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Topics {✒️}

gas chromatography/mass spectrometry pro-inflammatory cytokine expression related subjects privacy choices/manage cookies blood flow responses type ii diabetes improves endothelial function treated ten normotensive reduces oxidative stress oxidative stress parameters main content log european economic area enzymic oxidation product forearm vasodilator responses brachial artery infusion strain gauge plethysmography n-3 fatty acids conditions privacy policy accepting optional cookies scope submit manuscript oral treatment search search hospital medical college plasma 8-epi-pgf2α clinical pharmacology journal finder publish article cite article chowienczyk type ii oxidative stress type 2 diabetic august 2000 volume 43 russell-jones privacy policy personal data diabetes mellitus latest articles books a optional cookies manage preferences 8-epi-pgf2α angiotensin ii diabetic men data protection essential cookies cookies skip 30 μg min–1 10 μg min–1 plasma concentrations journal publish

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WebPage:
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         headline:Oral treatment with an antioxidant (raxofelast) reduces oxidative stress and improves endothelial function in men with Type II diabetes
         description: Aims/hypothesis. To determine whether raxofelast, a new water soluble antioxidant decreases oxidative stress and improves endothelial function in men with Type II (non-insulin dependent) diabetes mellitus. Methods. We treated ten normotensive, normocholesterolaemic men with Type II diabetes and as controls ten healthy men matched with them for age with raxofelast (600 mg twice daily) for 1 week. Plasma 8-epi-PGF2α, a non-enzymic oxidation product of arachidonic acid was measured by gas chromatography/mass spectrometry as an index of oxidative stress. Forearm vasodilator responses to brachial artery infusion of acetylcholine (7.5, 15 and 30 μg min–1) and of the nitric oxide donor nitroprusside (1, 3 and 10 μg min–1) were measured by strain gauge plethysmography. Results. Plasma concentrations of 8-epi-PGF2α were greater in diabetic than in control men (0.99 ± 0.20 vs 0.18 ± 0.01 nmol l–1, means ± SEM, p < 0.001) and fell after raxofelast (from 0.99 ± 0.20 to 0.47 ± 0.07 nmol l–1, p < 0.05) in diabetic men but not in control men. Blood flow responses to acetylcholine were lower (p < 0.05) in diabetic than in control men (7.4 ± 1.0 vs 12.9 ± 2.3 ml · min–1· 100 ml–1 for the highest dose). In diabetic men, but not in control men, raxofelast increased (p < 0.05) blood flow responses to acetylcholine (from 7.4 ± 1.0 ml · min–1· 100 ml–1 to 11.3 ± 2.3 ml · min–1· 100 ml–1 at highest dose). Blood flow responses to nitroprusside were similar in control and diabetic men and in both groups were similar before and after raxofelast. Conclusion/interpretation. Oral treatment with raxofelast for 1 week reduces oxidative stress and improves endothelial function in men with Type II diabetes. [Diabetologia (2000) 43: 974–977]
         datePublished:
         dateModified:
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         sameAs:https://doi.org/10.1007/s001250051478
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            Keywords Acetylcholine
            endothelium
            free radicals
            lipid peroxidation
            nitric oxide
            prostaglandins.
            Internal Medicine
            Metabolic Diseases
            Human Physiology
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               1432-0428
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      headline:Oral treatment with an antioxidant (raxofelast) reduces oxidative stress and improves endothelial function in men with Type II diabetes
      description: Aims/hypothesis. To determine whether raxofelast, a new water soluble antioxidant decreases oxidative stress and improves endothelial function in men with Type II (non-insulin dependent) diabetes mellitus. Methods. We treated ten normotensive, normocholesterolaemic men with Type II diabetes and as controls ten healthy men matched with them for age with raxofelast (600 mg twice daily) for 1 week. Plasma 8-epi-PGF2α, a non-enzymic oxidation product of arachidonic acid was measured by gas chromatography/mass spectrometry as an index of oxidative stress. Forearm vasodilator responses to brachial artery infusion of acetylcholine (7.5, 15 and 30 μg min–1) and of the nitric oxide donor nitroprusside (1, 3 and 10 μg min–1) were measured by strain gauge plethysmography. Results. Plasma concentrations of 8-epi-PGF2α were greater in diabetic than in control men (0.99 ± 0.20 vs 0.18 ± 0.01 nmol l–1, means ± SEM, p < 0.001) and fell after raxofelast (from 0.99 ± 0.20 to 0.47 ± 0.07 nmol l–1, p < 0.05) in diabetic men but not in control men. Blood flow responses to acetylcholine were lower (p < 0.05) in diabetic than in control men (7.4 ± 1.0 vs 12.9 ± 2.3 ml · min–1· 100 ml–1 for the highest dose). In diabetic men, but not in control men, raxofelast increased (p < 0.05) blood flow responses to acetylcholine (from 7.4 ± 1.0 ml · min–1· 100 ml–1 to 11.3 ± 2.3 ml · min–1· 100 ml–1 at highest dose). Blood flow responses to nitroprusside were similar in control and diabetic men and in both groups were similar before and after raxofelast. Conclusion/interpretation. Oral treatment with raxofelast for 1 week reduces oxidative stress and improves endothelial function in men with Type II diabetes. [Diabetologia (2000) 43: 974–977]
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         Keywords Acetylcholine
         endothelium
         free radicals
         lipid peroxidation
         nitric oxide
         prostaglandins.
         Internal Medicine
         Metabolic Diseases
         Human Physiology
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      name:Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King's College, London, UK, , GB
      name:The William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, UK, , GB
      name:Department of Diabetes and Endocrinology, King's College, London, UK, , GB
      name:Biomedica Foscama, Rome, Italy, , IT
      name:Department of Diabetes and Endocrinology, King's College, London, UK, , GB
      name:The William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, UK, , GB
      name:Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King's College, London, UK, , GB

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