We are analyzing https://link.springer.com/article/10.1007/s00018-008-8094-2.

Title:
Role of Nef in primate lentiviral immunopathogenesis | Cellular and Molecular Life Sciences
Description:
More than a decade ago it was established that intact nef genes are critical for efficient viral persistence and greatly accelerate disease progression in SIVmac-infected rhesus macaques and in HIV-1-infected humans. Subsequent studies established a striking number of Nef functions that evidently contribute to the maintenance of high viral loads associated with the development of immunodeficiency in the ‘evolutionary-recent’ human and the experimental macaque hosts. Recent data show that many Nef activities are conserved across different lineages of HIV and SIV. However, some differences also exist. For example, Nef alleles from most SIVs that do not cause disease in their natural monkey hosts, but not those of HIV-1 and its simian precursors, down-modulate TCR-CD3 to suppress T cell activation and programmed death. This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans.
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Keywords {🔍}

article, nef, access, hiv, privacy, cookies, content, data, information, publish, search, primate, kirchhoff, schindler, open, author, log, journal, research, life, role, lentiviral, april, specht, viral, siv, products, discover, springer, function, optional, personal, parties, policy, find, track, cellular, molecular, sciences, immunopathogenesis, published, number, cite, arhel, münch, explore, established, persistence, disease, rhesus,

Topics {✒️}

sivmac-infected rhesus macaques species-specific host factors primate lentiviral immunopathogenesis hiv nef-mediated cd4 efficient viral persistence month download article/chapter experimental macaque hosts related subjects high viral loads privacy choices/manage cookies author correspondence full article pdf hiv-1-infected humans intact nef genes check access instant access european economic area scope submit manuscript natural monkey hosts modulate tcr-cd3 high virulence serinc5 downregulation activity heinrich pette institut specific nef function recent data show conditions privacy policy �evolutionary-recent’ human accepting optional cookies subsequent studies established immunodeficiency article cellular journal finder publish siv infection article log gene products article number 2621 1007/s00018-008-8094-2 keywords article cite personal data privacy policy life sci article kirchhoff books a nef functions nef activities nef alleles hiv hiv-1 information optional cookies

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         headline:Role of Nef in primate lentiviral immunopathogenesis
         description:More than a decade ago it was established that intact nef genes are critical for efficient viral persistence and greatly accelerate disease progression in SIVmac-infected rhesus macaques and in HIV-1-infected humans. Subsequent studies established a striking number of Nef functions that evidently contribute to the maintenance of high viral loads associated with the development of immunodeficiency in the ‘evolutionary-recent’ human and the experimental macaque hosts. Recent data show that many Nef activities are conserved across different lineages of HIV and SIV. However, some differences also exist. For example, Nef alleles from most SIVs that do not cause disease in their natural monkey hosts, but not those of HIV-1 and its simian precursors, down-modulate TCR-CD3 to suppress T cell activation and programmed death. This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans.
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            HIV
            SIV
            pathogenesis
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            primate lentiviruses
            immunological synapse
            viral persistence
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
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      headline:Role of Nef in primate lentiviral immunopathogenesis
      description:More than a decade ago it was established that intact nef genes are critical for efficient viral persistence and greatly accelerate disease progression in SIVmac-infected rhesus macaques and in HIV-1-infected humans. Subsequent studies established a striking number of Nef functions that evidently contribute to the maintenance of high viral loads associated with the development of immunodeficiency in the ‘evolutionary-recent’ human and the experimental macaque hosts. Recent data show that many Nef activities are conserved across different lineages of HIV and SIV. However, some differences also exist. For example, Nef alleles from most SIVs that do not cause disease in their natural monkey hosts, but not those of HIV-1 and its simian precursors, down-modulate TCR-CD3 to suppress T cell activation and programmed death. This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans.
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         HIV
         SIV
         pathogenesis
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         primate lentiviruses
         immunological synapse
         viral persistence
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         Biochemistry
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