We are analyzing https://link.springer.com/article/10.1007/s001090050122.

Title:
Are Canadian Inuit at increased genetic risk for coronary heart disease? | Journal of Molecular Medicine
Description:
The Keewatin Inuit of the Northwest Territories of Canada have a very low age-adjusted mortality rate from coronary heart disease. We hypothesized that this apparent protection from disease has a genetic basis. We determined the prevalence of the disease-associated alleles of five candidate genes for atherosclerosis-related phenotypes. Surprisingly, four of the five alleles studied, namely AGT T235, FABP2 T54, PON R192 and APOE E4, were significantly more frequent in a sample of 175 Keewatin Inuit than among a representative control sample of whites living in the region. The high frequencies of these disease-associated alleles suggests either that they have no relationship with disease susceptibility in the Inuit, or that some unmeasured genetic and/or environmental factors mitigate disease susceptibility that is associated with these alleles. This highlights the difficulty in extrapolating findings from one population to another. Also, very modest genotype-phenotype associations were observed between APOE genotype (P=0.016) and plasma low-density lipoprotein cholesterol concentration and between FABP2 genotype and plasma 2-h postprandial glucose concentration (P=0.048). The relationship between APOE alleles and plasma low-density lipoprotein cholesterol was the same as has been previously reported in many study samples. However, the relationship between FABP2 alleles and plasma 2-h postprandial glucose concentrations was the opposite to that reported in other studies. This suggests that differences in environment, such as the type of fatty acid consumed, interacts with functional differences in gene products involved in candidate metabolic pathways to produce phenotypic differences.
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article, research, genetic, disease, alleles, privacy, cookies, content, journal, inuit, coronary, access, information, publish, search, medicine, risk, canada, apoe, genotype, plasma, association, toronto, health, data, log, heart, hegele, young, connelly, fabp, relationship, differences, gene, products, discover, biochemistry, university, sciences, springer, optional, analysis, personal, parties, protection, policy, find, track, molecular, canadian,

Topics {✒️}

fatty acid consumed modest genotype-phenotype associations month download article/chapter increased genetic risk community health sciences gene products involved privacy choices/manage cookies dna research laboratory postprandial glucose concentration full article pdf related subjects study samples original article published genetic basis unmeasured genetic atherosclerosis-related phenotypes coronary heart disease coronary artery disease european economic area scope submit manuscript postprandial glucose concentrations hakka postmenopausal women ontario m5b 1w8 check access instant access conditions privacy policy candidate metabolic pathways gene polymorphism accepting optional cookies molecular medicine aims representative control sample produce phenotypic differences journal finder publish main content log association apoe genotype fabp2 genotype article journal article hegele disease susceptibility article log risk factors privacy policy personal data usage analysis april 1997 volume 75 books a article cite optional cookies information

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Are Canadian Inuit at increased genetic risk for coronary heart disease?
Are Canadian Inuit at increased genetic risk for coronary heart disease?

Schema {🗺️}

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         headline:Are Canadian Inuit at increased genetic risk for coronary heart disease?
         description: The Keewatin Inuit of the Northwest Territories of Canada have a very low age-adjusted mortality rate from coronary heart disease. We hypothesized that this apparent protection from disease has a genetic basis. We determined the prevalence of the disease-associated alleles of five candidate genes for atherosclerosis-related phenotypes. Surprisingly, four of the five alleles studied, namely AGT T235, FABP2 T54, PON R192 and APOE E4, were significantly more frequent in a sample of 175 Keewatin Inuit than among a representative control sample of whites living in the region. The high frequencies of these disease-associated alleles suggests either that they have no relationship with disease susceptibility in the Inuit, or that some unmeasured genetic and/or environmental factors mitigate disease susceptibility that is associated with these alleles. This highlights the difficulty in extrapolating findings from one population to another. Also, very modest genotype-phenotype associations were observed between APOE genotype (P=0.016) and plasma low-density lipoprotein cholesterol concentration and between FABP2 genotype and plasma 2-h postprandial glucose concentration (P=0.048). The relationship between APOE alleles and plasma low-density lipoprotein cholesterol was the same as has been previously reported in many study samples. However, the relationship between FABP2 alleles and plasma 2-h postprandial glucose concentrations was the opposite to that reported in other studies. This suggests that differences in environment, such as the type of fatty acid consumed, interacts with functional differences in gene products involved in candidate metabolic pathways to produce phenotypic differences.
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            Key words Angiotensin-converting enzyme
            Angiotensinogen
            Apolipoproteins
            Fatty acid binding protein
            Paraoxonase
            Genetic predisposition
            Molecular Medicine
            Human Genetics
            Internal Medicine
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      headline:Are Canadian Inuit at increased genetic risk for coronary heart disease?
      description: The Keewatin Inuit of the Northwest Territories of Canada have a very low age-adjusted mortality rate from coronary heart disease. We hypothesized that this apparent protection from disease has a genetic basis. We determined the prevalence of the disease-associated alleles of five candidate genes for atherosclerosis-related phenotypes. Surprisingly, four of the five alleles studied, namely AGT T235, FABP2 T54, PON R192 and APOE E4, were significantly more frequent in a sample of 175 Keewatin Inuit than among a representative control sample of whites living in the region. The high frequencies of these disease-associated alleles suggests either that they have no relationship with disease susceptibility in the Inuit, or that some unmeasured genetic and/or environmental factors mitigate disease susceptibility that is associated with these alleles. This highlights the difficulty in extrapolating findings from one population to another. Also, very modest genotype-phenotype associations were observed between APOE genotype (P=0.016) and plasma low-density lipoprotein cholesterol concentration and between FABP2 genotype and plasma 2-h postprandial glucose concentration (P=0.048). The relationship between APOE alleles and plasma low-density lipoprotein cholesterol was the same as has been previously reported in many study samples. However, the relationship between FABP2 alleles and plasma 2-h postprandial glucose concentrations was the opposite to that reported in other studies. This suggests that differences in environment, such as the type of fatty acid consumed, interacts with functional differences in gene products involved in candidate metabolic pathways to produce phenotypic differences.
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      dateModified:
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      pageEnd:370
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         Key words Angiotensin-converting enzyme
         Angiotensinogen
         Apolipoproteins
         Fatty acid binding protein
         Paraoxonase
         Genetic predisposition
         Molecular Medicine
         Human Genetics
         Internal Medicine
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