We are analyzing https://link.springer.com/article/10.1007/bf02919638.

Title:
The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity | General Thoracic and Cardiovascular Surgery
Description:
Objective: It has recently been defined that levels of tetrahydrobiopterin, a cofactor of nitric oxide synthase, decreases under some disease conditions including atherosclerosis, hypercholesterolemia, diabetes, and ischemia-reperfusion. The present study was designed to investigate whether or not a deficiency in tetrahydrobiopterin affected vasoactivation in vivo and in vitro.Subjects and Methods: Male Sprague-Dawley rats were divided into two groups, and given either 2, 4-diamino-6-hydroxypyrimidine (DAHP), a selective inhibitor of tetrahydrobiopterin production, or a vehicle (10% polyethylene glycol 400 in 5% glucose, 20 ml/kg), intraperitoneally at 24 hr prior to examination. Responses to several vasodilating agents were examined in both pretreatment groups in vivo and in vitro. Furthermore, the isolated heart was perfused with a 37°C Krebs-Henseleit solution for 30 min. The effects of insufficient tetrahydrobiopterin on the left ventricular function were examined. Moreover, nitrite plus nitrate (NOx) in the coronary effluent was examined in both groups.Results: Depressor and vasodilatation responses to an endothelium-dependent vasodilator were significantly attenuated in the DAHP Group in comparison with those in the vehicle Control Group, while the endothelium-independent vasodilator caused equivalent depressor and vasodilatation responses between the two groups. The NOx levels in the coronary effluent were lower in the DAHP Group than in the Control Group (p<0.05). The cardiovascular parameters were also lower in the DAHP Group than in the Control Group. Conclusions: We concluded from these findings that a deficiency in tetrahydrobiopterin aggravated endothelial dysfunction and the left ventricular dysfunction. These findings were consistent with the hypothesis that decreased levels of tetrahydrobiopterin may cause cardiac and vascular dysfunction.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Social Networks
Insurance
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,734,772 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

article, tetrahydrobiopterin, google, scholar, pubmed, cas, endothelial, nitric, function, oxide, dysfunction, content, effect, synthase, group, privacy, cookies, journal, cardiovascular, yamashiro, access, publish, search, miyagi, disease, dahp, vasodilator, injury, data, information, log, research, surgery, kuniyoshi, arakaki, levels, cofactor, ischemiareperfusion, vivo, groups, responses, examined, coronary, endotheliumdependent, control, vascular, discover, biochem, res, cosentino,

Topics {✒️}

month download article/chapter nitric oxide synthase male sprague-dawley rats endothelium-derived relaxing factor related subjects ischemia-reperfusion injury nitric oxide tetrahidrobiopterin synthasis reduces full article pdf privacy choices/manage cookies vascular endothelial function left ventricular dysfunction endothelium-dependent vasodilator aortic endothelial cells check access instant access spontaneously hypertensive rats guinea pig hearts conditions privacy policy european economic area krebs-henseleit solution dexamethasone suppression test functioning adrenal incidentaloma reactive hyperemia response experimental endotoxic shock left ventricular function tetrahydrobiopterin affected vasoactivation tetrahydrobiopterin-dependent formation ischemia-reperfusion article yamashiro vascular dysfunction accepting optional cookies coronary artery disease reperfusion injury lüscher tf endothelial dysfunction cardiovascular surgery aims main content log tetrahydrobiopterin-dependent inhibition article log journal finder publish article cite vascular disease endothelial function vehicle control group critical cofactor subjects tetrahydrobiopterin production privacy policy personal data

Questions {❓}

Tetrahydrobiopterin: A critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity
         description:Objective: It has recently been defined that levels of tetrahydrobiopterin, a cofactor of nitric oxide synthase, decreases under some disease conditions including atherosclerosis, hypercholesterolemia, diabetes, and ischemia-reperfusion. The present study was designed to investigate whether or not a deficiency in tetrahydrobiopterin affected vasoactivation in vivo and in vitro.Subjects and Methods: Male Sprague-Dawley rats were divided into two groups, and given either 2, 4-diamino-6-hydroxypyrimidine (DAHP), a selective inhibitor of tetrahydrobiopterin production, or a vehicle (10% polyethylene glycol 400 in 5% glucose, 20 ml/kg), intraperitoneally at 24 hr prior to examination. Responses to several vasodilating agents were examined in both pretreatment groups in vivo and in vitro. Furthermore, the isolated heart was perfused with a 37°C Krebs-Henseleit solution for 30 min. The effects of insufficient tetrahydrobiopterin on the left ventricular function were examined. Moreover, nitrite plus nitrate (NOx) in the coronary effluent was examined in both groups.Results: Depressor and vasodilatation responses to an endothelium-dependent vasodilator were significantly attenuated in the DAHP Group in comparison with those in the vehicle Control Group, while the endothelium-independent vasodilator caused equivalent depressor and vasodilatation responses between the two groups. The NOx levels in the coronary effluent were lower in the DAHP Group than in the Control Group (p<0.05). The cardiovascular parameters were also lower in the DAHP Group than in the Control Group. Conclusions: We concluded from these findings that a deficiency in tetrahydrobiopterin aggravated endothelial dysfunction and the left ventricular dysfunction. These findings were consistent with the hypothesis that decreased levels of tetrahydrobiopterin may cause cardiac and vascular dysfunction.
         datePublished:
         dateModified:
         pageStart:472
         pageEnd:477
         sameAs:https://doi.org/10.1007/BF02919638
         keywords:
            tetrahydrobiopterin
            nitric oxide synthase
            nitric oxide
            endothelial dysfunction
            Thoracic Surgery
            Cardiac Surgery
            Cardiology
            Surgical Oncology
         image:
         isPartOf:
            name:The Japanese Journal of Thoracic and Cardiovascular Surgery
            issn:
               1863-2092
               1344-4964
            volumeNumber:50
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Satoshi Yamashiro
               affiliation:
                     name:University of the Ryukyus
                     address:
                        name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yukio Kuniyoshi
               affiliation:
                     name:University of the Ryukyus
                     address:
                        name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Katsuya Arakaki
               affiliation:
                     name:University of the Ryukyus
                     address:
                        name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kazufumi Miyagi
               affiliation:
                     name:University of the Ryukyus
                     address:
                        name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kageharu Koja
               affiliation:
                     name:University of the Ryukyus
                     address:
                        name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity
      description:Objective: It has recently been defined that levels of tetrahydrobiopterin, a cofactor of nitric oxide synthase, decreases under some disease conditions including atherosclerosis, hypercholesterolemia, diabetes, and ischemia-reperfusion. The present study was designed to investigate whether or not a deficiency in tetrahydrobiopterin affected vasoactivation in vivo and in vitro.Subjects and Methods: Male Sprague-Dawley rats were divided into two groups, and given either 2, 4-diamino-6-hydroxypyrimidine (DAHP), a selective inhibitor of tetrahydrobiopterin production, or a vehicle (10% polyethylene glycol 400 in 5% glucose, 20 ml/kg), intraperitoneally at 24 hr prior to examination. Responses to several vasodilating agents were examined in both pretreatment groups in vivo and in vitro. Furthermore, the isolated heart was perfused with a 37°C Krebs-Henseleit solution for 30 min. The effects of insufficient tetrahydrobiopterin on the left ventricular function were examined. Moreover, nitrite plus nitrate (NOx) in the coronary effluent was examined in both groups.Results: Depressor and vasodilatation responses to an endothelium-dependent vasodilator were significantly attenuated in the DAHP Group in comparison with those in the vehicle Control Group, while the endothelium-independent vasodilator caused equivalent depressor and vasodilatation responses between the two groups. The NOx levels in the coronary effluent were lower in the DAHP Group than in the Control Group (p<0.05). The cardiovascular parameters were also lower in the DAHP Group than in the Control Group. Conclusions: We concluded from these findings that a deficiency in tetrahydrobiopterin aggravated endothelial dysfunction and the left ventricular dysfunction. These findings were consistent with the hypothesis that decreased levels of tetrahydrobiopterin may cause cardiac and vascular dysfunction.
      datePublished:
      dateModified:
      pageStart:472
      pageEnd:477
      sameAs:https://doi.org/10.1007/BF02919638
      keywords:
         tetrahydrobiopterin
         nitric oxide synthase
         nitric oxide
         endothelial dysfunction
         Thoracic Surgery
         Cardiac Surgery
         Cardiology
         Surgical Oncology
      image:
      isPartOf:
         name:The Japanese Journal of Thoracic and Cardiovascular Surgery
         issn:
            1863-2092
            1344-4964
         volumeNumber:50
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Satoshi Yamashiro
            affiliation:
                  name:University of the Ryukyus
                  address:
                     name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yukio Kuniyoshi
            affiliation:
                  name:University of the Ryukyus
                  address:
                     name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Katsuya Arakaki
            affiliation:
                  name:University of the Ryukyus
                  address:
                     name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kazufumi Miyagi
            affiliation:
                  name:University of the Ryukyus
                  address:
                     name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kageharu Koja
            affiliation:
                  name:University of the Ryukyus
                  address:
                     name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:The Japanese Journal of Thoracic and Cardiovascular Surgery
      issn:
         1863-2092
         1344-4964
      volumeNumber:50
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of the Ryukyus
      address:
         name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
         type:PostalAddress
      name:University of the Ryukyus
      address:
         name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
         type:PostalAddress
      name:University of the Ryukyus
      address:
         name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
         type:PostalAddress
      name:University of the Ryukyus
      address:
         name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
         type:PostalAddress
      name:University of the Ryukyus
      address:
         name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Satoshi Yamashiro
      affiliation:
            name:University of the Ryukyus
            address:
               name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Yukio Kuniyoshi
      affiliation:
            name:University of the Ryukyus
            address:
               name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Katsuya Arakaki
      affiliation:
            name:University of the Ryukyus
            address:
               name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Kazufumi Miyagi
      affiliation:
            name:University of the Ryukyus
            address:
               name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Kageharu Koja
      affiliation:
            name:University of the Ryukyus
            address:
               name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
               type:PostalAddress
            type:Organization
PostalAddress:
      name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
      name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
      name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
      name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
      name:2nd Department of Surgery, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(84)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.92s.

LINK . SPRINGER . COM {}