER . COM {}

Matching Content Categories {📚}

• Health & Fitness
• Social Networks
• Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

article, ccep, rlx, privacy, cookies, content, yen, bone, information, publish, search, raloxifene, healthy, postmenopausal, women, regimens, increased, median, access, data, log, journal, research, osteoporosis, therapy, taiwanese, tsai, pan, taiwan, bmd, compared, significantly, levels, subjects, discover, springer, optional, personal, parties, policy, find, track, international, versus, continuous, combined, estrogenprogestin, densitometric, biochemical, effects,

Topics {✒️}

month download article/chapter postmenopausal taiwanese women full article pdf privacy choices/manage cookies serum lipids increased hdl-cholesterol european economic area scope submit manuscript active-controlled fashion reported vaginal bleeding conditions privacy policy related subjects accepting optional cookies bone turnover bone health osteoporosis raloxifene journal finder publish usage analysis article log check access instant access article cite significantly larger article tsai ccep decreased privacy policy personal data osteocalcin levels books a optional cookies manage preferences subscription content similar content information data protection essential cookies cookies skip institution subscribe journal publish total cholesterol ldl-cholesterol social media varying standards biochemical effects december 2001 volume 12 double-masked hip sites urinary type lesser extent

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Raloxifene Versus Continuous Combined Estrogen/Progestin Therapy: Densitometric and Biochemical Effects in Healthy Postmenopausal Taiwanese Women
         description: We treated 116 healthy postmenopausal women (age 47–66 years, mean 57 years) in Taiwan with either raloxifene (RLX) 60 mg (n= 92) or 0.625 mg conjugated equine estrogen plus 5 mg medroxyprogesterone acetate (CCEP, n= 24) daily for 12 months in a randomized, double-masked, active-controlled fashion. The results showed that both regimens increased bone mineral density (BMD) at hip sites (means: RLX 2.5–4.9%, CCEP 4.6–7.9%, all p<0.005 compared with baseline), and the difference between the two regimens was not significant. The spinal BMD increased significantly in both groups (1.4% with RLX and 6.0% with CCEP, both p<0.01), and more with CCEP (p<0.003). Osteocalcin levels and urinary type I collagen C-telopeptide/creatinine ratios decreased significantly in both regimens, but the decreases were significantly larger with CCEP. Compared with baseline, both RLX and CCEP decreased the total cholesterol (median 4.9% and 8.6% respectively, p<0.001) and LDL-cholesterol (median 11% and 19% respectively, p<0.001), and increased HDL-cholesterol (median 8.6% and 10.7% respectively, p<0.01). Both regimens increased triglyceride levels (median 3.2% and 18.9% respectively, both p<0.05), although to a lesser extent with RLX than with CCEP (p<0.05). Only 3 subjects (3.3%) reported vaginal bleeding in the RLX group, as compared with 31% (7/22) with CCEP (p<0.05). We conclude that in healthy, postmenopausal Taiwanese women, RLX 60 mg given daily has favorable results in BMD, bone turnover and serum lipids, although the dosage we used showed a potency less than that of conventional CCEP.
         datePublished:
         dateModified:
         pageStart:1020
         pageEnd:1025
         sameAs:https://doi.org/10.1007/s001980170011
         keywords:
            Key words:BMD – Bone markers – HRT – Raloxifene – Serum lipids
            Orthopedics
            Endocrinology
            Rheumatology
         image:
         isPartOf:
            name:Osteoporosis International
            issn:
               1433-2965
               0937-941X
            volumeNumber:12
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag London Limited
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:K. S. Tsai
               affiliation:
                     name:Departments of Laboratory Medicine
                     address:
                        name:Departments of Laboratory Medicine, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. L. Yen
               affiliation:
                     name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
                     address:
                        name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
               name:H. A. Pan
               affiliation:
                     name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
                     address:
                        name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. H. Wu
               affiliation:
                     name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
                     address:
                        name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
               name:W. C. Cheng
               affiliation:
                     name:Departments of Laboratory Medicine
                     address:
                        name:Departments of Laboratory Medicine, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
               name:S. H. J. Hsu
               affiliation:
                     name:Departments of Laboratory Medicine
                     address:
                        name:Departments of Laboratory Medicine, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
               name:B. L. Yen
               affiliation:
                     name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
                     address:
                        name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
               name:K. E. Huang
               affiliation:
                     name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
                     address:
                        name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Raloxifene Versus Continuous Combined Estrogen/Progestin Therapy: Densitometric and Biochemical Effects in Healthy Postmenopausal Taiwanese Women
      description: We treated 116 healthy postmenopausal women (age 47–66 years, mean 57 years) in Taiwan with either raloxifene (RLX) 60 mg (n= 92) or 0.625 mg conjugated equine estrogen plus 5 mg medroxyprogesterone acetate (CCEP, n= 24) daily for 12 months in a randomized, double-masked, active-controlled fashion. The results showed that both regimens increased bone mineral density (BMD) at hip sites (means: RLX 2.5–4.9%, CCEP 4.6–7.9%, all p<0.005 compared with baseline), and the difference between the two regimens was not significant. The spinal BMD increased significantly in both groups (1.4% with RLX and 6.0% with CCEP, both p<0.01), and more with CCEP (p<0.003). Osteocalcin levels and urinary type I collagen C-telopeptide/creatinine ratios decreased significantly in both regimens, but the decreases were significantly larger with CCEP. Compared with baseline, both RLX and CCEP decreased the total cholesterol (median 4.9% and 8.6% respectively, p<0.001) and LDL-cholesterol (median 11% and 19% respectively, p<0.001), and increased HDL-cholesterol (median 8.6% and 10.7% respectively, p<0.01). Both regimens increased triglyceride levels (median 3.2% and 18.9% respectively, both p<0.05), although to a lesser extent with RLX than with CCEP (p<0.05). Only 3 subjects (3.3%) reported vaginal bleeding in the RLX group, as compared with 31% (7/22) with CCEP (p<0.05). We conclude that in healthy, postmenopausal Taiwanese women, RLX 60 mg given daily has favorable results in BMD, bone turnover and serum lipids, although the dosage we used showed a potency less than that of conventional CCEP.
      datePublished:
      dateModified:
      pageStart:1020
      pageEnd:1025
      sameAs:https://doi.org/10.1007/s001980170011
      keywords:
         Key words:BMD – Bone markers – HRT – Raloxifene – Serum lipids
         Orthopedics
         Endocrinology
         Rheumatology
      image:
      isPartOf:
         name:Osteoporosis International
         issn:
            1433-2965
            0937-941X
         volumeNumber:12
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag London Limited
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:K. S. Tsai
            affiliation:
                  name:Departments of Laboratory Medicine
                  address:
                     name:Departments of Laboratory Medicine, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. L. Yen
            affiliation:
                  name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
                  address:
                     name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
            name:H. A. Pan
            affiliation:
                  name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
                  address:
                     name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. H. Wu
            affiliation:
                  name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
                  address:
                     name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
            name:W. C. Cheng
            affiliation:
                  name:Departments of Laboratory Medicine
                  address:
                     name:Departments of Laboratory Medicine, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. H. J. Hsu
            affiliation:
                  name:Departments of Laboratory Medicine
                  address:
                     name:Departments of Laboratory Medicine, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
            name:B. L. Yen
            affiliation:
                  name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
                  address:
                     name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
            name:K. E. Huang
            affiliation:
                  name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
                  address:
                     name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Osteoporosis International
      issn:
         1433-2965
         0937-941X
      volumeNumber:12
Organization:
      name:Springer-Verlag London Limited
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Departments of Laboratory Medicine
      address:
         name:Departments of Laboratory Medicine, , TW
         type:PostalAddress
      name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
      address:
         name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
         type:PostalAddress
      name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
      address:
         name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
         type:PostalAddress
      name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
      address:
         name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
         type:PostalAddress
      name:Departments of Laboratory Medicine
      address:
         name:Departments of Laboratory Medicine, , TW
         type:PostalAddress
      name:Departments of Laboratory Medicine
      address:
         name:Departments of Laboratory Medicine, , TW
         type:PostalAddress
      name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
      address:
         name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
         type:PostalAddress
      name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
      address:
         name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:K. S. Tsai
      affiliation:
            name:Departments of Laboratory Medicine
            address:
               name:Departments of Laboratory Medicine, , TW
               type:PostalAddress
            type:Organization
      name:M. L. Yen
      affiliation:
            name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
            address:
               name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
               type:PostalAddress
            type:Organization
      name:H. A. Pan
      affiliation:
            name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
            address:
               name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
               type:PostalAddress
            type:Organization
      name:M. H. Wu
      affiliation:
            name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
            address:
               name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
               type:PostalAddress
            type:Organization
      name:W. C. Cheng
      affiliation:
            name:Departments of Laboratory Medicine
            address:
               name:Departments of Laboratory Medicine, , TW
               type:PostalAddress
            type:Organization
      name:S. H. J. Hsu
      affiliation:
            name:Departments of Laboratory Medicine
            address:
               name:Departments of Laboratory Medicine, , TW
               type:PostalAddress
            type:Organization
      name:B. L. Yen
      affiliation:
            name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,
            address:
               name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
               type:PostalAddress
            type:Organization
      name:K. E. Huang
      affiliation:
            name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC
            address:
               name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Departments of Laboratory Medicine, , TW
      name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
      name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
      name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
      name:Departments of Laboratory Medicine, , TW
      name:Departments of Laboratory Medicine, , TW
      name:Obstetrics & Gynecology, National Taiwan University Hospital and Medical College, Taipei,, , TW
      name:Department of Obstetrics and Gynecology, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC, , TW
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(39)

• Monthly income for https://www.springernature.com/gp/authors
• Check the income stats for https://link.springernature.com/home/
• Get to know https://order.springer.com/public/cart's earnings
• Get to know https://www.editorialmanager.com/osin/'s earnings
• https://www.springernature.com/gp/librarians/licensing/agc/journals income
• Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=K.%20S.%20Tsai
• Check the income stats for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22K.%20S.%20Tsai%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M.%20L.%20Yen
• Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M.%20L.%20Yen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=H.%20A.%20Pan gross monthly?
• What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22H.%20A.%20Pan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M.%20H.%20Wu?
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M.%20H.%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=W.%20C.%20Cheng rake in every month?
• What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22W.%20C.%20Cheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=S.%20H.%20J.%20Hsu?
• See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22S.%20H.%20J.%20Hsu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
• Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=B.%20L.%20Yen is on a monthly basis
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22B.%20L.%20Yen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
• What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=K.%20E.%20%20Huang?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22K.%20E.%20%20Huang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much income does https://s100.copyright.com/AppDispatchServlet?title=Raloxifene%20Versus%20Continuous%20Combined%20Estrogen%2FProgestin%20Therapy%3A%20Densitometric%20and%20Biochemical%20Effects%20in%20Healthy%20Postmenopausal%20Taiwanese%20Women&author=K.%20S.%20Tsai%20et%20al&contentID=10.1007%2Fs001980170011©right=International%20Osteoporosis%20Foundation%20and%20National%20Osteoporosis%20Foundation&publication=0937-941X&publicationDate=2001-12&publisherName=SpringerNature&orderBeanReset=true have?
• What's the financial gain of https://citation-needed.springer.com/v2/references/10.1007/s001980170011?format=refman&flavour=citation?
• What's the income of https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral?
• What's the revenue for https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research?
• What's https://www.springernature.com/gp/products's gross income?
• https://www.springernature.com/gp/librarians's revenue stream
• How much cash flow does https://www.springernature.com/gp/societies have monthly?
• How much does https://www.springernature.com/gp/partners rake in every month?
• https://www.springer.com/'s total income per month
• What's the monthly money flow for https://www.nature.com/?
• How much does https://www.biomedcentral.com/ net monthly?
• How much does https://www.palgrave.com/ make?
• https://www.apress.com/'s financial summary
• How much revenue does https://www.springernature.com/gp/legal/ccpa generate?
• What's the total monthly financial gain of https://www.springernature.com/gp/info/accessibility?
• How profitable is https://support.springernature.com/en/support/home?
• What's the financial intake of https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations?
• Monthly income for https://www.springernature.com/

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Clipboard.js
• Prism.js

CDN Services {📦}

• Crossref