We are analyzing https://link.springer.com/article/10.1007/s10571-009-9368-4.

Title:
Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery | Cellular and Molecular Neurobiology
Description:
In addition to regulating blood pressure, Angiotensin II (Ang II) exerts powerful pro-inflammatory effects in hypertension through stimulation of its AT1 receptors, most clearly demonstrated in peripheral arteries and in the cerebral vasculature. Administration of Ang II receptor blockers (ARBs) decreases hypertension-related vascular inflammation in peripheral organs. In rodent models of genetic hypertension, ARBs reverse the inflammation in the cerebral microcirculation. We hypothesized that ARBs could be effective in inflammatory conditions beyond hypertension. Our more recent studies, summarized here, indicate that this is indeed the case. We used the model of systemic administration of the bacterial endotoxin lipopolysaccharide (LPS). LPS produces a robust initial inflammatory reaction, the innate immune response, in peripheral organs and in the brain. Pretreatment with the ARB candesartan significantly diminishes the response to LPS, including reduction of pro-inflammatory cytokine release to the general circulation and decreased production and release of the pro-inflammatory adrenal hormone aldosterone. In addition, the ARB very significantly decreased the LPS-induced gene expression of pro-inflammatory cytokines and microglia activation in the brain. Our results demonstrate that AT1 receptor activity is essential for the unrestricted development of full-scale innate immune response in the periphery and in the brain. ARBs, due to their immune response-limiting properties, may be considered as therapeutically useful in a number of inflammatory diseases of the peripheral organs and the brain.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,603,974 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

google, scholar, pubmed, article, cas, receptor, angiotensin, brain, saavedra, rats, peripheral, dois, inflammation, lipopolysaccharide, cell, physiol, lps, innate, expression, rat, effects, cerebral, administration, inflammatory, immune, hypertensive, blockade, res, system, pavel, blood, proinflammatory, hypertension, receptors, response, activation, antagonist, mol, health, neurobiol, research, benicky, vascular, stroke, factor, stress, sci, quan, disease, privacy,

Topics {✒️}

cold-restraint stress-induced increase month download article/chapter hypothalamic-pituitary-adrenal axis activity blood–brain barrier-independent pathways rat hypothalamo-pituitary-adrenal axis angiotensin-ii receptor subtypes at1 receptor antagonism renin-angiotensin system cytokine-induced sickness behavior receptor antagonist decreases nf-κb/iκb system hypothalamic-pituitary-adrenal response lps-induced gene expression pro-inflammatory cytokine mrnas isolation stress-induced decrease immune response-limiting properties brain-immune communications pathways at1 receptor activity pro-inflammatory cytokine release pro-inflammatory il-1β full article pdf anti-inflammatory il-10 cytokines at1 receptor antagonists angiotensin receptor blockers circulating inflammatory mediators central nervous system limiting inflammatory responses privacy choices/manage cookies brain angiotensin ii signaling cascades induced pro-inflammatory cytokines anti-inflammatory effects receptor 4-dependent pathway cortical crf1 receptor molecular neurobiology aims endotoxin-induced uveitis lps-induced production bacterial endotoxin lipopolysaccharide innate immune response alpha il-1β regulating blood pressure cerebral blood flow cns triggers neurodegeneration repeated immune challenge intramural research programs targeting bacterial endotoxin rel/nf-kappa tissue cytokine expression article cellular inflammatory signaling molecules

Questions {❓}

Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important?
Quan N (2008) Immune-to-brain signaling: how important are the blood–brain barrier-independent pathways?
Rogers J, Mastroeni D, Leonard B, Joyce J, Grover A (2007) Neuroinflammation in Alzheimer’s disease and Parkinson’s disease: are microglia pathogenic in either disorder?
Singh AK, Jiang Y (2004) How does peripheral lipopolysaccharide induce gene expression in the brain of rats?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery
         description:In addition to regulating blood pressure, Angiotensin II (Ang II) exerts powerful pro-inflammatory effects in hypertension through stimulation of its AT1 receptors, most clearly demonstrated in peripheral arteries and in the cerebral vasculature. Administration of Ang II receptor blockers (ARBs) decreases hypertension-related vascular inflammation in peripheral organs. In rodent models of genetic hypertension, ARBs reverse the inflammation in the cerebral microcirculation. We hypothesized that ARBs could be effective in inflammatory conditions beyond hypertension. Our more recent studies, summarized here, indicate that this is indeed the case. We used the model of systemic administration of the bacterial endotoxin lipopolysaccharide (LPS). LPS produces a robust initial inflammatory reaction, the innate immune response, in peripheral organs and in the brain. Pretreatment with the ARB candesartan significantly diminishes the response to LPS, including reduction of pro-inflammatory cytokine release to the general circulation and decreased production and release of the pro-inflammatory adrenal hormone aldosterone. In addition, the ARB very significantly decreased the LPS-induced gene expression of pro-inflammatory cytokines and microglia activation in the brain. Our results demonstrate that AT1 receptor activity is essential for the unrestricted development of full-scale innate immune response in the periphery and in the brain. ARBs, due to their immune response-limiting properties, may be considered as therapeutically useful in a number of inflammatory diseases of the peripheral organs and the brain.
         datePublished:2009-03-04T00:00:00Z
         dateModified:2009-03-04T00:00:00Z
         pageStart:781
         pageEnd:792
         sameAs:https://doi.org/10.1007/s10571-009-9368-4
         keywords:
            Renin-angiotensin system
            LPS
            Brain inflammation
            Microglia
            AT1 receptor antagonist
            Neurosciences
            Cell Biology
            Neurobiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig5_HTML.gif
         isPartOf:
            name:Cellular and Molecular Neurobiology
            issn:
               1573-6830
               0272-4340
            volumeNumber:29
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Julius Benicky
               affiliation:
                     name:National Institute of Mental Health, National Institutes of Health
                     address:
                        name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Enrique Sánchez-Lemus
               affiliation:
                     name:National Institute of Mental Health, National Institutes of Health
                     address:
                        name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jaroslav Pavel
               affiliation:
                     name:National Institute of Mental Health, National Institutes of Health
                     address:
                        name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Juan M. Saavedra
               affiliation:
                     name:National Institute of Mental Health, National Institutes of Health
                     address:
                        name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery
      description:In addition to regulating blood pressure, Angiotensin II (Ang II) exerts powerful pro-inflammatory effects in hypertension through stimulation of its AT1 receptors, most clearly demonstrated in peripheral arteries and in the cerebral vasculature. Administration of Ang II receptor blockers (ARBs) decreases hypertension-related vascular inflammation in peripheral organs. In rodent models of genetic hypertension, ARBs reverse the inflammation in the cerebral microcirculation. We hypothesized that ARBs could be effective in inflammatory conditions beyond hypertension. Our more recent studies, summarized here, indicate that this is indeed the case. We used the model of systemic administration of the bacterial endotoxin lipopolysaccharide (LPS). LPS produces a robust initial inflammatory reaction, the innate immune response, in peripheral organs and in the brain. Pretreatment with the ARB candesartan significantly diminishes the response to LPS, including reduction of pro-inflammatory cytokine release to the general circulation and decreased production and release of the pro-inflammatory adrenal hormone aldosterone. In addition, the ARB very significantly decreased the LPS-induced gene expression of pro-inflammatory cytokines and microglia activation in the brain. Our results demonstrate that AT1 receptor activity is essential for the unrestricted development of full-scale innate immune response in the periphery and in the brain. ARBs, due to their immune response-limiting properties, may be considered as therapeutically useful in a number of inflammatory diseases of the peripheral organs and the brain.
      datePublished:2009-03-04T00:00:00Z
      dateModified:2009-03-04T00:00:00Z
      pageStart:781
      pageEnd:792
      sameAs:https://doi.org/10.1007/s10571-009-9368-4
      keywords:
         Renin-angiotensin system
         LPS
         Brain inflammation
         Microglia
         AT1 receptor antagonist
         Neurosciences
         Cell Biology
         Neurobiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-009-9368-4/MediaObjects/10571_2009_9368_Fig5_HTML.gif
      isPartOf:
         name:Cellular and Molecular Neurobiology
         issn:
            1573-6830
            0272-4340
         volumeNumber:29
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Julius Benicky
            affiliation:
                  name:National Institute of Mental Health, National Institutes of Health
                  address:
                     name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Enrique Sánchez-Lemus
            affiliation:
                  name:National Institute of Mental Health, National Institutes of Health
                  address:
                     name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jaroslav Pavel
            affiliation:
                  name:National Institute of Mental Health, National Institutes of Health
                  address:
                     name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juan M. Saavedra
            affiliation:
                  name:National Institute of Mental Health, National Institutes of Health
                  address:
                     name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Neurobiology
      issn:
         1573-6830
         0272-4340
      volumeNumber:29
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Institute of Mental Health, National Institutes of Health
      address:
         name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:National Institute of Mental Health, National Institutes of Health
      address:
         name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:National Institute of Mental Health, National Institutes of Health
      address:
         name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:National Institute of Mental Health, National Institutes of Health
      address:
         name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Julius Benicky
      affiliation:
            name:National Institute of Mental Health, National Institutes of Health
            address:
               name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Enrique Sánchez-Lemus
      affiliation:
            name:National Institute of Mental Health, National Institutes of Health
            address:
               name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Jaroslav Pavel
      affiliation:
            name:National Institute of Mental Health, National Institutes of Health
            address:
               name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Juan M. Saavedra
      affiliation:
            name:National Institute of Mental Health, National Institutes of Health
            address:
               name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
      name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
      name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
      name:Department of Health and Human Services, Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(278)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.08s.

LINK . SPRINGER . COM {}