We are analyzing https://link.springer.com/article/10.1007/bf01807035.

Title:
IGF-II mRNA and protein are expressed in the stroma of invasive breast cancers: Anin situ hybridization and immunohistochemistry study | Breast Cancer Research and Treatment
Description:
Insulin-like growth factor-II (IGF-II) is a potent mitogen for a variety of cell types and is considered an important regulator of breast cancer growth. In this study, we analyzed IGF-II mRNA and protein expression in a series of 80 cases of invasive breast cancer. Seventy-five cases produced informative results for IGF-II mRNA expression, and were scored on an arbitrary scale. Two cases (2.6%) had no significant IGF-II mRNA expression. 35 cases (46.7%) expressed low levels of IGF-II mRNA, 20 cases (26.7%) moderate IGF-II mRNA, while 18 (24%) expressed high levels of IGF-II message. Generally, IGF-II mRNA was expressed in the smooth muscle walls of blood vessels and ducts, as well as in the stroma tightly adjacent to and surrounding tumor epithelium. IGF-II mRNA content was also directly related to the amount of the stroma within the tumor (p<0.05). In 10 cases (13.3%) IGF-II mRNA was detected in the stroma of normal lobules. Fifty-six out of 75 were positive for IGF-II immunostaining. Again, protein staining was generally observed in the smooth muscle of both blood vessels and ducts, as well as in the stroma surrounding tumor epithelium. In normal lobules and ducts the IGF-II protein was detected in the myoepithelium. Unequivocal IGF-II protein staining was seen in tumor epithelium in only three cases. The results of our study demonstrate that, in breast cancer, IGF-II mRNA is expressed in the smooth muscle and stromal components in the majority of invasive breast cancers. IGF-II expression correlates positively with the amount of stromal tissue present within a tumor. This suggests that IGF-II may have an important growth regulatory effect on breast tumor epithelium through paracrine pathways.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Social Networks

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

breast, cancer, growth, google, scholar, igfii, pubmed, factor, insulinlike, expression, human, mrna, res, cullen, article, lippman, stroma, cell, cases, fibroblasts, research, protein, expressed, tumor, epithelium, rosen, privacy, cookies, content, situ, hybridization, publish, search, invasive, study, giani, campani, smooth, muscle, tissue, access, gene, malignant, cells, paik, sci, usa, skin, pisa, analysis,

Topics {✒️}

growth factor-ii overexpression month download article/chapter igf-ii mrna expression analyzed igf-ii mrna moderate igf-ii mrna igf-ii mrna content growth factor expression growth factor-ii situ hybridization access gene expression anin situ hybridization privacy choices/manage cookies igf-ii mrna human breast cancer breast cancer growth human breast fibroblasts human fetal fibroblasts growth-promoting activity igf-ii message igf-ii immunostaining breast cancer epithelium invasive breast cancer full article pdf growth-deficiency phenotype invasive breast cancers ductal infiltrating carcinoma igf-ii protein european economic area axillary node status von eschenbach ac heterozygous mice carrying van roozendaal kep skin fibroblasts obtained breast tumor epithelium surrounding tumor epithelium malignant breast epithelium conditions privacy policy malignant breast tissue growth factor accepting optional cookies stromal tissue present smooth muscle walls smooth muscle differentiation stroma tightly adjacent expressed low levels expressed high levels longterm tissue culture journal finder publish igf-ii article giani

Schema {🗺️}

WebPage:
      mainEntity:
         headline:IGF-II mRNA and protein are expressed in the stroma of invasive breast cancers: Anin situ hybridization and immunohistochemistry study
         description:Insulin-like growth factor-II (IGF-II) is a potent mitogen for a variety of cell types and is considered an important regulator of breast cancer growth. In this study, we analyzed IGF-II mRNA and protein expression in a series of 80 cases of invasive breast cancer. Seventy-five cases produced informative results for IGF-II mRNA expression, and were scored on an arbitrary scale. Two cases (2.6%) had no significant IGF-II mRNA expression. 35 cases (46.7%) expressed low levels of IGF-II mRNA, 20 cases (26.7%) moderate IGF-II mRNA, while 18 (24%) expressed high levels of IGF-II message. Generally, IGF-II mRNA was expressed in the smooth muscle walls of blood vessels and ducts, as well as in the stroma tightly adjacent to and surrounding tumor epithelium. IGF-II mRNA content was also directly related to the amount of the stroma within the tumor (p<0.05). In 10 cases (13.3%) IGF-II mRNA was detected in the stroma of normal lobules. Fifty-six out of 75 were positive for IGF-II immunostaining. Again, protein staining was generally observed in the smooth muscle of both blood vessels and ducts, as well as in the stroma surrounding tumor epithelium. In normal lobules and ducts the IGF-II protein was detected in the myoepithelium. Unequivocal IGF-II protein staining was seen in tumor epithelium in only three cases. The results of our study demonstrate that, in breast cancer, IGF-II mRNA is expressed in the smooth muscle and stromal components in the majority of invasive breast cancers. IGF-II expression correlates positively with the amount of stromal tissue present within a tumor. This suggests that IGF-II may have an important growth regulatory effect on breast tumor epithelium through paracrine pathways.
         datePublished:
         dateModified:
         pageStart:43
         pageEnd:50
         sameAs:https://doi.org/10.1007/BF01807035
         keywords:
            IGF-II
            breast cancer
            immunohistochemistry
             in situ hybridization
            Oncology
         image:
         isPartOf:
            name:Breast Cancer Research and Treatment
            issn:
               1573-7217
               0167-6806
            volumeNumber:41
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Kluwer Academic Publishers
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Claudio Giani
               affiliation:
                     name:University of Pisa
                     address:
                        name:Institute of Endocrinology, University of Pisa, Pisa, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kevin J. Cullen
               affiliation:
                     name:Georgetown University Medical Center
                     address:
                        name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniela Campani
               affiliation:
                     name:University of Pisa
                     address:
                        name:Institute of Pathology, University of Pisa, Pisa, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Audrey Rasmussen
               affiliation:
                     name:Georgetown University Medical Center
                     address:
                        name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:IGF-II mRNA and protein are expressed in the stroma of invasive breast cancers: Anin situ hybridization and immunohistochemistry study
      description:Insulin-like growth factor-II (IGF-II) is a potent mitogen for a variety of cell types and is considered an important regulator of breast cancer growth. In this study, we analyzed IGF-II mRNA and protein expression in a series of 80 cases of invasive breast cancer. Seventy-five cases produced informative results for IGF-II mRNA expression, and were scored on an arbitrary scale. Two cases (2.6%) had no significant IGF-II mRNA expression. 35 cases (46.7%) expressed low levels of IGF-II mRNA, 20 cases (26.7%) moderate IGF-II mRNA, while 18 (24%) expressed high levels of IGF-II message. Generally, IGF-II mRNA was expressed in the smooth muscle walls of blood vessels and ducts, as well as in the stroma tightly adjacent to and surrounding tumor epithelium. IGF-II mRNA content was also directly related to the amount of the stroma within the tumor (p<0.05). In 10 cases (13.3%) IGF-II mRNA was detected in the stroma of normal lobules. Fifty-six out of 75 were positive for IGF-II immunostaining. Again, protein staining was generally observed in the smooth muscle of both blood vessels and ducts, as well as in the stroma surrounding tumor epithelium. In normal lobules and ducts the IGF-II protein was detected in the myoepithelium. Unequivocal IGF-II protein staining was seen in tumor epithelium in only three cases. The results of our study demonstrate that, in breast cancer, IGF-II mRNA is expressed in the smooth muscle and stromal components in the majority of invasive breast cancers. IGF-II expression correlates positively with the amount of stromal tissue present within a tumor. This suggests that IGF-II may have an important growth regulatory effect on breast tumor epithelium through paracrine pathways.
      datePublished:
      dateModified:
      pageStart:43
      pageEnd:50
      sameAs:https://doi.org/10.1007/BF01807035
      keywords:
         IGF-II
         breast cancer
         immunohistochemistry
          in situ hybridization
         Oncology
      image:
      isPartOf:
         name:Breast Cancer Research and Treatment
         issn:
            1573-7217
            0167-6806
         volumeNumber:41
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Kluwer Academic Publishers
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Claudio Giani
            affiliation:
                  name:University of Pisa
                  address:
                     name:Institute of Endocrinology, University of Pisa, Pisa, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kevin J. Cullen
            affiliation:
                  name:Georgetown University Medical Center
                  address:
                     name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniela Campani
            affiliation:
                  name:University of Pisa
                  address:
                     name:Institute of Pathology, University of Pisa, Pisa, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Audrey Rasmussen
            affiliation:
                  name:Georgetown University Medical Center
                  address:
                     name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Breast Cancer Research and Treatment
      issn:
         1573-7217
         0167-6806
      volumeNumber:41
Organization:
      name:Kluwer Academic Publishers
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Pisa
      address:
         name:Institute of Endocrinology, University of Pisa, Pisa, Italy
         type:PostalAddress
      name:Georgetown University Medical Center
      address:
         name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
         type:PostalAddress
      name:University of Pisa
      address:
         name:Institute of Pathology, University of Pisa, Pisa, Italy
         type:PostalAddress
      name:Georgetown University Medical Center
      address:
         name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Claudio Giani
      affiliation:
            name:University of Pisa
            address:
               name:Institute of Endocrinology, University of Pisa, Pisa, Italy
               type:PostalAddress
            type:Organization
      name:Kevin J. Cullen
      affiliation:
            name:Georgetown University Medical Center
            address:
               name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
               type:PostalAddress
            type:Organization
      name:Daniela Campani
      affiliation:
            name:University of Pisa
            address:
               name:Institute of Pathology, University of Pisa, Pisa, Italy
               type:PostalAddress
            type:Organization
      name:Audrey Rasmussen
      affiliation:
            name:Georgetown University Medical Center
            address:
               name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Endocrinology, University of Pisa, Pisa, Italy
      name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
      name:Institute of Pathology, University of Pisa, Pisa, Italy
      name:Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(79)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.06s.

LINK . SPRINGER . COM {}