We are analyzing https://link.springer.com/article/10.1007/s00018-009-0027-1.

Title:
The annexins: spatial and temporal coordination of signaling events during cellular stress | Cellular and Molecular Life Sciences
Description:
Annexins are a family of structurally related, Ca2+-sensitive proteins that bind to negatively charged phospholipids and establish specific interactions with other lipids and lipid microdomains. They are present in all eukaryotic cells and share a common folding motif, the “annexin core”, which incorporates Ca2+- and membrane-binding sites. Annexins participate in a variety of intracellular processes, ranging from the regulation of membrane dynamics to cell migration, proliferation, and apoptosis. Here we focus on the role of annexins in cellular signaling during stress. A chronic stress response triggers the activation of different intracellular pathways, resulting in profound changes in Ca2+ and pH homeostasis and the production of lipid second messengers. We review the latest data on how these changes are sensed by the annexins, which have the ability to simultaneously interact with specific lipid and protein moieties at the plasma membrane, contributing to stress adaptation via regulation of various signaling pathways.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, pubmed, cas, annexin, cell, biol, membrane, annexins, gerke, mol, chem, protein, cells, calcium, biochem, lipid, binding, draeger, res, kinase, babiychuk, moss, human, biochemistry, signaling, monastyrskaya, biophys, intracellular, physiol, rescher, regulates, stress, association, domain, complex, article, dynamics, structure, sci, proteins, regulation, membranes, actin, function, analysis, cellular, plasma, signalling, muscle,

Topics {✒️}

e-cadherin-based adherens junctions 12-o-tetradecanoylphorbol-13-acetate-induced activation s100-related light chain month download article/chapter ras/extracellular signal-regulated kinase calcium-activated chloride conductance [3h]-da release evoked annexin ii-s100a10 complex store-operated ca2+ entry mediates sarcolemmal wound-healing membrane-bound annexin ii store-mediated calcium entry store-operated calcium channels balb/3t3 fibroblasts reflecting camp/pka/cna acute hypoxic-ischemic injury anx-a1−/− cell line mitogen-activated protein kinase site-directed spin labeling actin-based macropinocytic rocketing calcium-dependent proapoptotic effect egf-dependent calcium influx signal transduction calcium-driven conformational switch annexin a6-induced alterations atp-dependent membrane localization annexin a2/s100a10 heterotetramer acidic ph-induced folding peroxide-induced ca2+ influx cholesterol-stabilized membrane domains s100-annexin complexes-biology annexin vi-mediated loss membrane-binding protein annexin smooth-muscle plasma membrane htrpc1-forming ca2+ channels cell-surface attachment van der vusse s100a10-annexin 2 complex annexin 2-s100a10 complex ca2+-independent store lipid-mediated cell regulation linking ca2+ signalling van rossum db de luca lm plasma membrane repair privacy choices/manage cookies peripheral membrane protein capacitative calcium entry activated protein kinase related subjects

Questions {❓}

Babiychuk EB, Babiychuk VS, Danilova VM, Tregubov VS, Sagach VF, Draeger A (2002) Stress fibres-a Ca2+-independent store for annexins?
Gamper N, Shapiro MS (2007) Target-specific PIP(2) signalling: how might it work?
Van Blitterswijk WJ, van der Luit AH, Veldman RJ, Verheij M, Borst J (2003) Ceramide: second messenger or modulator of membrane structure and dynamics?

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