We are analyzing https://link.springer.com/article/10.1007/s00011-009-0063-1.

Title:
Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes | Inflammation Research
Description:
Objective and design This study aims to investigate the effects of curcumin (Cur) on the extracellular matrix protein metabolism of articular chondrocytes and on their production of inflammatory mediators. Methods Human chondrocytes in alginate beads and human cartilage explants were cultured in the absence or in the presence of interleukin (IL)-1beta (10−11 M) and with or without Cur (5–20 μM). Nitric oxide (NO) synthesis was measured by the Griess spectrophotometric method; prostaglandin (PG) E2 by a specific radioimmunoassay; and IL-6, IL-8, aggrecan (Agg), matrix metalloproteinase (MMP)-3, and tissue inhibitor of metalloproteinase (TIMP)-1 by specific enzyme-amplified immunoassays. Proteoglycan degradation was evaluated by the release of 35S-glycosaminoglycans (GAG) from human cartilage explants. Results In alginate beads and cartilage explant models, Cur inhibited the basal and the IL-1beta-stimulated NO, PGE2, IL-6, IL-8, and MMP-3 production by human chondrocytes in a concentration-dependent manner. The TIMP-1 and the Agg productions were not modified. In the basal condition, 35S-GAG release from cartilage explants was decreased by Cur. Conclusions Curcumin was a potent inhibitor of the production of inflammatory and catabolic mediators by chondrocytes, suggesting that this natural compound could be efficient in the treatment of osteoarthritis.
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article, google, scholar, pubmed, cas, curcumin, chondrocytes, cartilage, human, res, osteoarthritis, arthritis, metalloproteinase, production, matrix, research, henrotin, effects, articular, interleukin, biochem, expression, privacy, cookies, content, inflammation, immunol, activation, information, publish, search, mediators, sanchez, cur, alginate, beads, prostaglandin, access, inhibition, agent, cancer, data, log, journal, inhibits, mathyhartert, jacquemondcollet, priem, study, metabolism,

Topics {✒️}

il-1beta-stimulated c-28/i2 chondrocytes drives inflammation-induced osteoclastogenesis nf-kappa b-dependent genes month download article/chapter il-1β-induced oxidative stress specific enzyme-amplified immunoassays nf-kappab transcription factors il-l1beta-induced inhibition interleukin-1beta-stimulated chondrocytes full article pdf cartilage research unit interleukin-1-stimulated map kinases antigen-induced arthritis privacy choices/manage cookies anti-inflammatory agent article mathy-hartert prostaglandin e2 production concentration-dependent manner human chondrocytes stimulated inflammatory mediators metalloproteinase-3 genes expression anti-tumour promoter il-1beta-stimulated nuclear factor kappa cartilage chondrocytes mechanism tumor necrosis factor lymphocyte-derived cytokines il-1 receptor antagonist cartilage explant models cartilage collagen breakdown european economic area scope submit manuscript related subjects expert consensus guidelines nonsteroidal antiinflammatory drugs equine postanaesthetic myositis curr drug targets skillful technical assistance chu sart-tilman exp cell res vet res commun curcumin-mediated protection beta1-integrin expression chemopreventive agent curcumin catabolic mediators conditions privacy policy griess spectrophotometric method collagen type ii lohmann-matthes ml pre-malignant lesions

Questions {❓}

Antioxidant to treat osteoarthritis: dream or reality?
Oxygen and reactive oxygen species in cartilage degradation: friends or foes?

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         description:This study aims to investigate the effects of curcumin (Cur) on the extracellular matrix protein metabolism of articular chondrocytes and on their production of inflammatory mediators. Human chondrocytes in alginate beads and human cartilage explants were cultured in the absence or in the presence of interleukin (IL)-1beta (10−11 M) and with or without Cur (5–20 μM). Nitric oxide (NO) synthesis was measured by the Griess spectrophotometric method; prostaglandin (PG) E2 by a specific radioimmunoassay; and IL-6, IL-8, aggrecan (Agg), matrix metalloproteinase (MMP)-3, and tissue inhibitor of metalloproteinase (TIMP)-1 by specific enzyme-amplified immunoassays. Proteoglycan degradation was evaluated by the release of 35S-glycosaminoglycans (GAG) from human cartilage explants. In alginate beads and cartilage explant models, Cur inhibited the basal and the IL-1beta-stimulated NO, PGE2, IL-6, IL-8, and MMP-3 production by human chondrocytes in a concentration-dependent manner. The TIMP-1 and the Agg productions were not modified. In the basal condition, 35S-GAG release from cartilage explants was decreased by Cur. Curcumin was a potent inhibitor of the production of inflammatory and catabolic mediators by chondrocytes, suggesting that this natural compound could be efficient in the treatment of osteoarthritis.
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