We are analyzing https://link.springer.com/article/10.1007/bf01907051.

Title:
Developmental profiles of protective mechanisms of heart against peroxidative injury | Basic Research in Cardiology
Description:
The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8–10 day age group compared to that either by newborn or adult age groups. The four principal antioxidative enzymes, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase (G6PD), were enhanced during early neonatal growth and, with the exception of G6PD, all other enzymes were further enhanced during further growth to adulthood. G6PD activity dropped significantly in adult heart. The phospholipid contents of myocardial membrane between newborn and week-old pigs did not vary significantly. Total phospholipids and phosphatidylcholine contents were significantly higher in adult heart compared to those in neonatal heart. The enzymes of phospholipid synthesis and degradation, fatty acyl CoA synthetase (FACS), phospholipase A2 (PLA2), lysophospholipase (LPL), and lysophosphatidylcholine acyltransferase (LPCAT) increased during carly neonatal growth. During further growth to adulthood, FACS decreased, PLA2 did not change, whereas both LPL and LPCAT increased significantly. Analysis of free fatty acids showed that palmitic and stearic acids decreased during the first week of growth, but increased during further growth to adulthood. Oleic acid did not change with aging, but arachidonic acid dropped in adult heart compared to that in neonatal heart. Linoleic, palmitoleic and free fatty acids increased dramatically during the first week of neonatal growth, but dropped thereafter. These results suggest that the unusual peroxidative status of the week-old pig heart is related to the presence of high concentrations of polyunsaturated fatty acids in the membrane phospholipids and not with the antioxidative defense system.
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Keywords {🔍}

google, scholar, pubmed, heart, fatty, lipid, article, peroxidation, acids, res, engelman, neonatal, growth, myocardial, biol, injury, otani, rousou, breyer, superoxide, rat, basic, adult, free, acid, physiol, lung, cardiol, privacy, cookies, content, research, enzymes, phospholipids, increased, lipids, chem, circ, biochem, biophys, effect, publish, search, protective, mechanisms, peroxidative, flansaas, age, newborn, dismutase,

Topics {✒️}

free fatty acids polyunsaturated fatty acids month download article/chapter α-adrenergic receptor numbers oxygen free-radical scavengers myocardial high-energy phosphates high-performance liquid chromatography fatty acids article basic research stearic acids decreased free radical scavengers pentose pathway privacy choices/manage cookies lipid peroxidation expressed lipid-peroxidation processes principal antioxidative enzymes lysolecithin hydrolyzing enzymes myocardial injury induced lipid peroxidation damage thiobarbituric acid reaction full article pdf glucose-6-phosphate dehydrogenase plasma lipids perturbed unesterified arachidonic acid check access enzymatic protective mechanism myocardial enzyme release instant access total phospholipids membrane phospholipids european economic area scope submit manuscript arachidonic acid dropped unusual peroxidative status sloan-stanley gh folin phenol reagent elsevier/north holland conditions privacy policy related subjects antioxidative defense system adult heart compared ischemic canine myocardium lipid peroxidation neonatal mammalian heart adult age groups accepting optional cookies glutathione peroxidase activity ozone-exposed rats 1-acylglycerophosphonylcholine acyltransferase system lpcat increased significantly

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         headline:Developmental profiles of protective mechanisms of heart against peroxidative injury
         description:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8–10 day age group compared to that either by newborn or adult age groups. The four principal antioxidative enzymes, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase (G6PD), were enhanced during early neonatal growth and, with the exception of G6PD, all other enzymes were further enhanced during further growth to adulthood. G6PD activity dropped significantly in adult heart. The phospholipid contents of myocardial membrane between newborn and week-old pigs did not vary significantly. Total phospholipids and phosphatidylcholine contents were significantly higher in adult heart compared to those in neonatal heart. The enzymes of phospholipid synthesis and degradation, fatty acyl CoA synthetase (FACS), phospholipase A2 (PLA2), lysophospholipase (LPL), and lysophosphatidylcholine acyltransferase (LPCAT) increased during carly neonatal growth. During further growth to adulthood, FACS decreased, PLA2 did not change, whereas both LPL and LPCAT increased significantly. Analysis of free fatty acids showed that palmitic and stearic acids decreased during the first week of growth, but increased during further growth to adulthood. Oleic acid did not change with aging, but arachidonic acid dropped in adult heart compared to that in neonatal heart. Linoleic, palmitoleic and free fatty acids increased dramatically during the first week of neonatal growth, but dropped thereafter. These results suggest that the unusual peroxidative status of the week-old pig heart is related to the presence of high concentrations of polyunsaturated fatty acids in the membrane phospholipids and not with the antioxidative defense system.
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      headline:Developmental profiles of protective mechanisms of heart against peroxidative injury
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