We are analyzing https://link.springer.com/article/10.1007/s00018-006-6167-7.

Title:
Lipid flippases and their biological functions | Cellular and Molecular Life Sciences
Description:
The typically distinct phospholipid composition of the two leaflets of a membrane bilayer is generated and maintained by bi-directional transport (flip-flop) of lipids between the leaflets. Specific membrane proteins, termed lipid flippases, play an essential role in this transport process. Energy-independent flippases allow common phospholipids to equilibrate rapidly between the two monolayers and also play a role in the biosynthesis of a variety of glycoconjugates such as glycosphingolipids, N-glycoproteins, and glycosylphosphatidylinositol (GPI)-anchored proteins. ATP-dependent flippases, including members of a conserved subfamily of P-type ATPases and ATP-binding cassette transporters, mediate the net transfer of specific phospholipids to one leaflet of a membrane and are involved in the creation and maintenance of transbilayer lipid asymmetry of membranes such as the plasma membrane of eukaryotes. Energy-dependent flippases also play a role in the biosynthesis of glycoconjugates such as bacterial lipopolysaccharide. This review summarizes recent progress on the identification and characterization of the various flippases and the demonstration of their biological functions.
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Keywords {🔍}

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Topics {✒️}

p-type atpases lipid flip-flop transbilayer lipid asymmetry specific membrane proteins month download article/chapter atp-binding cassette transporters flip-flop termed lipid flippases n-glycoproteins privacy choices/manage cookies membrane bilayer plasma membrane full article pdf biology/biophysics atp-dependent flippases lipid flippases check access instant access membrane european economic area scope submit manuscript related subjects weill medical college energy-independent flippases energy-dependent flippases conditions privacy policy author correspondence bi-directional transport specific phospholipids lipid bilayer anchored proteins biological functions accepting optional cookies common phospholipids main content log lipids humboldt university berlin journal finder publish article cellular 1007/s00018-006-6167-7 keywords membranes life sci privacy policy personal data article log books a optional cookies article cite article pomorski information

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         headline:Lipid flippases and their biological functions
         description:The typically distinct phospholipid composition of the two leaflets of a membrane bilayer is generated and maintained by bi-directional transport (flip-flop) of lipids between the leaflets. Specific membrane proteins, termed lipid flippases, play an essential role in this transport process. Energy-independent flippases allow common phospholipids to equilibrate rapidly between the two monolayers and also play a role in the biosynthesis of a variety of glycoconjugates such as glycosphingolipids, N-glycoproteins, and glycosylphosphatidylinositol (GPI)-anchored proteins. ATP-dependent flippases, including members of a conserved subfamily of P-type ATPases and ATP-binding cassette transporters, mediate the net transfer of specific phospholipids to one leaflet of a membrane and are involved in the creation and maintenance of transbilayer lipid asymmetry of membranes such as the plasma membrane of eukaryotes. Energy-dependent flippases also play a role in the biosynthesis of glycoconjugates such as bacterial lipopolysaccharide. This review summarizes recent progress on the identification and characterization of the various flippases and the demonstration of their biological functions.
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            Membrane assembly
            membrane asymmetry
            lipid flip-flop
            N-glycosylation
            ABC transporter
            P-type ATPase
            scramblase
            vesicle budding
            Cell Biology
            Biomedicine
            general
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            Biochemistry
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      pageEnd:2921
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         Membrane assembly
         membrane asymmetry
         lipid flip-flop
         N-glycosylation
         ABC transporter
         P-type ATPase
         scramblase
         vesicle budding
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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