We are analyzing https://link.springer.com/article/10.1007/s00125-016-3933-4.

Title:
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues | Diabetologia
Description:
White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. However, in the context of sustained obesity, WAT undergoes fibro-inflammation, which compromises its functionality, contributing to increased risk of type 2 diabetes and cardiovascular diseases. Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities.
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Keywords {🔍}

pubmed, article, google, scholar, cas, adipocytes, adipose, tissue, adipocyte, adipogenesis, cell, central, white, sat, cells, obesity, brown, wat, vat, fat, mice, metabolic, bat, human, differentiation, depots, expansion, precursors, beige, ecm, expression, metab, fibrosis, factor, factors, bmp, activation, humans, protein, diabetes, subcutaneous, development, differences, preadipocytes, plasticity, obese, study, remodelling, studies, aps,

Topics {✒️}

peroxisome proliferator-activated receptor-γ lin−/cd34+/cd29+/sca-1+/cd24+ cells native cd45−/cd34+/cd31− cells sox10-cre/rosa26-yfp model bone-marrow-derived circulating progenitors fatty-acid-dependent ucp1 uncoupling rosa-floxed stop-lacz mouse bone-marrow-derived adipocytes arise platelet-derived growth factor wellcome trust-mrc institute article download pdf antonio vidal-puig lin−sca1+cd29+cd34+ bone-marrow-derived cells ccat/enhancer-binding proteins whri-academy postdoctoral fellowship fat-mediated thermo-insulation white/brown/brite adipocyte progenitors genetic/genomics data obtained green fluorescent protein-expressing mt/mg mouse model endothelial marker ve-cadherin male c57bl/6j mice creert-inducible mice crossed nes-cre/tomato+ cells growth-arrested pre-adipocytes close temporal–spatial association bat-derived precursors showing targeting tissue plasticity/remodelling cdh5-derived adipocyte precursors main pro-angiogenic factor cold-induced ucp1 expression peri-adrenal wat derives peri-adrenal fat depot perilipin+/adiponectin+ pre-adipocytes human sat-derived svf adipocyte size/ap pool chronic fibro-inflammatory environment cilair-based secretome analysis vivo lineage-tracing approach white adipocyte trans-differentiation van de wall cold-induced brown adipocytes lee y direct central role pre-existing brown adipocytes subsequent lineage-tracing studies rodent beige/brite cells gata-binding protein 2 brown-specific thermogenic markers

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         description:White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. However, in the context of sustained obesity, WAT undergoes fibro-inflammation, which compromises its functionality, contributing to increased risk of type 2 diabetes and cardiovascular diseases. Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities.
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      headline:Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
      description:White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. However, in the context of sustained obesity, WAT undergoes fibro-inflammation, which compromises its functionality, contributing to increased risk of type 2 diabetes and cardiovascular diseases. Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities.
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         Type 2 diabetes
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         Metabolic Diseases
         Human Physiology
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