We are analyzing https://link.springer.com/article/10.1007/s00018-008-8252-6.

Title:
Diverse molecular functions of Hu proteins | Cellular and Molecular Life Sciences
Description:
Hu proteins are RNA-binding proteins involved in diverse biological processes. The neuronal members of the Hu family, HuB, HuC, and HuD play important roles in neuronal differentiation and plasticity, while the ubiquitously expressed family member, HuR, has numerous functions mostly related to cellular stress response. The pivotal roles of Hu proteins are dictated by their molecular functions affecting a large number of target genes. Hu proteins affect many post-transcriptional aspects of RNA metabolism, from splicing to translation. In this communication, we will focus on these molecular events and review our current understanding of how Hu proteins mediate them. In particular, emphasis will be put on the nuclear functions of these proteins, which were recently discovered. Three examples including calcitonin/calcitonin gene-related peptide, neurofibromatosis type 1, and Ikaros will be discussed in detail. In addition, an intriguing theme of antagonism between Hu proteins and other AU-rich sequence binding proteins will be discussed.
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Keywords {🔍}

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Topics {✒️}

rna-binding proteins involved month download article/chapter hu proteins affect hu proteins mediate rna molecular biology diverse molecular functions privacy choices/manage cookies related subjects full article pdf molecular functions affecting hu proteins diverse biological processes author correspondence cellular stress response european economic area scope submit manuscript post-transcriptional aspects tumor stress survival suppressing mtorc1 activity huwe1 ubiquitin ligase nervous system development conditions privacy policy rna metabolism check access instant access accepting optional cookies article cellular journal finder publish proteins 1007/s00018-008-8252-6 keywords article log function pivotal roles life sci hu family lou center molecular events article cite information article hinman privacy policy personal data books a numerous functions nuclear functions optional cookies manage preferences related splicing translation

Schema {🗺️}

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         headline:Diverse molecular functions of Hu proteins
         description:Hu proteins are RNA-binding proteins involved in diverse biological processes. The neuronal members of the Hu family, HuB, HuC, and HuD play important roles in neuronal differentiation and plasticity, while the ubiquitously expressed family member, HuR, has numerous functions mostly related to cellular stress response. The pivotal roles of Hu proteins are dictated by their molecular functions affecting a large number of target genes. Hu proteins affect many post-transcriptional aspects of RNA metabolism, from splicing to translation. In this communication, we will focus on these molecular events and review our current understanding of how Hu proteins mediate them. In particular, emphasis will be put on the nuclear functions of these proteins, which were recently discovered. Three examples including calcitonin/calcitonin gene-related peptide, neurofibromatosis type 1, and Ikaros will be discussed in detail. In addition, an intriguing theme of antagonism between Hu proteins and other AU-rich sequence binding proteins will be discussed.
         datePublished:2008-06-26T00:00:00Z
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            translation
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            splicing
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            Biomedicine
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            Biochemistry
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      headline:Diverse molecular functions of Hu proteins
      description:Hu proteins are RNA-binding proteins involved in diverse biological processes. The neuronal members of the Hu family, HuB, HuC, and HuD play important roles in neuronal differentiation and plasticity, while the ubiquitously expressed family member, HuR, has numerous functions mostly related to cellular stress response. The pivotal roles of Hu proteins are dictated by their molecular functions affecting a large number of target genes. Hu proteins affect many post-transcriptional aspects of RNA metabolism, from splicing to translation. In this communication, we will focus on these molecular events and review our current understanding of how Hu proteins mediate them. In particular, emphasis will be put on the nuclear functions of these proteins, which were recently discovered. Three examples including calcitonin/calcitonin gene-related peptide, neurofibromatosis type 1, and Ikaros will be discussed in detail. In addition, an intriguing theme of antagonism between Hu proteins and other AU-rich sequence binding proteins will be discussed.
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      dateModified:2008-06-26T00:00:00Z
      pageStart:3168
      pageEnd:3181
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         Hu proteins
         mRNA stability
         translation
         polyadenylation
         splicing
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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