We are analyzing https://link.springer.com/article/10.1007/s00018-005-4527-3.

Title:
Surface exposure of phosphatidylserine in pathological cells | Cellular and Molecular Life Sciences
Description:
The asymmetric phospholipid distribution in plasma membranes is normally maintained by energy-dependent lipid transporters that translocate different phospholipids from one monolayer to the other against their respective concentration gradients. When cells are activated, or enter apoptosis, lipid asymmetry can be perturbed by other lipid transporters (scramblases) that shuttle phospholipids non-specifically between the two monolayers. This exposes phosphatidylserine (PS) at the cells’ outer surface. Since PS promotes blood coagulation, defective scramblase activity upon platelet stimulation causes a bleeding disorder (Scott syndrome). PS exposure also plays a pivotal role in the recognition and removal of apoptotic cells via a PS-recognizing receptor on phagocytic cells. Furthermore, expression of PS at the cell surface can occur in a wide variety of disorders. This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter energy-dependent lipid transporters defective scramblase activity membrane asymmetry privacy choices/manage cookies related subjects cells’ outer surface full article pdf lipid asymmetry scott syndrome surface exposure european economic area scope submit manuscript respective concentration gradients enter apoptosis promote thromboembolic complications check access instant access author correspondence conditions privacy policy ps-recognizing receptor cell surface accepting optional cookies asymmetric phospholipid distribution main content log article cellular lipid transporters journal finder publish shuttle phospholipids apoptotic cell removal life sci review aims lipid bilayer article log ps exposure privacy policy personal data article cite books a article zwaal phospholipids pathological conditions optional cookies pathological cells manage preferences apoptotic cells phospholipid distribution information exposes phosphatidylserine data protection

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         headline:Surface exposure of phosphatidylserine in pathological cells
         description:The asymmetric phospholipid distribution in plasma membranes is normally maintained by energy-dependent lipid transporters that translocate different phospholipids from one monolayer to the other against their respective concentration gradients. When cells are activated, or enter apoptosis, lipid asymmetry can be perturbed by other lipid transporters (scramblases) that shuttle phospholipids non-specifically between the two monolayers. This exposes phosphatidylserine (PS) at the cells’ outer surface. Since PS promotes blood coagulation, defective scramblase activity upon platelet stimulation causes a bleeding disorder (Scott syndrome). PS exposure also plays a pivotal role in the recognition and removal of apoptotic cells via a PS-recognizing receptor on phagocytic cells. Furthermore, expression of PS at the cell surface can occur in a wide variety of disorders. This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal.
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            lipid scramblase
            aminophospholipid translocase
            apoptosis
            blood coagulation
            erythrocytes
            platelets
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
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      headline:Surface exposure of phosphatidylserine in pathological cells
      description:The asymmetric phospholipid distribution in plasma membranes is normally maintained by energy-dependent lipid transporters that translocate different phospholipids from one monolayer to the other against their respective concentration gradients. When cells are activated, or enter apoptosis, lipid asymmetry can be perturbed by other lipid transporters (scramblases) that shuttle phospholipids non-specifically between the two monolayers. This exposes phosphatidylserine (PS) at the cells’ outer surface. Since PS promotes blood coagulation, defective scramblase activity upon platelet stimulation causes a bleeding disorder (Scott syndrome). PS exposure also plays a pivotal role in the recognition and removal of apoptotic cells via a PS-recognizing receptor on phagocytic cells. Furthermore, expression of PS at the cell surface can occur in a wide variety of disorders. This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal.
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      dateModified:
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      pageEnd:988
      sameAs:https://doi.org/10.1007/s00018-005-4527-3
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         lipid scramblase
         aminophospholipid translocase
         apoptosis
         blood coagulation
         erythrocytes
         platelets
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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