We are analyzing https://link.springer.com/article/10.1007/bf02207276.

Title:
Thermogenesis in brown adipose tissue with age: Post-receptor activation by forskolin | Pflügers Archiv - European Journal of Physiology
Description:
β 3-Adrenergic-stimulated thermogenesis in brown adipose tissue (BAT) is diminished with age.β 3-Adrenergic receptors are positively coupled to adenylyl cyclase in BAT. To determine whether thermogenesis, in response to direct activation of adenylyl cyclase, is also impaired with age, we examined whole body oxygen consumption, mitochondrial guanosine diphosphate (GDP) binding and BAT mitochondrial uncoupling protein (UPC) mRNA levels in 4- and 24-month-old F-344 rats following forskolin administration. We also examined the forskolin-induced change in body temperature in 4-month-old rats. In some instances, the results were compared with administration of the specificβ 3-adrenergic agonist, CGP-12177. Forskolin (3.5 mg/kg) increased oxygen consumption but decreased body temperature. In subsequent experiments the BAT was unilaterally denervated. In these rats, the forskolin-(1.8 mg/kg) stimulated increase in oxygen consumption was similar in young and old rats. Forskolin increased GDP binding and UCP mRNA levels in both the denervated and innervated BAT pads. The increases were equal or greater in the BAT from senescent rats. These findings, coupled with our previous report of an impaired CGP-12177-stimulated increase in GDP binding in senescent rats, suggestsβ 3-adrenergic-stimulated, but not post-receptor-stimulated, thermogenesis is diminished with age.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter isoproterenol byβ-adrenergic antagonists impaired cgp-12177-stimulated increase β 3-adrenergic receptors specificβ 3-adrenergic agonist agonist cgp-12177a beta-adrenergic receptors protein phosphorylation research ageing energy metabolism privacy choices/manage cookies atypicalβ-adrenergic receptors adenylate cyclase activity related subjects full article pdf uncoupling protein expression suggestsβ 3-adrenergic-stimulated recent basic research adenylyl cyclase brown adipose tissue f-344 rats post-receptor-stimulated norepinephrine-induced thermogenesis mitochondrial guanosine diphosphate european economic area dopamine receptor d1 increased oxygen consumption conditions privacy policy post-receptor activation scarpace pj mitochondrial gdp binding check access instant access decreased body temperature accepting optional cookies article scarpace body oxygen consumption ucp mrna levels post-maturational aging innervated bat pads scarpace rights main content log forskolin-induced change journal finder publish impaired febrile response cgp-12177a mixedβ 1/β 2 geriatric research stimulated increase article log adrenergic stimulation

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         headline:Thermogenesis in brown adipose tissue with age: Post-receptor activation by forskolin
         description: β 3-Adrenergic-stimulated thermogenesis in brown adipose tissue (BAT) is diminished with age.β 3-Adrenergic receptors are positively coupled to adenylyl cyclase in BAT. To determine whether thermogenesis, in response to direct activation of adenylyl cyclase, is also impaired with age, we examined whole body oxygen consumption, mitochondrial guanosine diphosphate (GDP) binding and BAT mitochondrial uncoupling protein (UPC) mRNA levels in 4- and 24-month-old F-344 rats following forskolin administration. We also examined the forskolin-induced change in body temperature in 4-month-old rats. In some instances, the results were compared with administration of the specificβ 3-adrenergic agonist, CGP-12177. Forskolin (3.5 mg/kg) increased oxygen consumption but decreased body temperature. In subsequent experiments the BAT was unilaterally denervated. In these rats, the forskolin-(1.8 mg/kg) stimulated increase in oxygen consumption was similar in young and old rats. Forskolin increased GDP binding and UCP mRNA levels in both the denervated and innervated BAT pads. The increases were equal or greater in the BAT from senescent rats. These findings, coupled with our previous report of an impaired CGP-12177-stimulated increase in GDP binding in senescent rats, suggestsβ 3-adrenergic-stimulated, but not post-receptor-stimulated, thermogenesis is diminished with age.
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      headline:Thermogenesis in brown adipose tissue with age: Post-receptor activation by forskolin
      description: β 3-Adrenergic-stimulated thermogenesis in brown adipose tissue (BAT) is diminished with age.β 3-Adrenergic receptors are positively coupled to adenylyl cyclase in BAT. To determine whether thermogenesis, in response to direct activation of adenylyl cyclase, is also impaired with age, we examined whole body oxygen consumption, mitochondrial guanosine diphosphate (GDP) binding and BAT mitochondrial uncoupling protein (UPC) mRNA levels in 4- and 24-month-old F-344 rats following forskolin administration. We also examined the forskolin-induced change in body temperature in 4-month-old rats. In some instances, the results were compared with administration of the specificβ 3-adrenergic agonist, CGP-12177. Forskolin (3.5 mg/kg) increased oxygen consumption but decreased body temperature. In subsequent experiments the BAT was unilaterally denervated. In these rats, the forskolin-(1.8 mg/kg) stimulated increase in oxygen consumption was similar in young and old rats. Forskolin increased GDP binding and UCP mRNA levels in both the denervated and innervated BAT pads. The increases were equal or greater in the BAT from senescent rats. These findings, coupled with our previous report of an impaired CGP-12177-stimulated increase in GDP binding in senescent rats, suggestsβ 3-adrenergic-stimulated, but not post-receptor-stimulated, thermogenesis is diminished with age.
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         Molecular Medicine
         Neurosciences
         Cell Biology
         Receptors
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