We are analyzing https://link.springer.com/article/10.1007/bf02890024.

Title:
Complement activation in amyloid plaques in Alzheimer’s dementia | Virchows Archiv B Cell Pathology
Description:
Amyloid plaques in Alzheimer’s dementia contain complement factors C1q, C4 and C3. In the present study we demonstrate complement activation in amyloid plaques using immunoenzymatical techniques and specific antibodies against subunits of individual complement components and activated complement products. Amyloid plaques contain C1q and activated C3 fragments (C3c and C3d, g) but no C1s and C3a. These findings demonstrate that the complement components are not passively bound to the amyloid plaque structures but are the result of an activation process. The role of complement activation in the genesis of senile plaques is discussed.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,734,772 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

article, google, scholar, amyloid, cas, complement, alzheimers, pubmed, plaques, disease, activation, dementia, eikelenboom, senile, plaque, nature, privacy, cookies, content, virchows, hack, stam, access, publish, search, rozemuller, study, products, inhibitor, cell, protein, immunol, pangburn, müllereberhard, springer, netherlands, data, information, log, journal, research, archiv, component, chapter, discover, protease, acta, neuropathol, berl, pathol,

Topics {✒️}

month download article/chapter immuno-electron-microscopic localisation article virchows archiv müller-eberhard hj amyloid plaque structures full article pdf article complement activation privacy choices/manage cookies senile plaque amyloid amyloid plaque formation a4 amyloid mrna blood-brain barrier blood-borne cells serine proteinase inhibitors activated complement products brain amyloid deposits european economic area scrapie-affected mice van mierlo gm york tokyo hongkong cerebral senile amyloid demonstrate complement activation cell-surface receptor activated c3 fragments initial c3 convertase conditions privacy policy internal thioester bond pangburn mk complexed c1 inhibitor individual complement components amyloid precursor mrna masters cl accepting optional cookies related subjects nuijens jh article eikelenboom alternative complement pathway activation products virchows archiv complement factors c1q article log journal finder publish hack ce december 1988 volume 56 check access pouplard-barthelaix instant access amyloid plaques hack rights article cite

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Complement activation in amyloid plaques in Alzheimer’s dementia
         description:Amyloid plaques in Alzheimer’s dementia contain complement factors C1q, C4 and C3. In the present study we demonstrate complement activation in amyloid plaques using immunoenzymatical techniques and specific antibodies against subunits of individual complement components and activated complement products. Amyloid plaques contain C1q and activated C3 fragments (C3c and C3d, g) but no C1s and C3a. These findings demonstrate that the complement components are not passively bound to the amyloid plaque structures but are the result of an activation process. The role of complement activation in the genesis of senile plaques is discussed.
         datePublished:
         dateModified:
         pageStart:259
         pageEnd:262
         sameAs:https://doi.org/10.1007/BF02890024
         keywords:
            Alzheimer’s dementia
            Amyloid plaques
            Complement activation
            Pathology
            Cell Biology
         image:
         isPartOf:
            name:Virchows Archiv B
            issn:
               0340-6075
            volumeNumber:56
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:P. Eikelenboom
               affiliation:
                     name:Free University
                     address:
                        name:Department of Psychiatry, Free University, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:C. E. Hack
               affiliation:
                     name:University of Amsterdam
                     address:
                        name:Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J. M. Rozemuller
               affiliation:
                     name:Free University
                     address:
                        name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:F. C. Stam
               affiliation:
                     name:Free University
                     address:
                        name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Complement activation in amyloid plaques in Alzheimer’s dementia
      description:Amyloid plaques in Alzheimer’s dementia contain complement factors C1q, C4 and C3. In the present study we demonstrate complement activation in amyloid plaques using immunoenzymatical techniques and specific antibodies against subunits of individual complement components and activated complement products. Amyloid plaques contain C1q and activated C3 fragments (C3c and C3d, g) but no C1s and C3a. These findings demonstrate that the complement components are not passively bound to the amyloid plaque structures but are the result of an activation process. The role of complement activation in the genesis of senile plaques is discussed.
      datePublished:
      dateModified:
      pageStart:259
      pageEnd:262
      sameAs:https://doi.org/10.1007/BF02890024
      keywords:
         Alzheimer’s dementia
         Amyloid plaques
         Complement activation
         Pathology
         Cell Biology
      image:
      isPartOf:
         name:Virchows Archiv B
         issn:
            0340-6075
         volumeNumber:56
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:P. Eikelenboom
            affiliation:
                  name:Free University
                  address:
                     name:Department of Psychiatry, Free University, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:C. E. Hack
            affiliation:
                  name:University of Amsterdam
                  address:
                     name:Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. M. Rozemuller
            affiliation:
                  name:Free University
                  address:
                     name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:F. C. Stam
            affiliation:
                  name:Free University
                  address:
                     name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Virchows Archiv B
      issn:
         0340-6075
      volumeNumber:56
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Free University
      address:
         name:Department of Psychiatry, Free University, Amsterdam, The Netherlands
         type:PostalAddress
      name:University of Amsterdam
      address:
         name:Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
         type:PostalAddress
      name:Free University
      address:
         name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
         type:PostalAddress
      name:Free University
      address:
         name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:P. Eikelenboom
      affiliation:
            name:Free University
            address:
               name:Department of Psychiatry, Free University, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:C. E. Hack
      affiliation:
            name:University of Amsterdam
            address:
               name:Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:J. M. Rozemuller
      affiliation:
            name:Free University
            address:
               name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:F. C. Stam
      affiliation:
            name:Free University
            address:
               name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Psychiatry, Free University, Amsterdam, The Netherlands
      name:Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
      name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
      name:Department of Neuropathology, Medical Faculty, Free University, Amsterdam, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(81)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.12s.

LINK . SPRINGER . COM {}