We are analyzing https://link.springer.com/article/10.1007/bf01756134.

Title:
Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells | Cancer Immunology, Immunotherapy
Description:
Progressive growth of metastatic Lewis lung carcinoma (LLC) tumors results in a concurrent stimulation of myelopoiesis and the appearance of immune-suppressive bone marrow cells. The present study has shown that normal bone marrow cells could be induced to become immune-suppressive by 3 days of culture with supernatants of cloned metastatic LLC-LN7 variant cells. The capacity of the LLC-LN7 supernatants to stimulate the appearance of suppressor cells was directly proportional to the concentration of supernatant used in the bone marrow culture. When adoptively transferred with a LLC-LN7 tumor inoculum, the supernatant-induced suppressor bone marrow cells increased the rate of appearance of palpable tumors and the frequency of tumor establishment. The LLC-LN7 supernatants containing suppressor-cell-inducing activity also had colony-stimulating factor (CSF) activity. The CSF activity produced by the LLC-LN7 cells could be diminished with neutralizing antibodies to either granulocyte/monocyte(GM-) CSF or to interleukin-3 (IL-3). Likewise, the suppressor-inducing activity in the LLC-LN7 supernatants was diminished by pretreatment with anti-GM-CSF or anti-IL-3. The combination of anti-GM-CSF and anti-IL-3 completely neutralized all suppressor-inducing activity produced by the LLC-LN7 cells. These results suggest that the secretion of IL-3 and GM-CSF by LLC-LN7 tumor cells is a mechanism by which the tumors stimulate myelopoiesis and induce normal bone marrow cells to become immune-suppressive. Bone marrow cells that are induced to become immune-suppressive by culture with LLC-LN7 supernatants can, in turn, facilitate the establishment of tumor in vivo.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

google, scholar, cells, bone, marrow, young, factor, immunol, cancer, colonystimulating, suppressor, tumor, article, cell, carcinoma, llcln, human, lewis, res, lung, stimulation, immunesuppressive, activity, privacy, cookies, content, research, factors, wright, supernatants, macrophage, granulocytemacrophage, information, publish, search, metastatic, tumors, normal, culture, csf, vivo, access, murine, induction, data, log, journal, immunology, immunotherapy, antibodies,

Topics {✒️}

granulocyte-macrophage colony-stimulating factor macrophage colony-stimulating factor granulocyte colony-stimulating factor polyinosinic-polycytidylic acid-treated mice antigen-stimulated lymphocyte proliferation lewis lung carcinoma spleens of89sr-treated mice colony-stimulating factor month download article/chapter suppressor-cell-inducing activity colony-stimulating factors colony stimulating factors cyclophosphamide-resistant murine tumor l-leucine methyl ester article cancer immunology bone marrow cells suppressor-inducing activity produced high-dose recombinant interleukin-2 lymphokine-activated killer cells refractory metastatic carcinoma llc-ln7 tumor cells llc-ln7 tumor inoculum immune suppressor cells cyclophosphamide-facilitated adoptive immunotherapy spontaneous ifn-β production bone marrow versus human peripheral blood anti-il-3 completely neutralized human cell lines bone marrow culture suppressor cells found hemopoietic growth factors tumor-induced suppressor factor-mediated induction suppressor-inducing activity human myeloma cells normal human monocytes natural suppressor systems accessory cell llc-ln7 cells privacy choices/manage cookies bone marrow monocyte-mediated cytotoxicity promyelocytic cell line adherent mononuclear cell anti-gm-csf full article pdf murine mammary tumor granulocyte/monocyte csf activity produced

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells
         description:Progressive growth of metastatic Lewis lung carcinoma (LLC) tumors results in a concurrent stimulation of myelopoiesis and the appearance of immune-suppressive bone marrow cells. The present study has shown that normal bone marrow cells could be induced to become immune-suppressive by 3 days of culture with supernatants of cloned metastatic LLC-LN7 variant cells. The capacity of the LLC-LN7 supernatants to stimulate the appearance of suppressor cells was directly proportional to the concentration of supernatant used in the bone marrow culture. When adoptively transferred with a LLC-LN7 tumor inoculum, the supernatant-induced suppressor bone marrow cells increased the rate of appearance of palpable tumors and the frequency of tumor establishment. The LLC-LN7 supernatants containing suppressor-cell-inducing activity also had colony-stimulating factor (CSF) activity. The CSF activity produced by the LLC-LN7 cells could be diminished with neutralizing antibodies to either granulocyte/monocyte(GM-) CSF or to interleukin-3 (IL-3). Likewise, the suppressor-inducing activity in the LLC-LN7 supernatants was diminished by pretreatment with anti-GM-CSF or anti-IL-3. The combination of anti-GM-CSF and anti-IL-3 completely neutralized all suppressor-inducing activity produced by the LLC-LN7 cells. These results suggest that the secretion of IL-3 and GM-CSF by LLC-LN7 tumor cells is a mechanism by which the tumors stimulate myelopoiesis and induce normal bone marrow cells to become immune-suppressive. Bone marrow cells that are induced to become immune-suppressive by culture with LLC-LN7 supernatants can, in turn, facilitate the establishment of tumor in vivo.
         datePublished:
         dateModified:
         pageStart:146
         pageEnd:152
         sameAs:https://doi.org/10.1007/BF01756134
         keywords:
            Lewis lung carcinoma
            GM-CSF
            IL-3
            Bone marrow
            Immune suppressor
            Oncology
            Immunology
            Cancer Research
         image:
         isPartOf:
            name:Cancer Immunology, Immunotherapy
            issn:
               1432-0851
               0340-7004
            volumeNumber:33
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:M. Rita I. Young
               affiliation:
                     name:Hines V. A. Hospital
                     address:
                        name:Department of Research Services, Hines V. A. Hospital, Hines, USA
                        type:PostalAddress
                     type:Organization
                     name:Loyola University Stritch School of Medicine
                     address:
                        name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mark A. Wright
               affiliation:
                     name:Hines V. A. Hospital
                     address:
                        name:Department of Research Services, Hines V. A. Hospital, Hines, USA
                        type:PostalAddress
                     type:Organization
                     name:Loyola University Stritch School of Medicine
                     address:
                        name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Melvin E. Young
               affiliation:
                     name:Hines V. A. Hospital
                     address:
                        name:Department of Research Services, Hines V. A. Hospital, Hines, USA
                        type:PostalAddress
                     type:Organization
                     name:Loyola University Stritch School of Medicine
                     address:
                        name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells
      description:Progressive growth of metastatic Lewis lung carcinoma (LLC) tumors results in a concurrent stimulation of myelopoiesis and the appearance of immune-suppressive bone marrow cells. The present study has shown that normal bone marrow cells could be induced to become immune-suppressive by 3 days of culture with supernatants of cloned metastatic LLC-LN7 variant cells. The capacity of the LLC-LN7 supernatants to stimulate the appearance of suppressor cells was directly proportional to the concentration of supernatant used in the bone marrow culture. When adoptively transferred with a LLC-LN7 tumor inoculum, the supernatant-induced suppressor bone marrow cells increased the rate of appearance of palpable tumors and the frequency of tumor establishment. The LLC-LN7 supernatants containing suppressor-cell-inducing activity also had colony-stimulating factor (CSF) activity. The CSF activity produced by the LLC-LN7 cells could be diminished with neutralizing antibodies to either granulocyte/monocyte(GM-) CSF or to interleukin-3 (IL-3). Likewise, the suppressor-inducing activity in the LLC-LN7 supernatants was diminished by pretreatment with anti-GM-CSF or anti-IL-3. The combination of anti-GM-CSF and anti-IL-3 completely neutralized all suppressor-inducing activity produced by the LLC-LN7 cells. These results suggest that the secretion of IL-3 and GM-CSF by LLC-LN7 tumor cells is a mechanism by which the tumors stimulate myelopoiesis and induce normal bone marrow cells to become immune-suppressive. Bone marrow cells that are induced to become immune-suppressive by culture with LLC-LN7 supernatants can, in turn, facilitate the establishment of tumor in vivo.
      datePublished:
      dateModified:
      pageStart:146
      pageEnd:152
      sameAs:https://doi.org/10.1007/BF01756134
      keywords:
         Lewis lung carcinoma
         GM-CSF
         IL-3
         Bone marrow
         Immune suppressor
         Oncology
         Immunology
         Cancer Research
      image:
      isPartOf:
         name:Cancer Immunology, Immunotherapy
         issn:
            1432-0851
            0340-7004
         volumeNumber:33
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:M. Rita I. Young
            affiliation:
                  name:Hines V. A. Hospital
                  address:
                     name:Department of Research Services, Hines V. A. Hospital, Hines, USA
                     type:PostalAddress
                  type:Organization
                  name:Loyola University Stritch School of Medicine
                  address:
                     name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mark A. Wright
            affiliation:
                  name:Hines V. A. Hospital
                  address:
                     name:Department of Research Services, Hines V. A. Hospital, Hines, USA
                     type:PostalAddress
                  type:Organization
                  name:Loyola University Stritch School of Medicine
                  address:
                     name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Melvin E. Young
            affiliation:
                  name:Hines V. A. Hospital
                  address:
                     name:Department of Research Services, Hines V. A. Hospital, Hines, USA
                     type:PostalAddress
                  type:Organization
                  name:Loyola University Stritch School of Medicine
                  address:
                     name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer Immunology, Immunotherapy
      issn:
         1432-0851
         0340-7004
      volumeNumber:33
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Hines V. A. Hospital
      address:
         name:Department of Research Services, Hines V. A. Hospital, Hines, USA
         type:PostalAddress
      name:Loyola University Stritch School of Medicine
      address:
         name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
         type:PostalAddress
      name:Hines V. A. Hospital
      address:
         name:Department of Research Services, Hines V. A. Hospital, Hines, USA
         type:PostalAddress
      name:Loyola University Stritch School of Medicine
      address:
         name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
         type:PostalAddress
      name:Hines V. A. Hospital
      address:
         name:Department of Research Services, Hines V. A. Hospital, Hines, USA
         type:PostalAddress
      name:Loyola University Stritch School of Medicine
      address:
         name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:M. Rita I. Young
      affiliation:
            name:Hines V. A. Hospital
            address:
               name:Department of Research Services, Hines V. A. Hospital, Hines, USA
               type:PostalAddress
            type:Organization
            name:Loyola University Stritch School of Medicine
            address:
               name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
               type:PostalAddress
            type:Organization
      name:Mark A. Wright
      affiliation:
            name:Hines V. A. Hospital
            address:
               name:Department of Research Services, Hines V. A. Hospital, Hines, USA
               type:PostalAddress
            type:Organization
            name:Loyola University Stritch School of Medicine
            address:
               name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
               type:PostalAddress
            type:Organization
      name:Melvin E. Young
      affiliation:
            name:Hines V. A. Hospital
            address:
               name:Department of Research Services, Hines V. A. Hospital, Hines, USA
               type:PostalAddress
            type:Organization
            name:Loyola University Stritch School of Medicine
            address:
               name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Research Services, Hines V. A. Hospital, Hines, USA
      name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
      name:Department of Research Services, Hines V. A. Hospital, Hines, USA
      name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
      name:Department of Research Services, Hines V. A. Hospital, Hines, USA
      name:Department of Pathology, Loyola University Stritch School of Medicine, Maywood, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(61)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.24s.

LINK . SPRINGER . COM {}