We are analyzing https://link.springer.com/article/10.1007/bf01806079.

Title:
Human breast cancer cell line xenografts as models of breast cancer — The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines | Breast Cancer Research and Treatment
Description:
The ability to maintain and study human tissues in anin vivo environment has proved to be a valuable tool in breast cancer research for several decades. The most widely studied tissues have been xenografts of established human breast cancer cell lines into athymic nude mice. Human breast tumor xenografts provide the opportunity to study various important interactions between the tumor and host tissues, including endocrinologic, immunologic, and tumor-stroma interactions. The nude mouse is not the only immune-deficient recipient system in which to study xenografts. Additional single and combined mutant strains have been used successfully, including mice homozygous for the severe combined immune deficiency mutation (scid), both the beige (bg) and nude (nu) mutations in combination (bg/nu), and mice bearing the combinedbg/nu/xid mutations. The differing immunobiologies are discussed, with particular reference to the immunobiology of breast cancer, as are the characteristics of several of the more frequently utilized breast cancer xenografts and cell lines. The ability of several endocrine treatments to modulate effectors of cell mediated immunity,e.g., estrogens and antiestrogens, and the effect of site of inoculation on tumor take and metastasis, also are described.
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Keywords {🔍}

google, scholar, cancer, pubmed, breast, human, cell, mice, cells, nude, res, growth, natural, killer, tumor, clarke, lippman, mouse, metastasis, immunol, mcf, lines, resistance, xenografts, athymic, combined, scid, tumors, brünner, dickson, exp, line, models, severe, characterization, activity, article, natl, receptor, med, factor, immunodeficiency, bosma, content, carcinoma, nature, metastatic, int, expression, antiestrogen,

Topics {✒️}

activated c-harasej/psv2neo genes x-linked b-lymphocyte defect x-linked immune-deficient mice month download article/chapter il-2-inducible killer cells lymphokine-activated killer cells tamoxifen-resistant breast cancer breast cancer patient natural cell-mediated immunity anti-pd-1-based therapy macrophage colony-stimulating factor rat mammary cells immune-deficient recipient system human cell line macrophage-mediated tumor cytolysis natural killer-deficient mice murine cell lines tumorigenic cell lines human tumour xenografts long-term antiestrogen administration long-term antiestrogen therapy human tumor xenografts breast cancer research autologous breast cancer congenitally immune-deficient mice rat mammary carcinomas oestrogen receptor expression human breast carcinoma human breast cancer combinedbg/nu/xid mutations increased basement membrane-invasiveness β-estradiol treatment human breast disease tamoxifen resistant variant tamoxifen-resistant variant natural killer cells human breast tumors xenograft ascites model b-lymphocyte heterogeneity murine tumor cells colon cancer cells human breast carcinomas cell mediated immunity molecular biology solitary tumors derived natural killer activity hormone-responsive variants breast cancer patients privacy choices/manage cookies ii-nu/nu mice

Schema {🗺️}

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         description:The ability to maintain and study human tissues in anin vivo environment has proved to be a valuable tool in breast cancer research for several decades. The most widely studied tissues have been xenografts of established human breast cancer cell lines into athymic nude mice. Human breast tumor xenografts provide the opportunity to study various important interactions between the tumor and host tissues, including endocrinologic, immunologic, and tumor-stroma interactions. The nude mouse is not the only immune-deficient recipient system in which to study xenografts. Additional single and combined mutant strains have been used successfully, including mice homozygous for the severe combined immune deficiency mutation (scid), both the beige (bg) and nude (nu) mutations in combination (bg/nu), and mice bearing the combinedbg/nu/xid mutations. The differing immunobiologies are discussed, with particular reference to the immunobiology of breast cancer, as are the characteristics of several of the more frequently utilized breast cancer xenografts and cell lines. The ability of several endocrine treatments to modulate effectors of cell mediated immunity,e.g., estrogens and antiestrogens, and the effect of site of inoculation on tumor take and metastasis, also are described.
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