We are analyzing https://link.springer.com/article/10.1007/bf01308606.

Title:
α-Smooth-muscle actin expression in normal and fibrotic human livers | Digestive Diseases and Sciences
Description:
To determine the significance of the expression of α-smooth-muscle actin in the fibrotic human liver, normal and diseased livers were stained with anti-α-smooth-muscle-actin antibody by an immunoperoxidase method. Vitamin A-containing lipocytes were also identified by the modified Kupffer
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Keywords {🔍}

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Topics {✒️}

anti-α-smooth-muscle-actin antibody α-smooth-muscle-actin-positive cells α-smooth-muscle actin adjacent α-smooth-muscle actin increased α-smooth-muscle actin expression month download article/chapter α-smooth-muscle actin α-smooth muscle actin hepatic stellate cells amino-terminal tryptic peptide smooth muscle cells smooth muscle differentiation article digestive diseases experimental liver cirrhosis fibrotic human liver experimental liver fibrosis intermediate filament proteins fibrotic human livers dimethylnitrosamine-induced cirrhosis privacy choices/manage cookies full article pdf toshihiko nouchi md hepatic fibrosis idiopathic pulmonary fibrosis nonparenchymal liver cells chronic alcoholic cirrhosis fibrotic rat liver diseased human livers normal human liver alcoholic liver injury alcoholic liver disease gold chloride reaction related subjects extracellular matrix components nonparenchymal cells cultivated fat-storing cells amino acid sequence contractile fibroblasts gold chloride method european economic area modified kupffer' blood vessel walls needle biopsy specimens diverse pathologic settings scleroderma fibroblastic cells article yamaoka conditions privacy policy enlarged portal areas reduced retinoid content accepting optional cookies

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         description:To determine the significance of the expression of α-smooth-muscle actin in the fibrotic human liver, normal and diseased livers were stained with anti-α-smooth-muscle-actin antibody by an immunoperoxidase method. Vitamin A-containing lipocytes were also identified by the modified Kupffer's gold chloride method. In the normal human liver, lipocytes as well as vascular smooth muscle cells expressed α-smooth-muscle actin. In alcoholic liver disease, there was an increase in the cells positive for α-smooth-muscle actin adjacent to the fibrotic areas, but the response of lipocytes to the gold chloride reaction diminished. In chronic hepatitis, the cells positive for α-smooth-muscle actin increased around the enlarged portal areas, and the response to the gold chloride reaction did not change appreciably. An increase in the cells positive for α-smooth-muscle actin was associated with the progression of hepatic fibrosis in the liver of patients with alcoholic liver disease and chronic hepatitis.
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      headline:α-Smooth-muscle actin expression in normal and fibrotic human livers
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         α-smooth-muscle actin
         lipocytes
         myofibroblasts
         liver fibrosis
         Kupffer's gold chloride staining
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         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
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