We are analyzing https://link.springer.com/article/10.1007/s00109-010-0701-7.

Title:
The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc | Journal of Molecular Medicine
Description:
Histone deacetylases (HDACs) play fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. Although HDACs are recognized to be closely related to cancer development and altered expression of certain HDACs is observed in tumor samples, the arcane characters of HDACs in tumorigenesis have not been fully illustrated. Herein, we report that HDAC7 is a crucial player in cancer cell proliferation. Knockdown of HDAC7 resulted in significant G1/S arrest in different cancer cell lines. Subsequent investigations indicated that HDAC7 silencing blocked cell cycle progression through suppressing c-Myc expression and increasing p21 and p27 protein levels. The ectopic expression of c-Myc in turn antagonized the cell cycle arrest and repressed the elevation of p21 and p27 in HDAC7 silencing setting. Of note, HDAC7 deficiency was further identified to induce cellular senescence program, which was also reversed by c-Myc re-expression. Further chromatin immunoprecipitation assays indicated that HDAC7 directly binds with c-Myc gene and HDAC7 silencing decreased c-Myc mRNA level via reducing histone H3/H4 acetylation and repressing the association of RNA polymerase II (RNAP II) with c-Myc gene. Taken together, our findings highlight for the first time an unrecognized link between HDAC7 and c-Myc and offer a novel mechanistic insight into the contribution of HDAC7 to tumor progression.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, cas, google, scholar, pubmed, histone, hdac, cell, deacetylase, cmyc, cancer, expression, biol, mol, chen, gene, access, sci, usa, privacy, cookies, content, journal, research, regulation, apoptosis, senescence, nat, inhibitors, proc, natl, acad, myc, publish, search, proliferation, deacetylases, hdacs, silencing, activity, genes, proteins, marks, rev, dequiedt, class, chem, van, inhibitor, data,

Topics {✒️}

month download article/chapter jian ding & meiyu geng bypassing ras-induced senescence pbabe-puro-mycer plasmids histone deacetylase reveals hypoxia-inducible factor 1alpha c-myc/max dimerization cell cycle arrest suppressing c-myc expression cancer cells hdac7 silencing setting histone deacetylase inhibitors full article pdf privacy choices/manage cookies cancer cell lines c-myc gene usage analysis cancer cell proliferation innovation research group dna binding heterologous proteins rna polymerase ii signal pathway essential human leukemic lymphoblasts cdk inhibitor influences hdac7 directly binds check access knowledge innovation program instant access jian ding meiyu geng c-myc inactivation article zhu european economic area molecular medicine aims play fundamental roles chromatin immunoprecipitation assays related subjects single oncogenic lesion selective inhibition enhances oncogenic cooperation xiao-yong zhang state key laboratory electronic supplementary material histone deacetylases myc-regulated mirna conditions privacy policy cellular senescence article journal histone deacetylase 7

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc
         description:Histone deacetylases (HDACs) play fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. Although HDACs are recognized to be closely related to cancer development and altered expression of certain HDACs is observed in tumor samples, the arcane characters of HDACs in tumorigenesis have not been fully illustrated. Herein, we report that HDAC7 is a crucial player in cancer cell proliferation. Knockdown of HDAC7 resulted in significant G1/S arrest in different cancer cell lines. Subsequent investigations indicated that HDAC7 silencing blocked cell cycle progression through suppressing c-Myc expression and increasing p21 and p27 protein levels. The ectopic expression of c-Myc in turn antagonized the cell cycle arrest and repressed the elevation of p21 and p27 in HDAC7 silencing setting. Of note, HDAC7 deficiency was further identified to induce cellular senescence program, which was also reversed by c-Myc re-expression. Further chromatin immunoprecipitation assays indicated that HDAC7 directly binds with c-Myc gene and HDAC7 silencing decreased c-Myc mRNA level via reducing histone H3/H4 acetylation and repressing the association of RNA polymerase II (RNAP II) with c-Myc gene. Taken together, our findings highlight for the first time an unrecognized link between HDAC7 and c-Myc and offer a novel mechanistic insight into the contribution of HDAC7 to tumor progression.
         datePublished:2010-12-01T00:00:00Z
         dateModified:2010-12-01T00:00:00Z
         pageStart:279
         pageEnd:289
         sameAs:https://doi.org/10.1007/s00109-010-0701-7
         keywords:
            HDAC7
            c-Myc
            Cell cycle
            Senescence
            Transcription
            Molecular Medicine
            Human Genetics
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig5_HTML.gif
         isPartOf:
            name:Journal of Molecular Medicine
            issn:
               1432-1440
               0946-2716
            volumeNumber:89
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Caihua Zhu
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qin Chen
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zuoquan Xie
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jing Ai
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Linjiang Tong
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jian Ding
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Meiyu Geng
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc
      description:Histone deacetylases (HDACs) play fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. Although HDACs are recognized to be closely related to cancer development and altered expression of certain HDACs is observed in tumor samples, the arcane characters of HDACs in tumorigenesis have not been fully illustrated. Herein, we report that HDAC7 is a crucial player in cancer cell proliferation. Knockdown of HDAC7 resulted in significant G1/S arrest in different cancer cell lines. Subsequent investigations indicated that HDAC7 silencing blocked cell cycle progression through suppressing c-Myc expression and increasing p21 and p27 protein levels. The ectopic expression of c-Myc in turn antagonized the cell cycle arrest and repressed the elevation of p21 and p27 in HDAC7 silencing setting. Of note, HDAC7 deficiency was further identified to induce cellular senescence program, which was also reversed by c-Myc re-expression. Further chromatin immunoprecipitation assays indicated that HDAC7 directly binds with c-Myc gene and HDAC7 silencing decreased c-Myc mRNA level via reducing histone H3/H4 acetylation and repressing the association of RNA polymerase II (RNAP II) with c-Myc gene. Taken together, our findings highlight for the first time an unrecognized link between HDAC7 and c-Myc and offer a novel mechanistic insight into the contribution of HDAC7 to tumor progression.
      datePublished:2010-12-01T00:00:00Z
      dateModified:2010-12-01T00:00:00Z
      pageStart:279
      pageEnd:289
      sameAs:https://doi.org/10.1007/s00109-010-0701-7
      keywords:
         HDAC7
         c-Myc
         Cell cycle
         Senescence
         Transcription
         Molecular Medicine
         Human Genetics
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0701-7/MediaObjects/109_2010_701_Fig5_HTML.gif
      isPartOf:
         name:Journal of Molecular Medicine
         issn:
            1432-1440
            0946-2716
         volumeNumber:89
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Caihua Zhu
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qin Chen
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zuoquan Xie
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jing Ai
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Linjiang Tong
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jian Ding
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Meiyu Geng
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Molecular Medicine
      issn:
         1432-1440
         0946-2716
      volumeNumber:89
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Chinese Academy of Sciences
      address:
         name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Caihua Zhu
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Qin Chen
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Zuoquan Xie
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Jing Ai
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Linjiang Tong
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Jian Ding
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Meiyu Geng
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
      name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
      name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
      name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
      name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
      name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
      name:Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(135)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.59s.

LINK . SPRINGER . COM {}