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We are analyzing https://link.springer.com/article/10.1007/s00109-009-0451-6.

Title:
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations | Journal of Molecular Medicine
Description:
Genome-wide association scans recently identified common polymorphisms, in intron 1 of FTO and 188 kb downstream MC4R, that modulate body mass index (BMI) and associate with increased risk of obesity. Although their individual contribution to obesity phenotype is modest, their combined effects and their interactions with environmental factors remained to be evaluated in large general populations from birth to adulthood. In the present study, we analyzed independent and combined effects of the FTO rs1421085 and MC4R rs17782313 risk alleles on BMI, fat mass, prevalence and incidence of obesity and subsequent type 2 diabetes (T2D) as well as their interactions with physical activity levels and gender in two European prospective population-based cohorts of 4,762 Finnish adolescents (NFBC 1986) and 3,167 French adults (D.E.S.I.R.). Compared to participants carrying neither FTO nor MC4R risk allele (20–24% of the populations), subjects with three or four risk alleles (7–10% of the populations) had a 3-fold increased susceptibility of developing obesity during childhood. In adults, their combined effects were more modest (~1.8-fold increased risk) and associated with a 1.27% increase in fat mass (P = 0.001). Prospectively, we demonstrated that each FTO and MC4R risk allele increased obesity and T2D incidences by 24% (P = 0.02) and 21% (P = 0.02), respectively. However, the effect on T2D disappeared after adjustment for BMI. The Z-BMI and ponderal index of newborns homozygous for the rs1421085 C allele were 0.1 units (P = 0.02) and 0.27 g/cm3 (P = 0.005) higher, respectively, than in those without FTO risk allele. The MC4R rs17782313 C allele was more associated with obesity and fat mass deposition in males than in females (P = 0.003 and P = 0.03, respectively) and low physical activity accentuated the effect of the FTO polymorphism on BMI increase and obesity prevalence (P = 0.008 and P = 0.01, respectively). In European general populations, the combined effects of common polymorphisms in FTO and MC4R are therefore additive, predictive of obesity and T2D, and may be influenced by interactions with physical activity levels and gender, respectively.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

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What CMS is link.springer.com built with?

Custom-built

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Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

article, obesity, google, scholar, fto, pubmed, cas, gene, risk, mcr, mass, fat, diabetes, association, common, variants, effects, study, physical, activity, genetic, desir, genet, france, institute, health, oulu, general, body, adults, finland, analysis, european, combined, populations, bmi, med, university, doc, privacy, cookies, content, journal, marre, balkau, marjoriitta, järvelin, philippe, froguel, index,

Topics {✒️}

genome wide association dual-energy x-ray absorptiometry month download article/chapter norwegian population-based cohort professor leena peltonen-palotie case–control studies anna-liisa hartikainen �fondation de france” mc4r genetic variants full article pdf privacy choices/manage cookies molecular medicine aims philippe froguel cross-regional institute obesity-related traits french epidemiological study genetic variants common variation melanocortin-4 receptor results melanocortin-4 receptor deficiency european economic area european general populations obesity related phenotypes body fat accumulation common polymorphisms 3-fold increased susceptibility 8-fold increased risk tuija tammelin jaana laitinen arturo gonzalez-izquierdo environmental factors remained stender-petersen kl asian indian sikhs proopiomelanocortin gene expression bioelectrical impedance accuracy st-onge mp du cane road electronic supplementary material genetic analysis attributable risk percent large general populations fat mass deposition michel marre common obesity variant conditions privacy policy carrying increasing numbers article cauchi fto variants confer age-dependent penetrance dna bank management

Schema {🗺️}

WebPage:
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         headline:Combined effects of MC4R and FTO common genetic variants on obesity in European general populations
         description:Genome-wide association scans recently identified common polymorphisms, in intron 1 of FTO and 188 kb downstream MC4R, that modulate body mass index (BMI) and associate with increased risk of obesity. Although their individual contribution to obesity phenotype is modest, their combined effects and their interactions with environmental factors remained to be evaluated in large general populations from birth to adulthood. In the present study, we analyzed independent and combined effects of the FTO rs1421085 and MC4R rs17782313 risk alleles on BMI, fat mass, prevalence and incidence of obesity and subsequent type 2 diabetes (T2D) as well as their interactions with physical activity levels and gender in two European prospective population-based cohorts of 4,762 Finnish adolescents (NFBC 1986) and 3,167 French adults (D.E.S.I.R.). Compared to participants carrying neither FTO nor MC4R risk allele (20–24% of the populations), subjects with three or four risk alleles (7–10% of the populations) had a 3-fold increased susceptibility of developing obesity during childhood. In adults, their combined effects were more modest (~1.8-fold increased risk) and associated with a 1.27% increase in fat mass (P = 0.001). Prospectively, we demonstrated that each FTO and MC4R risk allele increased obesity and T2D incidences by 24% (P = 0.02) and 21% (P = 0.02), respectively. However, the effect on T2D disappeared after adjustment for BMI. The Z-BMI and ponderal index of newborns homozygous for the rs1421085 C allele were 0.1 units (P = 0.02) and 0.27 g/cm3 (P = 0.005) higher, respectively, than in those without FTO risk allele. The MC4R rs17782313 C allele was more associated with obesity and fat mass deposition in males than in females (P = 0.003 and P = 0.03, respectively) and low physical activity accentuated the effect of the FTO polymorphism on BMI increase and obesity prevalence (P = 0.008 and P = 0.01, respectively). In European general populations, the combined effects of common polymorphisms in FTO and MC4R are therefore additive, predictive of obesity and T2D, and may be influenced by interactions with physical activity levels and gender, respectively.
         datePublished:2009-03-03T00:00:00Z
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            Obesity
            SNP
            Population genetics
            Molecular Medicine
            Human Genetics
            Internal Medicine
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      headline:Combined effects of MC4R and FTO common genetic variants on obesity in European general populations
      description:Genome-wide association scans recently identified common polymorphisms, in intron 1 of FTO and 188 kb downstream MC4R, that modulate body mass index (BMI) and associate with increased risk of obesity. Although their individual contribution to obesity phenotype is modest, their combined effects and their interactions with environmental factors remained to be evaluated in large general populations from birth to adulthood. In the present study, we analyzed independent and combined effects of the FTO rs1421085 and MC4R rs17782313 risk alleles on BMI, fat mass, prevalence and incidence of obesity and subsequent type 2 diabetes (T2D) as well as their interactions with physical activity levels and gender in two European prospective population-based cohorts of 4,762 Finnish adolescents (NFBC 1986) and 3,167 French adults (D.E.S.I.R.). Compared to participants carrying neither FTO nor MC4R risk allele (20–24% of the populations), subjects with three or four risk alleles (7–10% of the populations) had a 3-fold increased susceptibility of developing obesity during childhood. In adults, their combined effects were more modest (~1.8-fold increased risk) and associated with a 1.27% increase in fat mass (P = 0.001). Prospectively, we demonstrated that each FTO and MC4R risk allele increased obesity and T2D incidences by 24% (P = 0.02) and 21% (P = 0.02), respectively. However, the effect on T2D disappeared after adjustment for BMI. The Z-BMI and ponderal index of newborns homozygous for the rs1421085 C allele were 0.1 units (P = 0.02) and 0.27 g/cm3 (P = 0.005) higher, respectively, than in those without FTO risk allele. The MC4R rs17782313 C allele was more associated with obesity and fat mass deposition in males than in females (P = 0.003 and P = 0.03, respectively) and low physical activity accentuated the effect of the FTO polymorphism on BMI increase and obesity prevalence (P = 0.008 and P = 0.01, respectively). In European general populations, the combined effects of common polymorphisms in FTO and MC4R are therefore additive, predictive of obesity and T2D, and may be influenced by interactions with physical activity levels and gender, respectively.
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      dateModified:2009-03-03T00:00:00Z
      pageStart:537
      pageEnd:546
      sameAs:https://doi.org/10.1007/s00109-009-0451-6
      keywords:
         Obesity
         SNP
         Population genetics
         Molecular Medicine
         Human Genetics
         Internal Medicine
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            name:Stéphane Cauchi
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            name:Fanny Stutzmann
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                     name:CNRS 8090—Institute of Biology, Pasteur Institute, Lille, France
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            name:Anneli Pouta
            affiliation:
                  name:University of Oulu
                  address:
                     name:Public Health Science and General Practice, University of Oulu, Oulu, Finland
                     type:PostalAddress
                  type:Organization
                  name:Imperial College London
                  address:
                     name:Epidemiology and Public Health, Imperial College London, London, UK
                     type:PostalAddress
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            type:Person
            name:Anna-Liisa Hartikainen
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                  name:University of Oulu
                  address:
                     name:Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland
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            affiliation:
                  name:INSERM U695
                  address:
                     name:INSERM U695, Paris, France
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                  name:René Diderot–Paris 7 University
                  address:
                     name:René Diderot–Paris 7 University, Paris, France
                     type:PostalAddress
                  type:Organization
                  name:Bichat Claude Bernard Hospital
                  address:
                     name:Endocrinology–Diabetology and Nutrition, Bichat Claude Bernard Hospital, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sylviane Vol
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                  name:Regional Institute for Health
                  address:
                     name:Regional Institute for Health, La Riche, France
                     type:PostalAddress
                  type:Organization
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            name:Tuija Tammelin
            affiliation:
                  name:Finnish Institute of Occupational Health
                  address:
                     name:Finnish Institute of Occupational Health, Helsinki, Finland
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            name:Jaana Laitinen
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            name:Arturo Gonzalez-Izquierdo
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            name:David Meyre
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                  name:Pasteur Institute
                  address:
                     name:CNRS 8090—Institute of Biology, Pasteur Institute, Lille, France
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            name:Beverley Balkau
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            name:Marjo-Riitta Järvelin
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