We are analyzing https://link.springer.com/article/10.1007/s00018-012-0935-3.

Title:
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors | Cellular and Molecular Life Sciences
Description:
ZEB1 and ZEB2, which are members of the ZEB family of transcription factors, play a pivotal role in the development of the vertebrate embryo. However, recent evidence shows that both proteins can also drive the process of epithelial-mesenchymal transition during malignant cancer progression. The understanding of how both ZEBs act as transcription factors opens up new possibilities for future treatment of advanced carcinomas. This review gives insight into the molecular mechanisms that form the basis of the multitude of cellular processes controlled by both ZEB factors. By using an evolutionary approach, we analyzed how the specific organization of the different domains and regulatory sites in ZEB1 and ZEB2 came into existence. On the basis of this analysis, a detailed overview is provided of the different cofactors and post-translational mechanisms that are associated with ZEB protein functionality.
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Keywords {🔍}

article, google, scholar, pubmed, cas, cell, zeb, biol, protein, transcription, cancer, mol, van, epithelial, transition, gene, zinc, ctbp, regulation, development, cells, expression, molecular, factors, berx, sci, dev, epithelialmesenchymal, factor, finger, deltaef, mesenchymal, research, snail, sip, natl, huylebroeck, binding, genes, kondoh, repression, oncogene, corepressor, roy, proteins, transcriptional, proc, acad, res, embo,

Topics {✒️}

tgf-beta-induced epithelial-mesenchymal transition tgf-beta-induced collagen expression neural crest cells zinc-finger-homeodomain protein areb6 tgf-beta/bmp signaling pathway tgf-beta1-mediated growth suppression e2-box-mediated gene activation beta-catenin/tcf4 complex induces month download article/chapter basic helix-loop-helix proteins tgf-beta induced transdifferentiation adult t-cell leukemia/lymphoma tgf-beta-induced epithelial snail1-induced epithelial-mesenchymal transition immunoglobulin heavy-chain enhancer zinc finger/homeodomain repressor paco hulpiau zeb/mir-200 feedback loop repetitive zinc-binding domains tgf-beta signaling e-box-binding repressor author information authors t24-ras mediated transformation zeb transcription factors protein–protein interactions mediated geert berx zinc finger protein tmprss2/erg promotes epithelial van grunsven la regulatory sites induce epithelial-mesenchymal transition transcription factors opens transcription factors positively double-negative feedback loop sip1/zeb2 induces emt epithelial cell–cell junctions author correspondence developmental gene activation inhibits gene transcription dna damage-induced apoptosis biomedical molecular biology zeb represses transcription zeb1 represses e-cadherin mammary epithelial cells homeodomain transcription factor full article pdf evolutionary functional analysis breast cancer cells smad-interacting protein 1 smad-interacting protein-1

Questions {❓}

Berx G, Raspé E, Christofori G, Thiery JP, Sleeman JP (2007) Pre-EMTing metastasis?
Brabletz S, Brabletz T (2010) The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?
Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

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      headline:Evolutionary functional analysis and molecular regulation of the ZEB transcription factors
      description:ZEB1 and ZEB2, which are members of the ZEB family of transcription factors, play a pivotal role in the development of the vertebrate embryo. However, recent evidence shows that both proteins can also drive the process of epithelial-mesenchymal transition during malignant cancer progression. The understanding of how both ZEBs act as transcription factors opens up new possibilities for future treatment of advanced carcinomas. This review gives insight into the molecular mechanisms that form the basis of the multitude of cellular processes controlled by both ZEB factors. By using an evolutionary approach, we analyzed how the specific organization of the different domains and regulatory sites in ZEB1 and ZEB2 came into existence. On the basis of this analysis, a detailed overview is provided of the different cofactors and post-translational mechanisms that are associated with ZEB protein functionality.
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         Neural crest cells
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         Cell Biology
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         general
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         Biochemistry
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