We are analyzing https://link.springer.com/article/10.1007/s00018-010-0394-7.

Title:
MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma | Cellular and Molecular Life Sciences
Description:
Since bone morphogenetic proteins (BMPs) play an important role in melanoma progression, we aimed to determine the molecular mechanisms leading to overexpression of BMP4 in melanoma cells compared to normal melanocytes. With our experimental approach we revealed that loss of expression of a microRNA represents the starting point for a signaling cascade finally resulting in overexpression of BMP4 in melanoma cells. In detail, strongly reduced expression of the microRNA miR-196a in melanoma cells compared to healthy melanocytes leads to enhanced HOX-B7 mRNA and protein levels, which subsequently raise Ets-1 activity by inducing basic fibroblast growth factor (bFGF). Ets-1 finally accounts for induction of BMP4 expression. We were furthermore able to demonstrate that bFGF-mediated induction of migration is achieved via activation of BMP4, thus determining BMP4 as major modulator of migration in melanoma. In summary, our study provides insights into the early steps of melanoma progression and might thereby harbor therapeutic relevance.
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Keywords {🔍}

cas, pubmed, google, scholar, article, melanoma, cell, growth, expression, bone, bmp, cancer, protein, morphogenetic, cells, factor, fibroblast, bfgf, microrna, bosserhoff, human, hoxb, malignant, proteins, gene, sci, fig, rothhammer, progression, signaling, mrna, basic, res, mol, genes, mueller, melanocytes, migration, proliferation, mirnas, moesmesmjpeg, jpeg, privacy, cookies, content, braig, levels, ets, biol, oncogene,

Topics {✒️}

tanja rothhammer & anja-katrin bosserhoff month download article/chapter fibroblast growth factor fibroblast growth factor-2 urokinase-type plasminogen activator confers epithelial-mesenchymal transition franz-josef-strauss-allee 11 ski/sno homolog protein enhanced hox-b7 mrna m7gppp-capped target mrnas stimulates tumor growth bone morphogenetic proteins anja-katrin bosserhoff autocrine growth factor bone morphogenetic protein-2 vascular endothelial cells ets-1 regulates angiogenesis bone morphogenic proteins full article pdf ets-1 transcription factor bfgf expressing adenovirus lewis-russell jm privacy choices/manage cookies mammalian microrna targets bmp6-induced modulation microrna mir-196a melanocyte growth factors melanocyte growth medium melanoma cells compared strongly reduced expression increases cell proliferation polymerase chain reaction mammalian homeobox genes human malignant melanomas vertebrate microrna expression microrna expression signature distinctive microrna signature microrna-directed cleavage microrna sequence database cell lines derived overexpressed hox genes bfgf-mediated induction promote cell invasion hox gene regulation martelli mf jones-rhoades mw ovarian cancer cells human melanoma progression human chondrosarcoma cells tumor growth

Questions {❓}

Hsu MY, Rovinsky S, Penmatcha S, Herlyn M, Muirhead D (2005) Bone morphogenetic proteins in melanoma: angel or devil?
Pillai RS, Bhattacharyya SN, Filipowicz W (2007) Repression of protein synthesis by miRNAs: how many mechanisms?

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      description:Since bone morphogenetic proteins (BMPs) play an important role in melanoma progression, we aimed to determine the molecular mechanisms leading to overexpression of BMP4 in melanoma cells compared to normal melanocytes. With our experimental approach we revealed that loss of expression of a microRNA represents the starting point for a signaling cascade finally resulting in overexpression of BMP4 in melanoma cells. In detail, strongly reduced expression of the microRNA miR-196a in melanoma cells compared to healthy melanocytes leads to enhanced HOX-B7 mRNA and protein levels, which subsequently raise Ets-1 activity by inducing basic fibroblast growth factor (bFGF). Ets-1 finally accounts for induction of BMP4 expression. We were furthermore able to demonstrate that bFGF-mediated induction of migration is achieved via activation of BMP4, thus determining BMP4 as major modulator of migration in melanoma. In summary, our study provides insights into the early steps of melanoma progression and might thereby harbor therapeutic relevance.
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         general
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         Biochemistry
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