We are analyzing https://link.springer.com/article/10.1007/s00018-004-4114-z.

Title:
Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic | Cellular and Molecular Life Sciences
Description:
Selenium (Se), once known only for its potential toxicity, is now well established as an essential trace element for mammals. Insufficient Se intake predisposes to and manifests in a variety of diseases. Recent studies have proven that it is the synthesis of selenocysteine (Sec)-containing proteins, designated selenoproteins, which represents an essential prerequisite for regular development and a long and healthy life. New transgenic mouse models analysing those selenoproteins with proven enzymatic functions displayed particular phenotypes and highlighted essential Se-dependent processes in development, growth or against specific challenges. While there is a growing molecular understanding of and general agreement on the importance of sufficiently high Se intake and undisturbed selenoprotein biosynthesis, many of the recently identified selenoproteins are still uncharacterised, and the effects and consequences of supra-physiological Se dosages are not biochemically understood. With the recent definition of the human and mouse selenoproteomes and a growing number of available tools, the Se field is now geared for a great leap forward. Se biology has already broadened our knowledge about the genetic code and about protein translation. It now holds great promises also for a better understanding of some key aspects of cancer, inflammation, fertility and prevention of age-associated diseases.
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article, selenoproteins, essential, privacy, cookies, content, selenium, schomburg, mouse, information, publish, search, life, mammals, schweizer, access, chapter, author, berlin, data, log, journal, research, molecular, cmls, köhrle, development, models, discover, springer, optional, personal, including, parties, policy, find, track, cellular, sciences, extraordinary, enigmatic, cite, explore, trace, element, intake, diseases, recent, proven, selenocysteine,

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month download article/chapter essential trace element supra-physiological se dosages genetic code related subjects privacy choices/manage cookies mouse models recently identified selenoproteins full article pdf growing molecular understanding european economic area scope submit manuscript undisturbed selenoprotein biosynthesis great leap forward holds great promises conditions privacy policy protein translation accepting optional cookies mouse selenoproteomes main content log author correspondence journal finder publish article cellular proteins check access health selenium instant access designated selenoproteins healthy life life sci privacy policy personal data selenocysteine sec books a se field se biology article schomburg article log optional cookies manage preferences essential cookies data protection article cite cookies skip subscription content similar content growing number institution subscribe

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         description:Selenium (Se), once known only for its potential toxicity, is now well established as an essential trace element for mammals. Insufficient Se intake predisposes to and manifests in a variety of diseases. Recent studies have proven that it is the synthesis of selenocysteine (Sec)-containing proteins, designated selenoproteins, which represents an essential prerequisite for regular development and a long and healthy life. New transgenic mouse models analysing those selenoproteins with proven enzymatic functions displayed particular phenotypes and highlighted essential Se-dependent processes in development, growth or against specific challenges. While there is a growing molecular understanding of and general agreement on the importance of sufficiently high Se intake and undisturbed selenoprotein biosynthesis, many of the recently identified selenoproteins are still uncharacterised, and the effects and consequences of supra-physiological Se dosages are not biochemically understood. With the recent definition of the human and mouse selenoproteomes and a growing number of available tools, the Se field is now geared for a great leap forward. Se biology has already broadened our knowledge about the genetic code and about protein translation. It now holds great promises also for a better understanding of some key aspects of cancer, inflammation, fertility and prevention of age-associated diseases.
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         dateModified:
         pageStart:1988
         pageEnd:1995
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      headline:Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic
      description:Selenium (Se), once known only for its potential toxicity, is now well established as an essential trace element for mammals. Insufficient Se intake predisposes to and manifests in a variety of diseases. Recent studies have proven that it is the synthesis of selenocysteine (Sec)-containing proteins, designated selenoproteins, which represents an essential prerequisite for regular development and a long and healthy life. New transgenic mouse models analysing those selenoproteins with proven enzymatic functions displayed particular phenotypes and highlighted essential Se-dependent processes in development, growth or against specific challenges. While there is a growing molecular understanding of and general agreement on the importance of sufficiently high Se intake and undisturbed selenoprotein biosynthesis, many of the recently identified selenoproteins are still uncharacterised, and the effects and consequences of supra-physiological Se dosages are not biochemically understood. With the recent definition of the human and mouse selenoproteomes and a growing number of available tools, the Se field is now geared for a great leap forward. Se biology has already broadened our knowledge about the genetic code and about protein translation. It now holds great promises also for a better understanding of some key aspects of cancer, inflammation, fertility and prevention of age-associated diseases.
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