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Title:
The current status of REH theory | Journal of Molecular Evolution
Description:
The recent evaluation by Fitch (1980) of REH theory for macromolecular divergence is a severely erroneous and distorted analysis of our work over the past decade. We reply to those distortions here. At present, there is no factual basis for believing Fitch
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google, scholar, evolution, mol, holmquist, evol, evolutionary, jukes, molecular, proteins, protein, article, theory, reh, method, press, biol, analysis, fitch, genetic, genes, parsimony, model, york, stochastic, privacy, cookies, journal, research, divergence, mutations, goodman, maximum, nature, nucleotide, science, eds, acid, sequences, content, data, information, publish, search, estimates, events, access, structure, dayhoff, phylogenetic,
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month download article/chapter amino-acid sequnce investigations evolutionary biology move evolutionary estimates reh theory letters molecular evolution aims estimating evolutionary rates privacy choices/manage cookies quantitative evolutionary analysis humanΞ²-globin gene mammalian protein metabolism amino acid composition amino-acid composition beta hemoglobin mrnas maximum parsimony method nonuniform molecular divergence maximum entropy formalism molecular restoration studies protein structure full article pdf reh theory total mutations fixed european economic area determining codon variablity populous path algorithm molecular evolution conditions privacy policy evolutionary divergence specific tree topology additive similarity trees nucleic acid divergence check access instant access globin family genes accepting optional cookies comparing homologous sequences immunological distance data evolutionary implications evolutionary events rate-constancy hypothesis estimating superimposed mutations journal finder publish main content log evolutionary change increased variance sufficient homologous polypeptide chains protein sequences molecular divergence globin evolution selective structural constraints
Questions {β}
- Jaynes ET (1979) Where do we stand on maximum entropy?
- Kimura M (1981) Was globin evolution very rapid in its early stages?
- King JL (1980) Does the information density of amino acid composition increase?
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headline:The current status of REH theory
description:The recent evaluation by Fitch (1980) of REH theory for macromolecular divergence is a severely erroneous and distorted analysis of our work over the past decade. We reply to those distortions here. At present, there is no factual basis for believing Fitch's assessment that corrections which move evolutionary estimates of total mutations fixed closer to the true distance must do so at the expense of an increased variance sufficient to compromise the value of the improvement. By direct calculation the variance in the estimates of total mutations fixed given by REH theory is comparable to that of other models now in the literature for the case in which genetic events are equiprobable. A general argument is given that suggests that, as we consider more and more carefully the selective, functional, and structural constraints on the evolution of genes and proteins, this variance may be expected to decrease toward a lower bound.
datePublished:
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pageStart:47
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sameAs:https://doi.org/10.1007/BF01733211
keywords:
Gene evolution
Protein evolution
Molecular evolution
REH theory
Evolutionary estimates
Evolutionary Biology
Microbiology
Plant Sciences
Plant Genetics and Genomics
Animal Genetics and Genomics
Cell Biology
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headline:The current status of REH theory
description:The recent evaluation by Fitch (1980) of REH theory for macromolecular divergence is a severely erroneous and distorted analysis of our work over the past decade. We reply to those distortions here. At present, there is no factual basis for believing Fitch's assessment that corrections which move evolutionary estimates of total mutations fixed closer to the true distance must do so at the expense of an increased variance sufficient to compromise the value of the improvement. By direct calculation the variance in the estimates of total mutations fixed given by REH theory is comparable to that of other models now in the literature for the case in which genetic events are equiprobable. A general argument is given that suggests that, as we consider more and more carefully the selective, functional, and structural constraints on the evolution of genes and proteins, this variance may be expected to decrease toward a lower bound.
datePublished:
dateModified:
pageStart:47
pageEnd:59
sameAs:https://doi.org/10.1007/BF01733211
keywords:
Gene evolution
Protein evolution
Molecular evolution
REH theory
Evolutionary estimates
Evolutionary Biology
Microbiology
Plant Sciences
Plant Genetics and Genomics
Animal Genetics and Genomics
Cell Biology
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