We are analyzing https://link.springer.com/article/10.1007/s00018-005-5097-0.

Title:
Spectrin and calpain: a ‘target’ and a ‘sniper’ in the pathology of neuronal cells | Cellular and Molecular Life Sciences
Description:
It is well documented that activation of calpain, a calcium-sensitive cysteine protease, marks the pathology of naturally and experimentally occuring neurodegenerative conditions. Calpain-mediated proteolysis of major membrane-skeletal protein, αII-spectrin, results in the appearance of two unique and highly stable breakdown products, which is an early event in neural cell pathology. This review focuses on spectrin degradation by calpain within neurons induced by diverse conditions, emphasizing a current picture of multi-pattern neuronal death and a recent success in the development of spectrin-based biomarkers. The issue is presented in the context of the major structural and functional properties of the two proteins.
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article, calpain, privacy, cookies, content, spectrin, sikorski, access, information, publish, search, pathology, data, log, journal, research, molecular, life, neuronal, czogalla, conditions, proteolysis, products, neurodegeneration, discover, author, wrocław, springer, optional, personal, parties, policy, find, track, cellular, sciences, cmls, target, sniper, cells, review, published, june, cite, explore, neurodegenerative, major, cell, degradation, issue,

Topics {✒️}

calcium-sensitive cysteine protease month download article/chapter multi-pattern neuronal death major membrane-skeletal protein calpain-mediated proteolysis privacy choices/manage cookies full article pdf related subjects spectrin-based biomarkers european economic area scope submit manuscript age-dependent ataxia potential therapeutic modulators αii spectrin mutation conditions privacy policy accepting optional cookies article cellular spectrin degradation journal finder publish neurodegeneration caused check access instant access neural cell pathology article log neuronal cells molecular biology life sci author correspondence αii-spectrin privacy policy personal data article cite books a article czogalla optional cookies manage preferences review focuses diverse conditions major structural subscription content similar content data protection essential cookies cookies skip issue institution subscribe journal publish usage analysis social media varying standards

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