LINK . SPRINGER . COM {}

Matching Content Categories {📚}

• Health & Fitness
• Education
• Insurance

Content Management System {📝}

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Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

• Payton ME, Greenstone MH, Schenker N (2003) Overlapping confidence intervals or standard error intervals: what do they mean in terms of statistical significance?

Schema {🗺️}

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         headline:Intensive care support and clinical outcomes of patients with Ebola virus disease (EVD) in West Africa
         description:We investigate the impact on outcome of different levels of supportive treatment in Ebola virus disease (EVD). The NGO EMERGENCY delivered care sequentially at two Ebola Treatment Centres (ETC) in Sierra Leone: first at Lakka (fluids, symptomatic, antibiotic, antimalaria treatment, and hospital level medical care), and thereafter in Goderich, adding organ support in the only African ETC with an equipped and staffed intensive care unit (ETC-ICU). The primary outcome in this retrospective cohort study was in-ETC mortality. Secondarily, we used multivariable logistic regression to investigate the independent impact of the IC on mortality by comparing patients in two ETCs, adjusting for potential confounders, including the viral load (base-10 logarithm in copies/ml) (LVL), modelled as a piecewise linear function. Mortality was plotted versus LVL. Confidence bands were constructed by a bootstrap technique. The number of hospital-free days within 28 was computed to assess the burden of EVD. Data from 229 EVD patients were analysed (123 in Lakka, 106 in Goderich). Crude analysis showed a non-statistically significant difference in mortality (57.7% in Lakka vs 50.0% in Goderich; p = 0.19). Age and LVL were associated with mortality. Adjusted mortality was lower at the Goderich ICU-ETC (p = 0.055). This difference was observed with 80% confidence for patients with LVL between 7.5 and 8.5 copies/ml. Hospital-free days (of 28 days) were greater (7.7 vs 5.5; p = 0.03) for patients treated in the ICU-ETC. Provision of critical care to patients with EVD is feasible in resource-limited settings and was associated with improved survival and less time in hospital.
         datePublished:2018-07-30T00:00:00Z
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      headline:Intensive care support and clinical outcomes of patients with Ebola virus disease (EVD) in West Africa
      description:We investigate the impact on outcome of different levels of supportive treatment in Ebola virus disease (EVD). The NGO EMERGENCY delivered care sequentially at two Ebola Treatment Centres (ETC) in Sierra Leone: first at Lakka (fluids, symptomatic, antibiotic, antimalaria treatment, and hospital level medical care), and thereafter in Goderich, adding organ support in the only African ETC with an equipped and staffed intensive care unit (ETC-ICU). The primary outcome in this retrospective cohort study was in-ETC mortality. Secondarily, we used multivariable logistic regression to investigate the independent impact of the IC on mortality by comparing patients in two ETCs, adjusting for potential confounders, including the viral load (base-10 logarithm in copies/ml) (LVL), modelled as a piecewise linear function. Mortality was plotted versus LVL. Confidence bands were constructed by a bootstrap technique. The number of hospital-free days within 28 was computed to assess the burden of EVD. Data from 229 EVD patients were analysed (123 in Lakka, 106 in Goderich). Crude analysis showed a non-statistically significant difference in mortality (57.7% in Lakka vs 50.0% in Goderich; p = 0.19). Age and LVL were associated with mortality. Adjusted mortality was lower at the Goderich ICU-ETC (p = 0.055). This difference was observed with 80% confidence for patients with LVL between 7.5 and 8.5 copies/ml. Hospital-free days (of 28 days) were greater (7.7 vs 5.5; p = 0.03) for patients treated in the ICU-ETC. Provision of critical care to patients with EVD is feasible in resource-limited settings and was associated with improved survival and less time in hospital.
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      dateModified:2018-07-30T00:00:00Z
      pageStart:1266
      pageEnd:1275
      sameAs:https://doi.org/10.1007/s00134-018-5308-4
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         Ebola virus disease
         Intensive care
         Multiple organ failure
         Health-care in resource limited countries
         Intensive / Critical Care Medicine
         Anesthesiology
         Emergency Medicine
         Pneumology/Respiratory System
         Pain Medicine
         Pediatrics
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      name:EMERGENCY-NGO, Milan, Italy
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      name:Dipartimento di Epidemiologia Clinica, IRCCS Istituto di Ricerche Farmacologiche “Mario Negri”, Ranica, Italy
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      name:IRCCS Istituto Nazionale Malattie Infettive “Lazzaro Spallanzani”, Rome, Italy
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      name:EMERGENCY-NGO, Milan, Italy
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      name:Dipartimento di Epidemiologia Clinica, IRCCS Istituto di Ricerche Farmacologiche “Mario Negri”, Ranica, Italy
      name:EMERGENCY-NGO, Milan, Italy

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