We are analyzing https://link.springer.com/article/10.1007/bf01741049.

Title:
Tumor-derived cytokines induce bone marrow suppressor cells that mediate immunosuppression through transforming growth factor β | Cancer Immunology, Immunotherapy
Description:
Normal bone marrow cells become immunosuppressive when cultured with supernatants of metastatic Lewis lung carcinoma (LLC-LN7) cells. The suppressorinducing activities in the LLC-LN7 supernatants are interleukin-3 and granulocyte/macrophage-colony-stimulating factor. In the present study, the mechanisms by which these induced suppressor cells (LLCsup-BM) mediate their immunosuppression were investigated. The suppression by LLCsup-BM of splenic concanavalin CA blastogenesis was not dependent on cell contact since immunosuppression occurred regardless of whether the LLCsup-BM were separated from the responder spleen cells by a permeable membrane or if the LLCsup-BM were cocultured with the spleen cells. Culture supernatants of LLCsup-BM also inhibited T cell blastogenesis, being more suppressive than were supernatants of control bone marrow cells, which had been precultured with medium. The suppression by the soluble inhibitors elaborated from the LLCsup-BM was not restricted to the inhibition of T cell function as the supernatants also inhibited the natural killer activity of normal spleen cells. Studies to determine the identity of the suppressive activity produced by the LLCsup-BM showed increased levels of transforming growth factor β (TGFβ) in their supernatants. Immunosuppressive bone marrow and spleen cells obtained from mice bearing metastatic LLC-LN7 tumors also secreted more TGFβ than did the cells obtained from normal mice. When anti-TGFβ antibodies were added to the LLCsup-BM supernatants, the suppressive activity was diminished. These results suggest that the LLCsup-BM mediate at least part of their immunosuppression through production of TGFβ.
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Keywords {🔍}

google, scholar, cells, immunol, young, suppressor, transforming, growth, cell, bone, factor, article, marrow, cancer, activity, llcsupbm, mice, immunosuppression, lung, wright, supernatants, lewis, carcinoma, suppression, normal, suppressive, natural, killer, role, immune, factorβ, privacy, cookies, content, research, spleen, inhibition, production, access, murine, function, information, publish, search, mediate, coogan, tgfβ, bearing, regulation, tumor,

Topics {✒️}

tumor necrosis factor-alpha transforming growth factor-beta granulocyte/macrophage-colony-stimulating factor transforming growth factor-β transforming growth factor-β1 tumor-derived cytokines month download article/chapter lectin-activated cell proliferation cyclophosphamide-resistant murine tumor b16-f10l murine melanoma autologous melanoma-induced activation hematopoietic regulatory proteins lymphokine-activated killer activity spontaneous ifn-beta production bone marrow versus tumor-bearing state colony-stimulating factor suppressor cell activity induced suppressor cells immunosuppressive bone marrow colony stimulating factors tumor-bearing mice immune suppressor cells article cancer immunology natural suppressor systems factor-mediated induction suppressor factor privacy choices/manage cookies full article pdf macrophage-mediated immunosuppression bone marrow lymphokine-activated killer anti-tumor response natural killer activity macrophage-mediated suppression t-cells suppress cytotoxic response cell induction mediated suppressive activity produced recombinant interferon-alpha medical research services leukemic myeloid cells soluble inhibitors elaborated related subjects cytolytic effector response interferon induced inhibition llc-ln7 supernatants european economic area scope submit manuscript allopregnant mouse decidua

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         description:Normal bone marrow cells become immunosuppressive when cultured with supernatants of metastatic Lewis lung carcinoma (LLC-LN7) cells. The suppressorinducing activities in the LLC-LN7 supernatants are interleukin-3 and granulocyte/macrophage-colony-stimulating factor. In the present study, the mechanisms by which these induced suppressor cells (LLCsup-BM) mediate their immunosuppression were investigated. The suppression by LLCsup-BM of splenic concanavalin CA blastogenesis was not dependent on cell contact since immunosuppression occurred regardless of whether the LLCsup-BM were separated from the responder spleen cells by a permeable membrane or if the LLCsup-BM were cocultured with the spleen cells. Culture supernatants of LLCsup-BM also inhibited T cell blastogenesis, being more suppressive than were supernatants of control bone marrow cells, which had been precultured with medium. The suppression by the soluble inhibitors elaborated from the LLCsup-BM was not restricted to the inhibition of T cell function as the supernatants also inhibited the natural killer activity of normal spleen cells. Studies to determine the identity of the suppressive activity produced by the LLCsup-BM showed increased levels of transforming growth factor β (TGFβ) in their supernatants. Immunosuppressive bone marrow and spleen cells obtained from mice bearing metastatic LLC-LN7 tumors also secreted more TGFβ than did the cells obtained from normal mice. When anti-TGFβ antibodies were added to the LLCsup-BM supernatants, the suppressive activity was diminished. These results suggest that the LLCsup-BM mediate at least part of their immunosuppression through production of TGFβ.
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      description:Normal bone marrow cells become immunosuppressive when cultured with supernatants of metastatic Lewis lung carcinoma (LLC-LN7) cells. The suppressorinducing activities in the LLC-LN7 supernatants are interleukin-3 and granulocyte/macrophage-colony-stimulating factor. In the present study, the mechanisms by which these induced suppressor cells (LLCsup-BM) mediate their immunosuppression were investigated. The suppression by LLCsup-BM of splenic concanavalin CA blastogenesis was not dependent on cell contact since immunosuppression occurred regardless of whether the LLCsup-BM were separated from the responder spleen cells by a permeable membrane or if the LLCsup-BM were cocultured with the spleen cells. Culture supernatants of LLCsup-BM also inhibited T cell blastogenesis, being more suppressive than were supernatants of control bone marrow cells, which had been precultured with medium. The suppression by the soluble inhibitors elaborated from the LLCsup-BM was not restricted to the inhibition of T cell function as the supernatants also inhibited the natural killer activity of normal spleen cells. Studies to determine the identity of the suppressive activity produced by the LLCsup-BM showed increased levels of transforming growth factor β (TGFβ) in their supernatants. Immunosuppressive bone marrow and spleen cells obtained from mice bearing metastatic LLC-LN7 tumors also secreted more TGFβ than did the cells obtained from normal mice. When anti-TGFβ antibodies were added to the LLCsup-BM supernatants, the suppressive activity was diminished. These results suggest that the LLCsup-BM mediate at least part of their immunosuppression through production of TGFβ.
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