We are analyzing https://link.springer.com/article/10.1007/s00018-011-0834-z.

Title:
Inflammation and repeated infections in CGD: two sides of a coin | Cellular and Molecular Life Sciences
Description:
Chronic granulomatous disease (CGD) is an uncommon congenital immunodeficiency seen approximately in 1 of 250,000 individuals. It is caused by a profound defect in a burst of oxygen consumption that normally accompanies phagocytosis in all myeloid cells (neutrophils, eosinophils, monocytes, and macrophages). This “respiratory burst” involves the catalytic conversion of molecular oxygen to the oxygen free-radical superoxide, which in turn gives rise to hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. These oxygen derivatives play a critical role in the killing of pathogenic bacteria and fungi. As a result of the failure to activate the respiratory burst in their phagocytes, the majority of CGD patients suffer from severe recurrent infections and rather unexplained prolonged inflammatory reactions that may result in granulomatous lesions. Both may cause severe organ dysfunction depending on the tissues involved. Preventive measures as well as rapid (invasive) diagnostic procedures are required to successfully treat CGD. Hematopoietic stem cell transplantation may be a serious option in some of the patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

cgd, cells, article, google, scholar, pubmed, cas, ido, cell, nadph, disease, patients, oxidase, activity, chronic, granulomatous, inflammation, inflammatory, mice, macrophages, responses, immune, pphox, activation, production, lkynurenine, van, infection, regulatory, tryptophan, human, immunol, ros, tissue, oxygen, neutrophils, role, aspergillus, defective, response, induction, pathogens, innate, lung, tregs, species, granuloma, romani, kuijpers, superoxide,

Topics {✒️}

autosomal-dominant hyper-ige syndrome cd4 + cd25 + antigen-specific regulatory vitro-expanded antigen-specific regulatory article download pdf ido-mediated l-tryptophan metabolism cd4 + cd25 + foxp3 + chronic granulomatous disease catalase-deficient aspergillus nidulans augmented nf-κb activation gp 91phox-deficient patients th2 cell-signaling pathways hyper-ige syndrome l-kynurenine suppletion restores natural l-kynurenine distal oxygen free-radical superoxide amino acid l-tryptophan full size image constitutively express il-17r inadequate anti-microbial defense increased nf-κb activation ido converts l-tryptophan zymosan-induced lung inflammation inadequate anti-microbial response ifn-γ amplifies il-6 membrane-bound tgf-β [51] ido product l-kynurenine ido-generated l-kynurenine ifn-γ-exposed monocytes il-17-mediated immune pathway drive chronic inflammation reactive oxygen species van der loos van der poll redox-mediated signaling tight junction proteins privacy choices/manage cookies exaggerated inflammatory responses gp91phox-negative dendritic cells promote chronic inflammation nadph oxidase-deficient p47phox-mutated background innate il-17-producing cells inflammatory immune responses anti-inflammatory agent activate tgf-β exaggerated inflammatory response regulatory pathways exist develop autoimmune diseases tryptophan/kynurenine metabolism anti-inflammatory macrophages

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Inflammation and repeated infections in CGD: two sides of a coin
         description:Chronic granulomatous disease (CGD) is an uncommon congenital immunodeficiency seen approximately in 1 of 250,000 individuals. It is caused by a profound defect in a burst of oxygen consumption that normally accompanies phagocytosis in all myeloid cells (neutrophils, eosinophils, monocytes, and macrophages). This “respiratory burst” involves the catalytic conversion of molecular oxygen to the oxygen free-radical superoxide, which in turn gives rise to hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. These oxygen derivatives play a critical role in the killing of pathogenic bacteria and fungi. As a result of the failure to activate the respiratory burst in their phagocytes, the majority of CGD patients suffer from severe recurrent infections and rather unexplained prolonged inflammatory reactions that may result in granulomatous lesions. Both may cause severe organ dysfunction depending on the tissues involved. Preventive measures as well as rapid (invasive) diagnostic procedures are required to successfully treat CGD. Hematopoietic stem cell transplantation may be a serious option in some of the patients.
         datePublished:2011-11-15T00:00:00Z
         dateModified:2011-11-15T00:00:00Z
         pageStart:7
         pageEnd:15
         license:https://creativecommons.org/licenses/by-nc/2.0
         sameAs:https://doi.org/10.1007/s00018-011-0834-z
         keywords:
            Infection
            Inflammation
            Granuloma
            NADPH oxidase
            IDO
            Tryptophan
            Kynurenine
            IL-17
            Tregs
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-011-0834-z/MediaObjects/18_2011_834_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-011-0834-z/MediaObjects/18_2011_834_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-011-0834-z/MediaObjects/18_2011_834_Fig3_HTML.jpg
         isPartOf:
            name:Cellular and Molecular Life Sciences
            issn:
               1420-9071
               1420-682X
            volumeNumber:69
            type:
               Periodical
               PublicationVolume
         publisher:
            name:SP Birkhäuser Verlag Basel
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Taco Kuijpers
               affiliation:
                     name:University of Amsterdam
                     address:
                        name:Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:University of Amsterdam
                     address:
                        name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Rene Lutter
               affiliation:
                     name:University of Amsterdam
                     address:
                        name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:University of Amsterdam
                     address:
                        name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Inflammation and repeated infections in CGD: two sides of a coin
      description:Chronic granulomatous disease (CGD) is an uncommon congenital immunodeficiency seen approximately in 1 of 250,000 individuals. It is caused by a profound defect in a burst of oxygen consumption that normally accompanies phagocytosis in all myeloid cells (neutrophils, eosinophils, monocytes, and macrophages). This “respiratory burst” involves the catalytic conversion of molecular oxygen to the oxygen free-radical superoxide, which in turn gives rise to hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. These oxygen derivatives play a critical role in the killing of pathogenic bacteria and fungi. As a result of the failure to activate the respiratory burst in their phagocytes, the majority of CGD patients suffer from severe recurrent infections and rather unexplained prolonged inflammatory reactions that may result in granulomatous lesions. Both may cause severe organ dysfunction depending on the tissues involved. Preventive measures as well as rapid (invasive) diagnostic procedures are required to successfully treat CGD. Hematopoietic stem cell transplantation may be a serious option in some of the patients.
      datePublished:2011-11-15T00:00:00Z
      dateModified:2011-11-15T00:00:00Z
      pageStart:7
      pageEnd:15
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s00018-011-0834-z
      keywords:
         Infection
         Inflammation
         Granuloma
         NADPH oxidase
         IDO
         Tryptophan
         Kynurenine
         IL-17
         Tregs
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-011-0834-z/MediaObjects/18_2011_834_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-011-0834-z/MediaObjects/18_2011_834_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-011-0834-z/MediaObjects/18_2011_834_Fig3_HTML.jpg
      isPartOf:
         name:Cellular and Molecular Life Sciences
         issn:
            1420-9071
            1420-682X
         volumeNumber:69
         type:
            Periodical
            PublicationVolume
      publisher:
         name:SP Birkhäuser Verlag Basel
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Taco Kuijpers
            affiliation:
                  name:University of Amsterdam
                  address:
                     name:Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:University of Amsterdam
                  address:
                     name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Rene Lutter
            affiliation:
                  name:University of Amsterdam
                  address:
                     name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:University of Amsterdam
                  address:
                     name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences
      issn:
         1420-9071
         1420-682X
      volumeNumber:69
Organization:
      name:SP Birkhäuser Verlag Basel
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Amsterdam
      address:
         name:Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
         type:PostalAddress
      name:University of Amsterdam
      address:
         name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
         type:PostalAddress
      name:University of Amsterdam
      address:
         name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
         type:PostalAddress
      name:University of Amsterdam
      address:
         name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Taco Kuijpers
      affiliation:
            name:University of Amsterdam
            address:
               name:Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:University of Amsterdam
            address:
               name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Rene Lutter
      affiliation:
            name:University of Amsterdam
            address:
               name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:University of Amsterdam
            address:
               name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
      name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
      name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
      name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands

External Links {🔗}(171)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.7s.

LINK . SPRINGER . COM {}