We are analyzing https://link.springer.com/article/10.1007/bf01296753.

Title:
High serum levels of secretory IgA in liver disease | Digestive Diseases and Sciences
Description:
Patients with liver disease frequently display unexplained elevations of serum secretory IgA (sIgA). The sIgA levels in various liver diseases were compared to various biochemical or clinical parameters. Patients with primary biliary cirrhosis, biliary tract obstruction, or acute hepatitis displayed highest sIgA levels. In chronic parenchymal liver disease sIgA levels correlated strongly with serum alkaline phosphatase (r=0.79), leucine aminopeptidase (r=0.83), and direct bilirubin levels (r=0.63), but not with prothrombin time, aminopyrine breath test, or presence of portacaval shunting. In acute hepatitis sIgA correlated best with serum glutamic oxaloacetic transaminase (r=0.69) but not with bilirubin; in four patients with fulminant hepatitis, sIgA fell rapidly together with all liver enzymes and prothrombin time; it rose quickly again in one patient when parenchymal regeneration occurred. These results suggest a hepatobiliary origin of the serum sIgA in liver disease. In acute hepatitis the persistence of hepatocytes seems necessary for maintaining high serum sIgA levels, suggesting a possible hepatocyte origin of the secretory component.
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Topics {✒️}

primary biliary cirrhosis month download article/chapter cliniques universitaires st-luc biliary tract obstruction site specific o-glycoforms acute hepatitis article digestive diseases parenchymal regeneration occurred privacy choices/manage cookies high serum levels full article pdf portal cirrhosis related subjects siga fell rapidly conventional liver tests secretory protein levels direct bilirubin levels serum leucine aminopeptidase aminopyrine breath test immunoglobulin-binding properties fulminant hepatitis human secretory component european economic area scope submit manuscript single-center experience automated nephelometric immunoassay chemically induced hepatomas specific alkaline phosphatase human secretory immunoglobulin levels predict biochemical conditions privacy policy check access instant access quantitative radio-immunoassay secretory piece linked secretory iga increase immunoelectron-microscopic localization serum secretory iga serum alkaline phosphatase accepting optional cookies siga levels brown wr quantitative function tests human intestinal mucosa journal finder publish cirrhosis liver disease liver diseases april 1982 volume 27 human secretory immunoglobulins

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         headline:High serum levels of secretory IgA in liver disease
         description:Patients with liver disease frequently display unexplained elevations of serum secretory IgA (sIgA). The sIgA levels in various liver diseases were compared to various biochemical or clinical parameters. Patients with primary biliary cirrhosis, biliary tract obstruction, or acute hepatitis displayed highest sIgA levels. In chronic parenchymal liver disease sIgA levels correlated strongly with serum alkaline phosphatase (r=0.79), leucine aminopeptidase (r=0.83), and direct bilirubin levels (r=0.63), but not with prothrombin time, aminopyrine breath test, or presence of portacaval shunting. In acute hepatitis sIgA correlated best with serum glutamic oxaloacetic transaminase (r=0.69) but not with bilirubin; in four patients with fulminant hepatitis, sIgA fell rapidly together with all liver enzymes and prothrombin time; it rose quickly again in one patient when parenchymal regeneration occurred. These results suggest a hepatobiliary origin of the serum sIgA in liver disease. In acute hepatitis the persistence of hepatocytes seems necessary for maintaining high serum sIgA levels, suggesting a possible hepatocyte origin of the secretory component.
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            Acute Hepatitis
            Glutamic Oxaloacetic Transaminase
            Aminopyrine
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            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
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      headline:High serum levels of secretory IgA in liver disease
      description:Patients with liver disease frequently display unexplained elevations of serum secretory IgA (sIgA). The sIgA levels in various liver diseases were compared to various biochemical or clinical parameters. Patients with primary biliary cirrhosis, biliary tract obstruction, or acute hepatitis displayed highest sIgA levels. In chronic parenchymal liver disease sIgA levels correlated strongly with serum alkaline phosphatase (r=0.79), leucine aminopeptidase (r=0.83), and direct bilirubin levels (r=0.63), but not with prothrombin time, aminopyrine breath test, or presence of portacaval shunting. In acute hepatitis sIgA correlated best with serum glutamic oxaloacetic transaminase (r=0.69) but not with bilirubin; in four patients with fulminant hepatitis, sIgA fell rapidly together with all liver enzymes and prothrombin time; it rose quickly again in one patient when parenchymal regeneration occurred. These results suggest a hepatobiliary origin of the serum sIgA in liver disease. In acute hepatitis the persistence of hepatocytes seems necessary for maintaining high serum sIgA levels, suggesting a possible hepatocyte origin of the secretory component.
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         Acute Hepatitis
         Glutamic Oxaloacetic Transaminase
         Aminopyrine
         Secretory Component
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         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
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