We are analyzing https://link.springer.com/article/10.1007/s13346-024-01710-x.

Title:
Exosome-based drug delivery systems for enhanced neurological therapeutics | Drug Delivery and Translational Research
Description:
Exosomes are small extracellular vesicles naturally secreted by cells into body fluids, enriched with bioactive molecules such as RNAs, proteins, and lipids. These nanosized vesicles play a crucial role in physiological and pathological processes by facilitating intercellular communication and modulating cellular responses, particularly within the central nervous system (CNS). Their ability to cross the blood–brain barrier and reflect the characteristics of their parent cells makes exosomal cargo a promising candidate for biomarkers in the early diagnosis and clinical assessment of neurological conditions. This review offers a comprehensive overview of current knowledge on the characterization of mammalian-derived exosomes, their application as drug delivery systems for neurological disorders, and ongoing clinical trials involving exosome-loaded cargo. Despite their promising attributes, a significant challenge remains the lack of standardized isolation methods, as current techniques are often complex, costly, and require sophisticated equipment, affecting the scalability and affordability of exosome-based therapies. The review highlights the engineering potential of exosomes, emphasizing their ability to be customized for targeted therapeutic delivery through surface modification or conjugation. Future advancements in addressing these challenges and leveraging the unique properties of exosomes could lead to innovative and effective therapeutic strategies in neurology. Graphical Abstract
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Keywords {🔍}

pubmed, google, scholar, cas, central, exosomes, stem, delivery, wang, extracellular, liu, vesicles, brain, disease, cell, cells, mesenchymal, drug, zhang, chen, mol, treatment, article, neurological, potential, front, exosomal, therapeutic, model, alzheimers, stroke, role, system, ther, cellderived, res, clinical, huang, neurosci, sci, parkinsons, zhu, function, review, yang, therapy, int, multiple, sclerosis, zhao,

Topics {✒️}

exosome-shuttled mir-92b-3p wnt/β-catenin signaling pathway endothelial cells-derived exosomes mir-133b modified mscs exosome-encapsulated antisense oligonucleotides neural cell-derived exosomes glia-derived extracellular vesicles doxorubicin-loaded nanoparticle coated month download article/chapter plant-derived extracellular vesicles exosome-enriched extracellular particles neuron-glia crosstalk perspective rvg-modified exosomes derived akt/gsk-3β pathway mesenchymal stromal cell exosome-based drug delivery anti-tumor immune response reduce amyloid-β deposition amyloid-β-caused neurotoxicity plasma exosomal mirna-122-5p nerve injury-induced pain neural stem cells targeting ampk/mtor signaling central nervous system exosome-based regenerative rehabilitation prevent abnormal neurogenesis inhibiting neuronal p53/caspase-3 alleviated cognitive impairment glucose deprivation-induced autophagy glioma-targeted delivery blood–brain barrier blood-brain barrier astrocyte-derived exosomes drug delivery systems early single-dose treatment plant-derived exosome plant derived exosome exosomal microrna signatures exosome-mediated delivery drug delivery system translational research aims glioblastoma-derived exosomes improved glioma treatment related subjects improve stability profile glioblastoma animal models cell-based therapy experimental rat model article drug delivery neurological disease progression

Questions {❓}

Exosomal neurofilament light: A prognostic biomarker for remote symptoms after mild traumatic brain injury?
Exosomes in alpha-synucleinopathies: propagators of pathology or potential candidates for nanotherapeutics?

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