We are analyzing https://link.springer.com/article/10.1007/bf02900689.

Title:
Prophylaxis of tumor through oral administration of IL-12 GM-CSF gene carried by live attenuated salmonella | Science Bulletin
Description:
A live attenuated AraA- autotrophic mutant ofSalmonella typhimurium (SL3261) was used as carrier for eukaryotic expression vectors EGFPN1, pCMVmIL-12, pCMVhIL-12, pCMVmGM-CSF and pCMVhGM-CSF and was administered orally to BALB/c and C57BL/6 mice. After 6 weeks, these mice were challenged with 4T1 and Lewis tumor cells respectively. GFP expression and gene integration could be detected in mice’s livers, spleens, intestines, kidneys and tumors. The serum level of cytokines increased significantly in treated mice, so did the ratio of CD 8 + /CD 4 + , which resulted in the tumor regression and prolongation of the survival time of those mice. These researches laid an experimental foundation for the tumor gene therapy using live attenuated salmonella.
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article, gene, google, scholar, cas, pubmed, oral, attenuated, salmonella, therapy, tumor, privacy, cookies, content, live, typhimurium, mice, access, publish, research, search, science, administration, yuhua, kunyuan, xie, cancer, immunity, data, information, log, journal, gmcsf, hui, guo, cells, interleukin, discover, blood, induction, nature, granulocytemacrophage, colony, stimulating, factor, download, author, china, springer, optional,

Topics {✒️}

month download article/chapter cancer gene therapy live attenuated salmonella tumor gene therapy achieves long-term survival vaccine-induced tumor immunity state key laboratory full article pdf privacy choices/manage cookies google scholar oral dna vaccination related subjects article yuhua european economic area cytokines increased significantly direct intratumoral injection enhanced adjuvant effect oral administration conditions privacy policy gene integration gene transfer mouse langerhans cells lewis tumor cells military medical university accepting optional cookies main content log salmonella typhimurium medina check access instant access journal finder publish gm-csf author correspondence article log oral vaccine nature biotech life science article cite interleukin-12 compared guo kunyuan privacy policy personal data books a attenuatedsalmonella typhimurium pcmvmgm-csf pcmvhgm-csf optional cookies manage preferences wang feng gfp expression

Schema {🗺️}

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         description:A live attenuated AraA- autotrophic mutant ofSalmonella typhimurium (SL3261) was used as carrier for eukaryotic expression vectors EGFPN1, pCMVmIL-12, pCMVhIL-12, pCMVmGM-CSF and pCMVhGM-CSF and was administered orally to BALB/c and C57BL/6 mice. After 6 weeks, these mice were challenged with 4T1 and Lewis tumor cells respectively. GFP expression and gene integration could be detected in mice’s livers, spleens, intestines, kidneys and tumors. The serum level of cytokines increased significantly in treated mice, so did the ratio of CD 8 + /CD 4 + , which resulted in the tumor regression and prolongation of the survival time of those mice. These researches laid an experimental foundation for the tumor gene therapy using live attenuated salmonella.
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      headline:Prophylaxis of tumor through oral administration of IL-12 GM-CSF gene carried by live attenuated salmonella
      description:A live attenuated AraA- autotrophic mutant ofSalmonella typhimurium (SL3261) was used as carrier for eukaryotic expression vectors EGFPN1, pCMVmIL-12, pCMVhIL-12, pCMVmGM-CSF and pCMVhGM-CSF and was administered orally to BALB/c and C57BL/6 mice. After 6 weeks, these mice were challenged with 4T1 and Lewis tumor cells respectively. GFP expression and gene integration could be detected in mice’s livers, spleens, intestines, kidneys and tumors. The serum level of cytokines increased significantly in treated mice, so did the ratio of CD 8 + /CD 4 + , which resulted in the tumor regression and prolongation of the survival time of those mice. These researches laid an experimental foundation for the tumor gene therapy using live attenuated salmonella.
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      dateModified:
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      pageEnd:1111
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         attenuated salmonella
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         Earth Sciences
         Engineering
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