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Title:
Expression of the CD15 antigen (Lewis x) in breast cancer | Journal of Molecular Histology
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The expression of the cell adhesion molecule CD15 (also known as Lewis x) by breast cancers and by adjacent normal and benign breast epithelium was investigated in a series of 98 tumours. Immunohistochemistry was performed on paraffin sections using the anti-CD15 monoclonal mouse IgM antibody Dako-M1. Some 35% of cancers expressed CD15, as did 45% of normal and 60% of hyperplasia. No association was observed between cancer cell staining, or any epithelial staining (cancer, benign and normal), and tumour size, histological grade, nodal status, age at diagnosis or the frequency of โeventsโ (recurrence or death). Chi-squared tests in each case were non-significant. The pattern of CD15 expression by breast cancer was frequently associated with the leading edge of invading tumour or with the outer edge of boli of carcinomain situ, possibly suggesting a potential role in invasiveness, and with cancer cells trapped intravascularly, possibly suggesting a role in metastasis.
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month download article/chapter nodal status trisaccharide 3-fucosyl-n-acetyllactosamine 3-fucosyl-n-acetyl-lactosamine cancer cell staining breast cancer cells cancers expressed cd15 histological grade abo/lewis-related antigens breast cancer patients breast cancers full article pdf related carbohydrate antigens monoclonal antibodies vep8 privacy choices/manage cookies international histological classification breast cancer blood group substances benign breast epithelium human colorectal carcinoma human bone marrow mouse colon carcinoma check access instant access related subjects peripheral blood granulocytes cd15 differentiation antigen histochemical journal aims adhesion molecules /ley/leb antigens european economic area chi-squared tests conditions privacy policy tumour size invading tumour accepting optional cookies cell biochem usage analysis lung journal finder publish breast carcinoma cancer inst cancer res cancer 29a main content log histological typing cd15 expression article brooks article log breast tumours
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headline:Expression of the CD15 antigen (Lewis x) in breast cancer
description:The expression of the cell adhesion molecule CD15 (also known as Lewis x) by breast cancers and by adjacent normal and benign breast epithelium was investigated in a series of 98 tumours. Immunohistochemistry was performed on paraffin sections using the anti-CD15 monoclonal mouse IgM antibody Dako-M1. Some 35% of cancers expressed CD15, as did 45% of normal and 60% of hyperplasia. No association was observed between cancer cell staining, or any epithelial staining (cancer, benign and normal), and tumour size, histological grade, nodal status, age at diagnosis or the frequency of โeventsโ (recurrence or death). Chi-squared tests in each case were non-significant. The pattern of CD15 expression by breast cancer was frequently associated with the leading edge of invading tumour or with the outer edge of boli of carcinomain situ, possibly suggesting a potential role in invasiveness, and with cancer cells trapped intravascularly, possibly suggesting a role in metastasis.
datePublished:
dateModified:
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sameAs:https://doi.org/10.1007/BF02388541
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Breast Cancer
CD15 Expression
Nodal Status
Histological Grade
Cell Adhesion Molecule
Cell Biology
Biomedicine
general
Developmental Biology
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headline:Expression of the CD15 antigen (Lewis x) in breast cancer
description:The expression of the cell adhesion molecule CD15 (also known as Lewis x) by breast cancers and by adjacent normal and benign breast epithelium was investigated in a series of 98 tumours. Immunohistochemistry was performed on paraffin sections using the anti-CD15 monoclonal mouse IgM antibody Dako-M1. Some 35% of cancers expressed CD15, as did 45% of normal and 60% of hyperplasia. No association was observed between cancer cell staining, or any epithelial staining (cancer, benign and normal), and tumour size, histological grade, nodal status, age at diagnosis or the frequency of โeventsโ (recurrence or death). Chi-squared tests in each case were non-significant. The pattern of CD15 expression by breast cancer was frequently associated with the leading edge of invading tumour or with the outer edge of boli of carcinomain situ, possibly suggesting a potential role in invasiveness, and with cancer cells trapped intravascularly, possibly suggesting a role in metastasis.
datePublished:
dateModified:
pageStart:689
pageEnd:693
sameAs:https://doi.org/10.1007/BF02388541
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Breast Cancer
CD15 Expression
Nodal Status
Histological Grade
Cell Adhesion Molecule
Cell Biology
Biomedicine
general
Developmental Biology
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