We are analyzing https://link.springer.com/article/10.1007/s00198-013-2530-3.

Title:
Cancer-associated bone disease | Osteoporosis International
Description:
Bone is commonly affected in cancer. Cancer-induced bone disease results from the primary disease, or from therapies against the primary condition, causing bone fragility. Bone-modifying agents, such as bisphosphonates and denosumab, are efficacious in preventing and delaying cancer-related bone disease. With evidence-based care pathways, guidelines assist physicians in clinical decision-making. Of the 57 million deaths in 2008 worldwide, almost two thirds were due to non-communicable diseases, led by cardiovascular diseases and cancers. Bone is a commonly affected organ in cancer, and although the incidence of metastatic bone disease is not well defined, it is estimated that around half of patients who die from cancer in the USA each year have bone involvement. Furthermore, cancer-induced bone disease can result from the primary disease itself, either due to circulating bone resorbing substances or metastatic bone disease, such as commonly occurs with breast, lung and prostate cancer, or from therapies administered to treat the primary condition thus causing bone loss and fractures. Treatment-induced osteoporosis may occur in the setting of glucocorticoid therapy or oestrogen deprivation therapy, chemotherapy-induced ovarian failure and androgen deprivation therapy. Tumour skeletal-related events include pathologic fractures, spinal cord compression, surgery and radiotherapy to bone and may or may not include hypercalcaemia of malignancy while skeletal complication refers to pain and other symptoms. Some evidence demonstrates the efficacy of various interventions including bone-modifying agents, such as bisphosphonates and denosumab, in preventing or delaying cancer-related bone disease. The latter includes treatment of patients with metastatic skeletal lesions in general, adjuvant treatment of breast and prostate cancer in particular, and the prevention of cancer-associated bone disease. This has led to the development of guidelines by several societies and working groups to assist physicians in clinical decision making, providing them with evidence-based care pathways to prevent skeletal-related events and bone loss. The goal of this paper is to put forth an IOF position paper addressing bone diseases and cancer and summarizing the position papers of other organizations.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, pubmed, cancer, bone, cas, breast, prostate, osteoporosis, oncol, clin, treatment, women, patients, loss, therapy, clinical, adjuvant, disease, study, aromatase, acid, trial, risk, res, zoledronic, fracture, myeloma, men, deprivation, androgen, med, postmenopausal, mineral, density, osteoporos, metastatic, fractures, prevention, metastases, coleman, int, multiple, bisphosphonates, denosumab, society, randomized, body, guidelines, rev,

Topics {✒️}

prevent skeletal-related events gonadotropin-releasing hormone agonists month download article/chapter parathyroid hormone-related protein evidence-based care pathways wnt-signaling antagonist dkk1 hormone-responsive breast cancer //clinicaltrialsgov/ct2/show/nct00127205 //wwwclinicaltrialsgov/ct2/show/nct00556374 ghada el-hajj fuleihan chemotherapy-induced bone loss cancer-induced bone disease prostate-bed radiation therapy chemotherapy-induced ovarian failure university campus bio-medico castrate-resistant prostate cancer annual zoledronic acid breast-cancer adjuvant therapy castration-resistant prostate cancer 5-fluorouracil–doxorubicin–cyclophosphamide fdg anastrozole-induced bone loss term=s0307&rank=2 early-stage breast cancer bone loss induced metabolic bone disorders oestrogen deprivation therapy el hajj fuleihan catherine van poznak chemical castration induced received research support van geel ta pivotal randomized double-blind androgen deprivation therapy androgen-deprivation therapy mineral research unit privacy choices/manage cookies abdellah el maghraoui van aken jb bone mineral density received research grants adjuvant zoledronic acid initial adjuvant therapy osteoprotegerin pdgf-bb b-cell malignancies dose–response relationships full article pdf early breast cancer androgen deprivation initiation consensus position statement causing bone loss

Questions {❓}

Rizzoli R (2011) Bisphosphonates for post-menopausal osteoporosis: are they all the same?
Wadhwa VK, Parr NJ (2009) Peripheral or axial bone density measurements to identify osteoporosis in prostate cancer patients undergoing androgen deprivation therapy?
Http://clinicaltrialsgov/ct2/show/NCT00127205?
Http://wwwclinicaltrialsgov/ct2/show/NCT00556374?

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