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         headline:Regulated cell death and adaptive stress responses
         description:Eukaryotic cells react to potentially dangerous perturbations of the intracellular or extracellular microenvironment by activating rapid (transcription-independent) mechanisms that attempt to restore homeostasis. If such perturbations persist, cells may still try to cope with stress by activating delayed and robust (transcription-dependent) adaptive systems, or they may actively engage in cellular suicide. This regulated form of cell death can manifest with various morphological, biochemical and immunological correlates, and constitutes an ultimate attempt of stressed cells to maintain organismal homeostasis. Here, we dissect the general organization of adaptive cellular responses to stress, their intimate connection with regulated cell death, and how the latter operates for the preservation of organismal homeostasis.
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      headline:Regulated cell death and adaptive stress responses
      description:Eukaryotic cells react to potentially dangerous perturbations of the intracellular or extracellular microenvironment by activating rapid (transcription-independent) mechanisms that attempt to restore homeostasis. If such perturbations persist, cells may still try to cope with stress by activating delayed and robust (transcription-dependent) adaptive systems, or they may actively engage in cellular suicide. This regulated form of cell death can manifest with various morphological, biochemical and immunological correlates, and constitutes an ultimate attempt of stressed cells to maintain organismal homeostasis. Here, we dissect the general organization of adaptive cellular responses to stress, their intimate connection with regulated cell death, and how the latter operates for the preservation of organismal homeostasis.
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               type:PostalAddress
            type:Organization
            name:Hopitâl Européen George Pompidou, AP-HP
            address:
               name:Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, Paris, France
               type:PostalAddress
            type:Organization
            name:Karolinska University Hospital
            address:
               name:Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
      name:U1138, INSERM, Paris, France
      name:Sorbonne Paris Cité, Université Paris Descartes/Paris V, Paris, France
      name:Université Pierre et Marie Curie/Paris VI, Paris, France
      name:Gustave Roussy Comprehensive Cancer Institute, Villejuif, France
      name:Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
      name:U1138, INSERM, Paris, France
      name:Sorbonne Paris Cité, Université Paris Descartes/Paris V, Paris, France
      name:Université Pierre et Marie Curie/Paris VI, Paris, France
      name:Gustave Roussy Comprehensive Cancer Institute, Villejuif, France
      name:Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
      name:U1138, INSERM, Paris, France
      name:Sorbonne Paris Cité, Université Paris Descartes/Paris V, Paris, France
      name:Université Pierre et Marie Curie/Paris VI, Paris, France
      name:Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France
      name:Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
      name:U1138, INSERM, Paris, France
      name:Sorbonne Paris Cité, Université Paris Descartes/Paris V, Paris, France
      name:Université Pierre et Marie Curie/Paris VI, Paris, France
      name:Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France
      name:Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, Paris, France
      name:Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden
WebPageElement:
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