We are analyzing https://link.springer.com/article/10.1007/s00011-006-0067-z.

Title:
The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis | Inflammation Research
Description:
Objective Curcumin and quercetin are antioxidant molecules with anti-proliferative, anti-inflammatory and immunosuppressive activities. The objective of this study was to investigate the inhibitory activity of these agents using four assays of inflammatory aspects of arthritis. Methods Crystal-induced neutrophil activation was measured by luminol-dependent chemiluminescence. Synoviocyte proliferation was measured by an MTS assay using HIG-82 rabbit synoviocytes in cell culture. Chondrocyte (cultured primary cells) expression of the matrix metalloproteinases collagenase and stromelysin was measured by Northern Blot analysis. Angiogenesis was measured using the chorioallantoic membrane of the chick embryo. Results Both agents inhibited neutrophil activation, synoviocyte proliferation and angiogenesis. Curcumin strongly inhibited collagenase and stromelysin expression at micromolar concentrations whereas quercetin had no effect in this assay. Conclusion These studies suggest that curcumin and to a lesser extent quercetin may offer therapeutic potential for the treatment of crystal-induced arthritis or rheumatoid arthritis.
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Keywords {🔍}

arthritis, article, curcumin, quercetin, research, privacy, cookies, content, inflammatory, rheumatoid, access, information, publish, search, measured, data, log, journal, antioxidants, jackson, higo, hunter, burt, discover, author, springer, optional, analysis, personal, parties, policy, find, track, inflammation, inhibit, processes, cite, explore, objective, study, agents, crystalinduced, neutrophil, activation, synoviocyte, proliferation, assay, expression, collagenase, stromelysin,

Topics {✒️}

curcumin-treated collagen-induced arthritis month download article/chapter crystal-induced arthritis privacy choices/manage cookies full article pdf rheumatoid arthritis matrix metalloproteinases collagenase lesser extent quercetin european economic area scope submit manuscript luminol-dependent chemiluminescence hig-82 rabbit synoviocytes cultured primary cells offer therapeutic potential related subjects conditions privacy policy check access instant access northern blot analysis accepting optional cookies main content log antioxidants curcumin journal finder publish author correspondence article log metabolic effects article cite article jackson privacy policy personal data books a anti-inflammatory inflammatory aspects optional cookies manage preferences arthritis objective curcumin data protection essential cookies cookies skip subscription content similar content usage analysis institution subscribe journal publish social media varying standards april 2006 volume 55 antioxidant molecules anti-proliferative

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