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We are analyzing https://link.springer.com/article/10.1007/bf01733211.

Title:
The current status of REH theory | Journal of Molecular Evolution
Description:
The recent evaluation by Fitch (1980) of REH theory for macromolecular divergence is a severely erroneous and distorted analysis of our work over the past decade. We reply to those distortions here. At present, there is no factual basis for believing Fitch
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {πŸ“š}

  • Science
  • Education
  • Animals & Wildlife

Content Management System {πŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {πŸ’Έ}

We don’t know how the website earns money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {πŸ”}

google, scholar, evolution, mol, holmquist, evol, evolutionary, jukes, molecular, proteins, protein, article, theory, reh, method, press, biol, analysis, fitch, genetic, genes, parsimony, model, york, stochastic, privacy, cookies, journal, research, divergence, mutations, goodman, maximum, nature, nucleotide, science, eds, acid, sequences, content, data, information, publish, search, estimates, events, access, structure, dayhoff, phylogenetic,

Topics {βœ’οΈ}

month download article/chapter amino-acid sequnce investigations evolutionary biology move evolutionary estimates reh theory letters molecular evolution aims estimating evolutionary rates privacy choices/manage cookies quantitative evolutionary analysis humanΞ²-globin gene mammalian protein metabolism amino acid composition amino-acid composition beta hemoglobin mrnas maximum parsimony method nonuniform molecular divergence maximum entropy formalism molecular restoration studies protein structure full article pdf reh theory total mutations fixed european economic area determining codon variablity populous path algorithm molecular evolution conditions privacy policy evolutionary divergence specific tree topology additive similarity trees nucleic acid divergence check access instant access globin family genes accepting optional cookies comparing homologous sequences immunological distance data evolutionary implications evolutionary events rate-constancy hypothesis estimating superimposed mutations journal finder publish main content log evolutionary change increased variance sufficient homologous polypeptide chains protein sequences molecular divergence globin evolution selective structural constraints

Questions {❓}

  • Jaynes ET (1979) Where do we stand on maximum entropy?
  • Kimura M (1981) Was globin evolution very rapid in its early stages?
  • King JL (1980) Does the information density of amino acid composition increase?

Schema {πŸ—ΊοΈ}

WebPage:
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         headline:The current status of REH theory
         description:The recent evaluation by Fitch (1980) of REH theory for macromolecular divergence is a severely erroneous and distorted analysis of our work over the past decade. We reply to those distortions here. At present, there is no factual basis for believing Fitch's assessment that corrections which move evolutionary estimates of total mutations fixed closer to the true distance must do so at the expense of an increased variance sufficient to compromise the value of the improvement. By direct calculation the variance in the estimates of total mutations fixed given by REH theory is comparable to that of other models now in the literature for the case in which genetic events are equiprobable. A general argument is given that suggests that, as we consider more and more carefully the selective, functional, and structural constraints on the evolution of genes and proteins, this variance may be expected to decrease toward a lower bound.
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            Microbiology
            Plant Sciences
            Plant Genetics and Genomics
            Animal Genetics and Genomics
            Cell Biology
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            name:Journal of Molecular Evolution
            issn:
               1432-1432
               0022-2844
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         author:
               name:Richard Holmquist
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                        name:Space Sciences Laboratory, University of California at Berkely, Berkeley, USA
                        type:PostalAddress
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               type:Person
               name:Thomas H. Jukes
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      headline:The current status of REH theory
      description:The recent evaluation by Fitch (1980) of REH theory for macromolecular divergence is a severely erroneous and distorted analysis of our work over the past decade. We reply to those distortions here. At present, there is no factual basis for believing Fitch's assessment that corrections which move evolutionary estimates of total mutations fixed closer to the true distance must do so at the expense of an increased variance sufficient to compromise the value of the improvement. By direct calculation the variance in the estimates of total mutations fixed given by REH theory is comparable to that of other models now in the literature for the case in which genetic events are equiprobable. A general argument is given that suggests that, as we consider more and more carefully the selective, functional, and structural constraints on the evolution of genes and proteins, this variance may be expected to decrease toward a lower bound.
      datePublished:
      dateModified:
      pageStart:47
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      sameAs:https://doi.org/10.1007/BF01733211
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         Protein evolution
         Molecular evolution
         REH theory
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         Microbiology
         Plant Sciences
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         Animal Genetics and Genomics
         Cell Biology
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