We are analyzing https://link.springer.com/article/10.1007/bf01816434.

Title:
Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis | Rheumatology International
Description:
Objective. To investigate the effects of desferrioxamine (DFO) infusion on chronic disease anemia (CDA) of rheumatoid arthritis (RA) by evaluating interleukin-6 (IL-6) and erythropoietin (EPO) production.Patients and methods. Five patients with RA and CDA (group I) were treated with DFO, 500 mg daily, through a continuous 10-h subcutaneous infusion 5 days a week for 4 weeks. One month after withdrawal, DFO was resumed in all five group I patients (group II) with an increase to 1 g daily following the previous treatment schedule. Clinical and laboratory parameters were evaluated weekly during the two study periods. Serum EPO was measured by radioimmunoassay. IL-6 was detected by the enzyme-linked immunoabsorbent assay method.Results. No significant variations in hematological parameters, IL-6 or EPO levels were observed in group I patients. After 1 week of DFO 1 g daily, reticulocyte counts and EPO improved significantly. Hemoglobin and hematocrit rose significantly after 3 weeks of 1 g daily DFO therapy. Four weeks after DFO withdrawal, EPO, reticulocyte counts, hemoglobin and hematocrit returned to baseline levels. A significant improvement in the clinical parameters of disease activity was observed, particularly in group II patients.Conclusion. DFO improves CDA in RA patients. The beneficial effects on erythropoiesis seem to be related to improved EPO responsiveness to the anemia.
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arthritis, rheumatoid, google, scholar, article, pubmed, erythropoietin, desferrioxamine, disease, anemia, effects, dfo, chronic, epo, access, iron, anaemia, rheumatol, privacy, cookies, content, therapy, salvarani, lasagni, patients, group, daily, treatment, clinical, publish, search, macchioni, portioli, interleukin, italy, analysis, data, information, log, journal, research, rheumatology, baricchi, boiardi, brunati, cda, weeks, month, laboratory, parameters,

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month download article/chapter ospedale niguarda ca'granda potential anti-inflammatory activity hypoxia-induced erythropoietin production azienda ospedaliera arcispedale chronic disease anemia full article pdf privacy choices/manage cookies recombinant human erythropoietin hypoxia signal transduction impaired erythropoietin responsiveness blunted erythropoietin response ocular toxicity induced check access instant access iron deficiency anemia daily dfo therapy european economic area scope submit manuscript repository corticotropin injection van eijk hg medsger ta jr conditions privacy policy chronic disease hematocrit rose significantly nuova reggio emilia accepting optional cookies june 1996 volume 16 epo improved significantly disease activity improved epo responsiveness inferiority trial related subjects desferrioxamine therapy rheumatoid arthritis previous treatment schedule journal finder publish article salvarani article log usage analysis laboratory analysis arthritis rheum 31 dfo improves cda article cite evaluating interleukin-6 oral chelator 1 systemic disease reggio emilia privacy policy personal data

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         headline:Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis
         description: Objective. To investigate the effects of desferrioxamine (DFO) infusion on chronic disease anemia (CDA) of rheumatoid arthritis (RA) by evaluating interleukin-6 (IL-6) and erythropoietin (EPO) production.Patients and methods. Five patients with RA and CDA (group I) were treated with DFO, 500 mg daily, through a continuous 10-h subcutaneous infusion 5 days a week for 4 weeks. One month after withdrawal, DFO was resumed in all five group I patients (group II) with an increase to 1 g daily following the previous treatment schedule. Clinical and laboratory parameters were evaluated weekly during the two study periods. Serum EPO was measured by radioimmunoassay. IL-6 was detected by the enzyme-linked immunoabsorbent assay method.Results. No significant variations in hematological parameters, IL-6 or EPO levels were observed in group I patients. After 1 week of DFO 1 g daily, reticulocyte counts and EPO improved significantly. Hemoglobin and hematocrit rose significantly after 3 weeks of 1 g daily DFO therapy. Four weeks after DFO withdrawal, EPO, reticulocyte counts, hemoglobin and hematocrit returned to baseline levels. A significant improvement in the clinical parameters of disease activity was observed, particularly in group II patients.Conclusion. DFO improves CDA in RA patients. The beneficial effects on erythropoiesis seem to be related to improved EPO responsiveness to the anemia.
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      headline:Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis
      description: Objective. To investigate the effects of desferrioxamine (DFO) infusion on chronic disease anemia (CDA) of rheumatoid arthritis (RA) by evaluating interleukin-6 (IL-6) and erythropoietin (EPO) production.Patients and methods. Five patients with RA and CDA (group I) were treated with DFO, 500 mg daily, through a continuous 10-h subcutaneous infusion 5 days a week for 4 weeks. One month after withdrawal, DFO was resumed in all five group I patients (group II) with an increase to 1 g daily following the previous treatment schedule. Clinical and laboratory parameters were evaluated weekly during the two study periods. Serum EPO was measured by radioimmunoassay. IL-6 was detected by the enzyme-linked immunoabsorbent assay method.Results. No significant variations in hematological parameters, IL-6 or EPO levels were observed in group I patients. After 1 week of DFO 1 g daily, reticulocyte counts and EPO improved significantly. Hemoglobin and hematocrit rose significantly after 3 weeks of 1 g daily DFO therapy. Four weeks after DFO withdrawal, EPO, reticulocyte counts, hemoglobin and hematocrit returned to baseline levels. A significant improvement in the clinical parameters of disease activity was observed, particularly in group II patients.Conclusion. DFO improves CDA in RA patients. The beneficial effects on erythropoiesis seem to be related to improved EPO responsiveness to the anemia.
      datePublished:
      dateModified:
      pageStart:45
      pageEnd:48
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         Chronic disease anemia
         Rheumatoid arthritis
         Erythropoietin
         Interleukin-6
         Rheumatology
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