We are analyzing https://link.springer.com/article/10.1007/s00018-011-0783-6.

Title:
Advances in tenascin-C biology | Cellular and Molecular Life Sciences
Description:
Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.
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Keywords {🔍}

tenascinc, google, scholar, expression, pubmed, cas, article, cells, cell, tumor, cancer, tissue, cardiac, matrix, mice, human, injury, vascular, induced, remodeling, disease, patients, smc, heart, fibronectin, data, gbm, levels, growth, shown, null, breast, biol, res, role, ecm, angiogenesis, mmp, extracellular, found, arteries, atherosclerosis, plaque, arterial, stem, protein, tenascin, studies, rat, proliferation,

Topics {✒️}

phosphacan/receptor protein-tyrosine phosphatase-zeta/beta habu-snake venom-induced glomerulonephritis immuno-compromised nod/scid mice antibody-based tenascin-c-targeting strategies benoit langlois & gertraud orend alpha-smooth muscle actin integrin alphavbeta3/pdgfr-beta complex high-resolution time-lapse imaging tenascin-c-deficient mefs comparing tenascin-c-mmp feedback loops tenascin-c-enriched matrix channels tenascin-c-enriched tubular structures snake venom-induced glomerulonephritis article download pdf hgf/scatter factor receptor mcf-10a acini deposited alpha-particle emitting 211at label-free lc-ms double-strand rna directed bone marrow-derived cells anti-fniiid sip antibodies cross-linking αvβ3 integrins s-adenosylmethionine decarboxylase full-length hexameric molecule canonical wnt-flt1 pathway positive feed-forward loop post-ischemic heart resulting t-zone reticular networks mediate post-translational control perform kaplan–meier analyses confer tumor-initiating properties c-terminal domains critical von willebrand factor blocks cell-cycle progression degrade full-length tenascin tenascin-c-regulated target gene n-myc gene amplification providing guiding cues stem cell homeostasis fibrin-rich blood clot pro-angiogenic factors driving powerful anti-cancer target rbpjk/notch2 dependent transactivation pro-fibrotic growth factors /erk-mapk-dependent amoeboid traditional anti-cancer drugs tumor-derived endothelial cells regulating c-met function post-translational modification rbpjkappa-induced target gene

Questions {❓}

These data raise a number of intriguing questions such as: what induces tenascin-C expression upon cardiac injury?

Schema {🗺️}

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         headline:Advances in tenascin-C biology
         description:Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.
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      headline:Advances in tenascin-C biology
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         Tumor metastasis
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         general
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         Biochemistry
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            address:
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      name:Kennedy Institute of Rheumatology Division, Faculty of Medicine, NDORMS, Oxford University, Hammersmith, London, UK
      name:Institut National de la Santé et de la Recherche Médicale U682, Faculté de Médicine, Université Strasbourg, UMR-S682, Strasbourg, CHRU Strasbourg, Service biologie moléculaire, Strasbourg, France
      name:Institut National de la Santé et de la Recherche Médicale U682, Faculté de Médicine, Université Strasbourg, UMR-S682, Strasbourg, CHRU Strasbourg, Service biologie moléculaire, Strasbourg, France
      name:Institut National de la Santé et de la Recherche Médicale U682, Faculté de Médicine, Université Strasbourg, UMR-S682, Strasbourg, CHRU Strasbourg, Service biologie moléculaire, Strasbourg, France

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