We are analyzing https://link.springer.com/article/10.1007/s00125-006-0140-8.

Title:
Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells | Diabetologia
Description:
Aims/hypothesis The aim of this study was to investigate the effects of liver X receptor (LXR) activation on lipid metabolism and insulin action in human skeletal muscle cells prepared from control subjects and from patients with type 2 diabetes. Subjects and methods Cultured myotubes were obtained from muscle biopsies of 11 lean, healthy control subjects and ten patients with type 2 diabetes. The mRNA levels of LXR isoforms and lipogenic genes were estimated by RT-quantitative PCR, and the effects of LXR agonists on insulin action were evaluated by assays of protein kinase B serine 473 phosphorylation and glycogen synthesis. Results Both LXRα and LXRβ were expressed in human skeletal muscle and adipose tissue and there was no difference in their mRNA abundance in tissues from patients with type 2 diabetes compared with control subjects. In cultured muscle cells, LXR activation by T0901317 strongly increased expression of the genes encoding lipogenic enzymes, including sterol regulatory element binding protein 1c, fatty acid synthase and stearoyl-CoA desaturase 1, and also promoted triglyceride accumulation in the presence of a high glucose concentration. Importantly, these effects on lipid metabolism did not affect protein kinase B activation by insulin. Furthermore, LXR agonists did not modify insulin action in muscle cells from patients with type 2 diabetes. Conclusions/interpretation These data suggest that LXR agonists may lead to increased utilisation of lipids and glucose in muscle cells without affecting the mechanism of action of insulin. However, the long-term consequences of triglyceride accumulation in muscle should be evaluated before the development of effective LXR-based therapeutic agents.
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Keywords {🔍}

insulin, muscle, lxr, cells, diabetes, human, skeletal, patients, glucose, type, expression, google, scholar, subjects, activation, myotubes, action, mrna, effect, srebpc, data, accumulation, fatty, control, lipid, protein, gene, fig, effects, levels, mmoll, genes, pkb, metabolism, adipose, tissue, acid, diabetic, liver, glycogen, receptor, agonists, condition, synthesis, expressed, sterol, regulatory, shown, differentiated, lxrα,

Topics {✒️}

long-chain acetyl-coas db/db diabetic mouse peroxisome proliferator-activated receptors quantitative real-time pcr parametric mann–whitney test rate-limiting enzyme catalysing mono-unsaturated fatty acids anti-phospho-ser473 antibody irs1/pi3kinase/pkb pathway real-time rt-qpcr fatty acid-induced lipotoxicity ten age-matched patients euglycaemic–hyperinsulinaemic clamp showed 4 amol/μg total rna insulin-dependent diabetes mellitus steady-state mrna levels dual luciferase assay fatty acid translocase transcription factor privacy choices/manage cookies adenovirus-mediated overexpression affect protein kinase insulin signalling pathway circulating fatty acid pkb signalling pathway saturated fatty acids fatty acid synthase stearoyl-coa desaturase 1 phosphorylated protein kinase human gene promoter total protein extract luciferase reporter constructs unsaturated fatty acids vastus lateralis muscle prl-cmv vector precursor protein levels rt-quantitative pcr fatty acid oxidation potential therapeutic agents de novo lipogenesis lxr-induced lipogenesis affected relative luciferase activity impaired glucose tolerance oxidise fatty acids fatty acid metabolism insulin-induced glycogen synthesis de la recherche faculté de médecine srebp1c promoter region lipogenesis-related genes

Schema {🗺️}

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      headline:Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells
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      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:Human Nutrition Research Center of Lyon, Lyon, France
      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:Human Nutrition Research Center of Lyon, Lyon, France
      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:Human Nutrition Research Center of Lyon, Lyon, France
      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:Human Nutrition Research Center of Lyon, Lyon, France
      name:Department of Pharmacology, Fournier-Pharma, Daix, France
      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:INSERM U449, INRA U1235, Laennec Faculty of Medicine, Claude Bernard University of Lyon, Lyon, France
      name:UMR INSERM U-449/INRA-1235, Faculté de Médecine R Laennec, Lyon, France

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