We are analyzing https://link.springer.com/article/10.1007/bf01833517.

Title:
Influence of age and parity on the development of the human breast | Breast Cancer Research and Treatment
Description:
Breast cancer is heavily influenced by the reproductive history of the individual. Pregnancy has a protective effect which is attributed to differences in the degree of differentiation of the breast. The purpose of this work was to determine whether the quantity and the type of parenchymal structures present in the human breast were related to the age and parity history of a woman. Fifty-one human breast samples were obtained from bilateral or unilateral reduction mammoplasties performed in 40 parous women ranging in age from 18 to 57 years, and 11 nulliparous women ranging in age from 14 to 54 years. An average of 100 grams of tissue/specimen were processed for whole mount. A total of 650 slides were examined and 31,222 structures were classified and counted under the light microscope. The following mammary structures were identified: terminal structures (TS), and lobules (LOB) type 1, 2, and 3. Results were plotted for the total patient population and separately for nulliparous and parous women against age. The total patient population contained similar proportions of Lobl, 2, and 3 between ages 14–18, with a reduction of percentage of Lobl and increase in Lob3 between ages 23 to the middle forties, when Lob3 decreased and Lobl increased to 70%. Lob2 and TS did not exhibit significant changes throughout the period of life analyzed. When analyzed separately it was found that the breasts of nulliparous women were predominantly composed of Lob1, fewer Lob2, with Lob3 almost completely absent, whereas parous women had a high frequency of Lob3, which were the predominant structures until the fourth decade of life. Thereafter, their number decreased, with a concomitant increase in Lob1. These changes resulted in a similar appearance in the architecture of the breast of parous and nulliparous women after the fifth decade of life. It was concluded that there are striking differences in the developmental pattern of the breast between nulliparous and parous women.
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Keywords {🔍}

russo, breast, google, scholar, cancer, human, pubmed, mammary, article, age, gland, development, lob, influence, parous, women, nulliparous, access, susceptibility, carcinogenesis, rat, natl, inst, privacy, cookies, content, research, parity, differentiation, structures, publish, search, reproductive, pregnancy, related, life, normal, open, study, york, lactation, vitro, res, macmahon, pathol, cell, data, information, log, journal,

Topics {✒️}

month download article/chapter total patient population privacy choices/manage cookies full article pdf human breast development normal human breast human breast samples human breast cancer related subjects human chorionic gonadotropin breast cancer prevention nulliparous breast tissues rat mammary tumorigenesis preoperative breast biopsies breast cancer patients experimental breast cancer human mammary gland european economic area scope submit manuscript classical lobular neoplasia swiss working group dna labeling index rat mammary gland breast cancer risk conditions privacy policy check access instant access van zwieten mj adult healthy parous accepting optional cookies parenchymal structures present defining morphologic parameters oral contraceptive hormones journal finder publish article russo early reproductive life valaoras vg human breast russo rights article log breast cancer springer-verlag similar content cancer res 48 cancer res 40 article cite mammary cancer privacy policy personal data normal parous

Questions {❓}

Russo J, Russo IH: Is differentiation the answer to breast cancer prevention?

Schema {🗺️}

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         headline:Influence of age and parity on the development of the human breast
         description:Breast cancer is heavily influenced by the reproductive history of the individual. Pregnancy has a protective effect which is attributed to differences in the degree of differentiation of the breast. The purpose of this work was to determine whether the quantity and the type of parenchymal structures present in the human breast were related to the age and parity history of a woman. Fifty-one human breast samples were obtained from bilateral or unilateral reduction mammoplasties performed in 40 parous women ranging in age from 18 to 57 years, and 11 nulliparous women ranging in age from 14 to 54 years. An average of 100 grams of tissue/specimen were processed for whole mount. A total of 650 slides were examined and 31,222 structures were classified and counted under the light microscope. The following mammary structures were identified: terminal structures (TS), and lobules (LOB) type 1, 2, and 3. Results were plotted for the total patient population and separately for nulliparous and parous women against age. The total patient population contained similar proportions of Lobl, 2, and 3 between ages 14–18, with a reduction of percentage of Lobl and increase in Lob3 between ages 23 to the middle forties, when Lob3 decreased and Lobl increased to 70%. Lob2 and TS did not exhibit significant changes throughout the period of life analyzed. When analyzed separately it was found that the breasts of nulliparous women were predominantly composed of Lob1, fewer Lob2, with Lob3 almost completely absent, whereas parous women had a high frequency of Lob3, which were the predominant structures until the fourth decade of life. Thereafter, their number decreased, with a concomitant increase in Lob1. These changes resulted in a similar appearance in the architecture of the breast of parous and nulliparous women after the fifth decade of life. It was concluded that there are striking differences in the developmental pattern of the breast between nulliparous and parous women.
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