We are analyzing https://link.springer.com/article/10.1007/s00109-009-0481-0.

Title:
Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps | Journal of Molecular Medicine
Description:
The formation of extracellular traps (ETs) by phagocytic cells has been recognized as a novel and important mechanism of the host innate immune response against infections. ETs are formed by different host immune cells such as neutrophils, mast cells, and eosinophils after stimulation with mitogens, cytokines, or pathogens themselves, in a process dependent upon induction of a reactive-oxygen-species-mediated signaling cascade. ETs consist of nuclear or mitochondrial DNA as a backbone with embedded antimicrobial peptides, histones, and cell-specific proteases and thereby provide a matrix to entrap and kill microbes and to induce the contact system. This review summarizes the latest research on ETs and their role in innate immunity and host innate defense. Attention is also given to mechanisms by which certain leading bacterial pathogens have evolved to avoid entrapment and killing in these specialized structures.
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Keywords {🔍}

article, extracellular, google, scholar, pubmed, cas, nets, neutrophil, traps, neutrophils, innate, formation, cell, antimicrobial, bacterial, ets, killing, defense, immune, dna, net, nizet, host, human, cells, pathogens, table, immunol, mast, dnase, response, eosinophils, role, pyogenes, immunity, histones, microbes, mechanisms, pathogen, bacteria, production, nuclear, protein, activity, recently, eosinophil, infection, function, access, full,

Topics {✒️}

maren von köckritz-blickwede reactive-oxygen-species-mediated signaling cascade nonenzymatic high-molecular-weight cofactor von köckritz-blickwede recurrent life-threatening bacterial article download pdf table 1 factors eosinophil-derived ets remains classical virulence factor catapulting mitochondria gene-encoded surface modifications phagocytosis-independent antimicrobial activity victor nizet beta-hydroxybutyrate abrogates formation embedded antimicrobial peptides cationic antimicrobial peptides platelet-mediated neutrophil activation shigella-induced experimental dysentery extracellular trap formation cathelicidin antimicrobial peptides reactive oxygen species potent broad-spectrum amps effector-triggered immunity ifn-α/γ + c5a innate immune system innate immune deficiency innate immunity surface-expressed m1 protein innate immune defense phagocyte extracellular traps human mast cells innate immune response il-8 protease spycep/scpc surface lipoteichoic acid neutrophil extracellular traps extracellular antimicrobial activity host immune cells privacy choices/manage cookies host innate defense innate host defense mc-specific granule proteins related subjects sialic acid moieties based immune clearance author information authors dead cell generating additional cell types tlr4-dependent fashion cathelicidin antimicrobial peptide eosinophil remains viable

Questions {❓}

Gupta AK, Hasler P, Holzgreve W, Hahn S (2007) Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?

Schema {🗺️}

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         headline:Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps
         description:The formation of extracellular traps (ETs) by phagocytic cells has been recognized as a novel and important mechanism of the host innate immune response against infections. ETs are formed by different host immune cells such as neutrophils, mast cells, and eosinophils after stimulation with mitogens, cytokines, or pathogens themselves, in a process dependent upon induction of a reactive-oxygen-species-mediated signaling cascade. ETs consist of nuclear or mitochondrial DNA as a backbone with embedded antimicrobial peptides, histones, and cell-specific proteases and thereby provide a matrix to entrap and kill microbes and to induce the contact system. This review summarizes the latest research on ETs and their role in innate immunity and host innate defense. Attention is also given to mechanisms by which certain leading bacterial pathogens have evolved to avoid entrapment and killing in these specialized structures.
         datePublished:2009-05-16T00:00:00Z
         dateModified:2009-05-16T00:00:00Z
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            Molecular Medicine
            Human Genetics
            Internal Medicine
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      headline:Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps
      description:The formation of extracellular traps (ETs) by phagocytic cells has been recognized as a novel and important mechanism of the host innate immune response against infections. ETs are formed by different host immune cells such as neutrophils, mast cells, and eosinophils after stimulation with mitogens, cytokines, or pathogens themselves, in a process dependent upon induction of a reactive-oxygen-species-mediated signaling cascade. ETs consist of nuclear or mitochondrial DNA as a backbone with embedded antimicrobial peptides, histones, and cell-specific proteases and thereby provide a matrix to entrap and kill microbes and to induce the contact system. This review summarizes the latest research on ETs and their role in innate immunity and host innate defense. Attention is also given to mechanisms by which certain leading bacterial pathogens have evolved to avoid entrapment and killing in these specialized structures.
      datePublished:2009-05-16T00:00:00Z
      dateModified:2009-05-16T00:00:00Z
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         Mast cell
         Eosinophil
         Extracellular trap
         Innate immunity
         Bacterial infection
         Virulence factors
         Antimicrobial peptides
         DNA
         Histones
         Mitochondria
         Molecular Medicine
         Human Genetics
         Internal Medicine
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