We are analyzing https://link.springer.com/article/10.1007/s00018-002-8467-x.

Title:
PPARs: transcriptional effectors of fatty acids and their derivatives | Cellular and Molecular Life Sciences
Description:
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. These receptors stimulate transcription after activation by their cognate ligand and binding to the promoter of target genes. In this review, we discuss how fatty acids affect PPAR functions in the cell. We first describe the structural features of the ligand binding domains of PPARs, as defined by crystallographic analyses. We then present the ligand-binding characteristics of each of the three PPARs (α, β/δ, γ) and relate ligand activation to various cellular processes: (i) fatty acid catabolism and modulation of the inflammatory response for PPARα, (ii) embryo implantation, cell proliferation and apoptosis for PPARβ, and (iii) adipocytic differentiation, monocytic differentiation and cell cycle withdrawal for PPARγ. Finally, we present possible cross-talk between the PPAR pathway and different endocrine routes within the cell, including the thyroid hormone and retinoid pathways.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Telecommunications
Social Networks
Mobile Technology & AI

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

receptors, article, fatty, ppars, privacy, cookies, content, acids, cell, publish, search, wahli, peroxisome, proliferatoractivated, ligand, access, chapter, data, information, log, journal, research, cellular, life, transcriptional, derivatives, hihi, michalik, nuclear, hormone, differentiation, receptor, discover, author, springer, optional, personal, including, parties, policy, find, track, molecular, sciences, effectors, published, cite, explore, transcription, activation,

Topics {✒️}

peroxisome proliferator-activated receptors nuclear hormone receptors fatty acid catabolism receptors stimulate transcription month download article/chapter related subjects fatty acids privacy choices/manage cookies ligand binding domains ligand-binding characteristics bâtiment de biologie relate ligand activation full article pdf european economic area scope submit manuscript author correspondence conditions privacy policy adipocytic differentiation monocytic differentiation thyroid hormone université de lausanne accepting optional cookies cell cycle withdrawal journal finder publish cognate ligand article cellular privacy policy information personal data life sci ppar pathway books a article log optional cookies manage preferences cellular processes check access instant access subscription content similar content data protection essential cookies cookies skip article cite institution subscribe journal publish article hihi usage analysis social media varying standards

Schema {🗺️}

WebPage:
      mainEntity:
         headline:PPARs: transcriptional effectors of fatty acids and their derivatives
         description: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. These receptors stimulate transcription after activation by their cognate ligand and binding to the promoter of target genes. In this review, we discuss how fatty acids affect PPAR functions in the cell. We first describe the structural features of the ligand binding domains of PPARs, as defined by crystallographic analyses. We then present the ligand-binding characteristics of each of the three PPARs (α, β/δ, γ) and relate ligand activation to various cellular processes: (i) fatty acid catabolism and modulation of the inflammatory response for PPARα, (ii) embryo implantation, cell proliferation and apoptosis for PPARβ, and (iii) adipocytic differentiation, monocytic differentiation and cell cycle withdrawal for PPARγ. Finally, we present possible cross-talk between the PPAR pathway and different endocrine routes within the cell, including the thyroid hormone and retinoid pathways.
         datePublished:2002-05-01T00:00:00Z
         dateModified:2002-05-01T00:00:00Z
         pageStart:790
         pageEnd:798
         sameAs:https://doi.org/10.1007/s00018-002-8467-x
         keywords:
            Peroxisome proliferator-activated receptor
            nuclear receptors
            transcription
            ligand
            eicosanoids
            thiazolidinediones
            fatty acid catabolism
            differentiation.
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
         isPartOf:
            name:Cellular and Molecular Life Sciences
            issn:
               1420-9071
               1420-682X
            volumeNumber:59
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Birkhäuser-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:A.K. Hihi
               affiliation:
                     name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
                     address:
                        name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:L. Michalik
               affiliation:
                     name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
                     address:
                        name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:W. Wahli
               affiliation:
                     name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
                     address:
                        name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:PPARs: transcriptional effectors of fatty acids and their derivatives
      description: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. These receptors stimulate transcription after activation by their cognate ligand and binding to the promoter of target genes. In this review, we discuss how fatty acids affect PPAR functions in the cell. We first describe the structural features of the ligand binding domains of PPARs, as defined by crystallographic analyses. We then present the ligand-binding characteristics of each of the three PPARs (α, β/δ, γ) and relate ligand activation to various cellular processes: (i) fatty acid catabolism and modulation of the inflammatory response for PPARα, (ii) embryo implantation, cell proliferation and apoptosis for PPARβ, and (iii) adipocytic differentiation, monocytic differentiation and cell cycle withdrawal for PPARγ. Finally, we present possible cross-talk between the PPAR pathway and different endocrine routes within the cell, including the thyroid hormone and retinoid pathways.
      datePublished:2002-05-01T00:00:00Z
      dateModified:2002-05-01T00:00:00Z
      pageStart:790
      pageEnd:798
      sameAs:https://doi.org/10.1007/s00018-002-8467-x
      keywords:
         Peroxisome proliferator-activated receptor
         nuclear receptors
         transcription
         ligand
         eicosanoids
         thiazolidinediones
         fatty acid catabolism
         differentiation.
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
      isPartOf:
         name:Cellular and Molecular Life Sciences
         issn:
            1420-9071
            1420-682X
         volumeNumber:59
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Birkhäuser-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:A.K. Hihi
            affiliation:
                  name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
                  address:
                     name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:L. Michalik
            affiliation:
                  name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
                  address:
                     name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:W. Wahli
            affiliation:
                  name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
                  address:
                     name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences
      issn:
         1420-9071
         1420-682X
      volumeNumber:59
Organization:
      name:Birkhäuser-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
      address:
         name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
         type:PostalAddress
      name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
      address:
         name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
         type:PostalAddress
      name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
      address:
         name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:A.K. Hihi
      affiliation:
            name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
            address:
               name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
               type:PostalAddress
            type:Organization
      name:L. Michalik
      affiliation:
            name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
            address:
               name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
               type:PostalAddress
            type:Organization
      name:W. Wahli
      affiliation:
            name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne
            address:
               name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
      name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
      name:Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, Lausanne, Switzerland
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(29)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.92s.

LINK . SPRINGER . COM {}